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  1. Lambert–Eaton myasthenic syndrome (LEMS) is a paraneoplastic syndrome and only 3% of small cell lung carcinoma (SCLC) patients have LEMS. Moreover, the recurrence of SCLC after a disease-free survival (DFS) of...

    Authors: Fumio Asano, Keisuke Watanabe, Masaharu Shinkai, Yoshitaka Tei, Kei Mishina, Mikiko Tanabe, Hiroshi Ishii, Masahiro Shinoda, Tadasuke Shimokawaji, Makoto Kudo and Takeshi Kaneko

    Citation: Chinese Journal of Cancer 2016 35:63

    Content type: Case report

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  2. Centrosomal protein 78 (CEP78) has been characterized as a component of the centrosome required for the regulation of centrosome-related events during the cell cycle, but its role in human cancers remains uncl...

    Authors: Meifang Zhang, Tingmei Duan, Li Wang, Jianjun Tang, Rongzhen Luo, Ruhua Zhang and Tiebang Kang

    Citation: Chinese Journal of Cancer 2016 35:62

    Content type: Original article

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  3. Validated preclinical studies have provided evidence that anti-vascular endothelial growth factor (VEGF) compounds enhance the activity of subsequent antitumor therapy, but the mechanism of this potentiation i...

    Authors: Ilaria Fuso Nerini, Marta Cesca, Francesca Bizzaro and Raffaella Giavazzi

    Citation: Chinese Journal of Cancer 2016 35:61

    Content type: Review

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  4. For patients with nasopharyngeal carcinoma (NPC) who undergo re-irradiation with intensity-modulated radiotherapy (IMRT), lethal nasopharyngeal necrosis (LNN) is a severe late adverse event. The purpose of thi...

    Authors: Ya-Hui Yu, Wei-Xiong Xia, Jun-Li Shi, Wen-Juan Ma, Yong Li, Yan-Fang Ye, Hu Liang, Liang-Ru Ke, Xing Lv, Jing Yang, Yan-Qun Xiang and Xiang Guo

    Citation: Chinese Journal of Cancer 2016 35:59

    Content type: Original article

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  5. It remains controversial whether palliative primary tumor resection (PPTR) can provide survival benefits to the patients with metastatic colorectal cancer (mCRC) who have unresectable metastases. The aim of th...

    Authors: Wen-Zhuo He, Yu-Ming Rong, Chang Jiang, Fang-Xin Liao, Chen-Xi Yin, Gui-Fang Guo, Hui-Juan Qiu, Bei Zhang and Liang-Ping Xia

    Citation: Chinese Journal of Cancer 2016 35:58

    Content type: Original article

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  6. The preoperative neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) are associated with poor prognosis of gastric cancer. We aimed to determine whether the combination of NLR and P...

    Authors: Xiaowei Sun, Xuechao Liu, Jianjun Liu, Shangxiang Chen, Dazhi Xu, Wei Li, Youqing Zhan, Yuanfang Li, Yingbo Chen and Zhiwei Zhou

    Citation: Chinese Journal of Cancer 2016 35:57

    Content type: Original article

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  7. For both men and women worldwide, colorectal cancer is among the leading causes of cancer-related death. This study aimed to assess the mortality trends of colorectal cancer in Serbia between 1991 and 2010, pr...

    Authors: Milena Ilic and Irena Ilic

    Citation: Chinese Journal of Cancer 2016 35:55

    Content type: Original article

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  8. Protein tyrosine kinase 6 (PTK6) is overexpressed in many epithelial tumors and predicts poor prognosis. However, PTK6 expression status and its role in cervical squamous cell cancer are unknown. This study ai...

    Authors: Xiao-Jing Wang, Ying Xiong, Ze-Biao Ma, Jian-Chuan Xia and Yan-Fang Li

    Citation: Chinese Journal of Cancer 2016 35:54

    Content type: Original article

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  9. Citation: Chinese Journal of Cancer 2016 35:52

    Content type: Erratum

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    The original article was published in Chinese Journal of Cancer 2016 35:32

  10. Androgen insensitivity syndrome (AIS), a disorder of sexual development in 46, XY individuals, is caused by loss-of-function mutations in the androgen receptor (AR) gene. A variety of tumors have been reported in...

    Authors: Vittoria Disciglio, Andrea Devecchi, Orazio Palumbo, Massimo Carella, Donata Penso, Massimo Milione, Giorgio Valle, Marco Alessandro Pierotti, Marco Vitellaro, Lucio Bertario, Silvana Canevari, Stefano Signoroni and Loris De Cecco

    Citation: Chinese Journal of Cancer 2016 35:51

    Content type: Case report

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  11. Radiotherapy is one of the main therapeutic approaches for non–small cell lung cancer (NSCLC). However, radioresistant cancer cells can eventually cause tumor relapse and even fatal metastasis. It is thought t...

    Authors: Yuan-Hu Yao, Yan Cui, Xiang-Nan Qiu, Long-Zhen Zhang, Wei Zhang, Hao Li and Jin-Ming Yu

    Citation: Chinese Journal of Cancer 2016 35:50

    Content type: Original article

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  12. The truncated chromosome 22 that results from the reciprocal translocation t(9;22)(q34;q11) is known as the Philadelphia chromosome (Ph) and is a hallmark of chronic myeloid leukemia (CML). In leukemia cells, ...

    Authors: Zhi-Jie Kang, Yu-Fei Liu, Ling-Zhi Xu, Zi-Jie Long, Dan Huang, Ya Yang, Bing Liu, Jiu-Xing Feng, Yu-Jia Pan, Jin-Song Yan and Quentin Liu

    Citation: Chinese Journal of Cancer 2016 35:48

    Content type: Review

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  13. Osteosarcoma is the most common bone malignancy in children and adolescents, and 20%–30% of the patients suffer from poor prognosis because of individual chemoresistance. The Hippo/yes-associated protein (YAP)...

    Authors: Dong-Yu Wang, Ya-Nan Wu, Jun-Qi Huang, Wei Wang, Meng Xu, Jin-Peng Jia, Gang Han, Bei-Bei Mao and Wen-Zhi Bi

    Citation: Chinese Journal of Cancer 2016 35:47

    Content type: Original article

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  14. Acute myeloid leukemia (AML) with t(8;21) is a heterogeneous disease. Identifying AML patients with t(8;21) who have a poor prognosis despite achieving remission is important for determining the best subsequen...

    Authors: Ya-Zhen Qin, Yu Wang, Hong-Hu Zhu, Robert Peter Gale, Mei-Jie Zhang, Qian Jiang, Hao Jiang, Lan-Ping Xu, Huan Chen, Xiao-Hui Zhang, Yan-Rong Liu, Yue-Yun Lai, Bin Jiang, Kai-Yan Liu and Xiao-Jun Huang

    Citation: Chinese Journal of Cancer 2016 35:46

    Content type: Original article

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  15. We recruited consecutive patients with stage III epithelial ovarian, tubal, and peritoneal cancers who had optimal residual tumor after primary cytoreductive surgery and who received intraperitoneal chemothera...

    Authors: Yen-Hou Chang, Chien-Hsing Lu, Ming-Shyen Yen, Wai-Hou Lee, Yi Chang, Wei-Pin Chang and Chi-Mu Chuang

    Citation: Chinese Journal of Cancer 2016 35:45

    Content type: Letter to the Editor

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  16. High-grade gliomas of the spinal cord represent a rare entity in children. Their biology, behavior, and controversial treatment options have been discussed in a few pediatric cases. These tumors are associated...

    Authors: Antonella Cacchione, Angela Mastronuzzi, Maria Giuseppina Cefalo, Giovanna Stefania Colafati, Francesca Diomedi-Camassei, Michele Rizzi, Alessandro De Benedictis and Andrea Carai

    Citation: Chinese Journal of Cancer 2016 35:44

    Content type: Case report

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  17. No consensus exists regarding the role of radiotherapy in the management of gynecologic cancer in nonagenarian patients. We retrospectively reviewed the outcomes of 19 consecutive nonagenarian patients with gy...

    Authors: Benoîte Méry, Sylvie Mengue Ndong, Jean-Baptiste Guy, Avi Assouline, Alexander T. Falk, Anaïs Valeille, Jane-Chloé Trone, Romain Rivoirard, Pierre Auberdiac, Alexis Vallard, Sophie Espenel, Guillaume Moriceau, Olivier Collard, Claire Bosacki, Jean-Philippe Jacquin, Guy de Laroche…

    Citation: Chinese Journal of Cancer 2016 35:43

    Content type: Letter to the Editor

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  18. The current World Health Organization (WHO) classification of nasopharyngeal carcinoma (NPC) conveys little prognostic information. This study aimed to propose an NPC histopathologic classification that can po...

    Authors: Hai-Yun Wang, Yih-Leong Chang, Ka-Fai To, Jacqueline S. G. Hwang, Hai-Qiang Mai, Yan-Fen Feng, Ellen T. Chang, Chen-Ping Wang, Michael Koon Ming Kam, Shie-Lee Cheah, Ming Lee, Li Gao, Hui-Zhong Zhang, Jie-Hua He, Hao Jiang, Pei-Qing Ma…

    Citation: Chinese Journal of Cancer 2016 35:41

    Content type: Original article

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  19. Bone metastases are common in patients with advanced cancer. Bisphosphonates (BPs) could prevent or delay the development of skeleton-related events (SREs). The present study aimed to identify the clinical fea...

    Authors: Yunpeng Yang, Yuxiang Ma, Jin Sheng, Yan Huang, Yuanyuan Zhao, Wenfeng Fang, Shaodong Hong, Ying Tian, Cong Xue and Li Zhang

    Citation: Chinese Journal of Cancer 2016 35:40

    Content type: Original article

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  20. Both hormonal therapy (HT) and maintenance capecitabine monotherapy (MCT) have been shown to extend time to progression (TTP) in patients with metastatic breast cancer (MBC) after failure of taxanes and anthra...

    Authors: Xue-Lian Chen, Feng Du, Ruo-Xi Hong, Jia-Yu Wang, Yang Luo, Qing Li, Ying Fan and Bing-He Xu

    Citation: Chinese Journal of Cancer 2016 35:39

    Content type: Original Article

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  21. Several studies suggested that hypertension is positively related to cancer incidence and mortality. In this study, we investigated the association between perioperative blood pressure (BP) and long-term survi...

    Authors: Hui-Chuan Yu, Yan-Xin Luo, Hui Peng, Xiao-Lin Wang, Zi-Huan Yang, Mei-Jin Huang, Liang Kang, Lei Wang and Jian-Ping Wang

    Citation: Chinese Journal of Cancer 2016 35:38

    Content type: Original Article

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  22. With the improved overall survival (OS) of nasopharyngeal carcinoma (NPC) patients, the importance of quality of life (QoL) is increasingly being recognized. For some radiosensitive NPC patients, whether low-d...

    Authors: Bing-Qing Xu, Zi-Wei Tu, Ya-Lan Tao, Zhi-Gang Liu, Xiao-Hui Li, Wei Yi, Chang-Bing Jiang and Yun-Fei Xia

    Citation: Chinese Journal of Cancer 2016 35:37

    Content type: Original Article

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  23. Cancer is a common cause of death worldwide. Despite significant advances in cancer treatments, the morbidity and mortality are still enormous. Tumor heterogeneity, especially intratumoral heterogeneity, is a ...

    Authors: Zhen Qin, Vladimir A. Ljubimov, Cuiqi Zhou, Yunguang Tong and Jimin Liang

    Citation: Chinese Journal of Cancer 2016 35:36

    Content type: Review

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  24. Although sentinel lymph node biopsy (SLNB) can accurately predict the status of axillary lymph node (ALN) metastasis, the high false-negative rate (FNR) of SLNB is still the main obstacle for the treatment of ...

    Authors: Chao Han, Ben Yang, Wen-Shu Zuo, Yan-Song Liu, Gang Zheng, Li Yang and Mei-Zhu Zheng

    Citation: Chinese Journal of Cancer 2016 35:35

    Content type: Original Article

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  25. Nasal-type extranodal natural killer/T-cell lymphoma (ENKTCL) originates primarily in the nasal cavity or extra-nasal sites within the upper aerodigestive tract. However, it is unclear whether the primary site...

    Authors: Shao-Qing Niu, Yong Yang, Yi-Yang Li, Ge Wen, Liang Wang, Zhi-Ming Li, Han-Yu Wang, Lu-Lu Zhang, Yun-Fei Xia and Yu-Jing Zhang

    Citation: Chinese Journal of Cancer 2016 35:34

    Content type: Original article

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  26. Carbon nanoparticles show significant lymphatic tropism and can be used to identify lymph nodes surrounding mid-low rectal tumors. In this study, we analyzed the effect of trans anal injection of a carbon nano...

    Authors: Xing-Mao Zhang, Jian-Wei Liang, Zheng Wang, Jian-tao Kou and Zhi-Xiang Zhou

    Citation: Chinese Journal of Cancer 2016 35:33

    Content type: Original article

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  27. The stromal interaction molecule (STIM)-calcium release-activated calcium channel protein (ORAI) and inositol 1,4,5-trisphosphate receptors (IP3Rs) play pivotal roles in the modulation of Ca2+-regulated pathways ...

    Authors: Jing Wen, Ying-Cheng Huang, Huan-Huan Xiu, Zhi-Ming Shan and Kang-Qing Xu

    Citation: Chinese Journal of Cancer 2016 35:32

    Content type: Review

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    The Erratum to this article has been published in Chinese Journal of Cancer 2016 35:52

  28. Epidermal growth factor receptor (EGFR) mutations, including a known exon 19 deletion (19 del) and exon 21 L858R point mutation (L858R mutation), are strong predictors of the response to EGFR tyrosine kinase inhi...

    Authors: Jiang-Yong Yu, Si-Fan Yu, Shu-Hang Wang, Hua Bai, Jun Zhao, Tong-Tong An, Jian-Chun Duan and Jie Wang

    Citation: Chinese Journal of Cancer 2016 35:30

    Content type: Original article

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  29. It remains unclear what the antiviral therapy affects disease-free survival (DFS) and overall survival (OS) of patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) at different tumor st...

    Authors: Jian-Lin Chen, Xiao-Jun Lin, Qian Zhou, Ming Shi, Sheng-Ping Li and Xiang-Ming Lao

    Citation: Chinese Journal of Cancer 2016 35:28

    Content type: Original Article

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  30. High quality studies have been challenging to undertake in patients with metastatic epidural spinal cord compression. Nonetheless, in the article “Survival and Clinical Outcomes in Surgically Treated Patients ...

    Authors: Anick Nater and Michael G. Fehlings

    Citation: Chinese Journal of Cancer 2016 35:27

    Content type: Research highlight

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  31. On October 31, 2015, the first Sino-Dutch symposium on oncology was organized in Guangzhou (China). The symposium revealed similarities between Chinese and Dutch efforts to improve the care of tumor patients a...

    Authors: Maikel P. Peppelenbosch

    Citation: Chinese Journal of Cancer 2016 35:26

    Content type: News and Views

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  32. Laparoscopic hepatectomy is increasingly being used to treat hepatocellular carcinoma (HCC). However, few studies have examined the treatment of recurrent HCC in patients who received a prior hepatectomy. The ...

    Authors: Jie Zhang, Zhong-Guo Zhou, Zhong-Xi Huang, Ke-Li Yang, Jian-Cong Chen, Jin-Bin Chen, Li Xu, Min-Shan Chen and Yao-Jun Zhang

    Citation: Chinese Journal of Cancer 2016 35:25

    Content type: Original article

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  33. Oral cancer is a common type of head and neck cancers. Knowing its epidemiologic characteristics is crucial to preventing, diagnosing, and treating this cancer. This study aimed to explore the epidemiologic ch...

    Authors: Ji Zhang, Fan Gao, An-Kui Yang, Wen-Kuan Chen, Shu-Wei Chen, Huan Li, Xing Zhang, Zhong-Yuan Yang, Xin-Lin Chen and Ming Song

    Citation: Chinese Journal of Cancer 2016 35:24

    Content type: Original Article

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  34. The limited clinical benefits from current antiangiogenic therapy for cancer patients have triggered some critical thoughts and insightful investigations aiming to further elucidate the relationship between ve...

    Authors: Francesco Pezzella, Kevin Gatter and Chao-Nan Qian

    Citation: Chinese Journal of Cancer 2016 35:22

    Content type: Editorial

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  35. In human patients, drugs that block tumor vessel growth are widely used to treat a variety of cancer types. Many rigorous phase 3 clinical trials have demonstrated significant survival benefits; however, the a...

    Authors: Yihai Cao

    Citation: Chinese Journal of Cancer 2016 35:21

    Content type: Review

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  36. Salvage treatment for locally recurrent nasopharyngeal carcinoma (NPC) is complicated and relatively limited. Radiotherapy, combined with effective concomitant chemotherapy, may improve clinical treatment out...

    Authors: Ying Guan, Shuai Liu, Han-Yu Wang, Ying Guo, Wei-Wei Xiao, Chun-Yan Chen, Chong Zhao, Tai-Xiang Lu and Fei Han

    Citation: Chinese Journal of Cancer 2016 35:20

    Content type: Original article

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  37. Directed capillary ingrowth has long been considered synonymous with tumor vascularization. However, the vasculature of primary tumors and metastases is not necessarily formed by endothelial cell sprouting; in...

    Authors: Edina Bugyik, Ferenc Renyi-Vamos, Vanessza Szabo, Katalin Dezso, Nora Ecker, Andras Rokusz, Peter Nagy, Balazs Dome and Sandor Paku

    Citation: Chinese Journal of Cancer 2016 35:19

    Content type: Review

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  38. Angiogenesis is not essential for tumours to develop and expand, as cancer can also grow in a non-angiogenic fashion, but why this type of growth occurs is unknown. Surprisingly, our data from mRNA transcripti...

    Authors: Omanma Adighibe, Russell D. Leek, Marta Fernandez-Mercado, Jiangting Hu, Cameron Snell, Kevin C. Gatter, Adrian L. Harris and Francesco Pezzella

    Citation: Chinese Journal of Cancer 2016 35:18

    Content type: Original Article

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  39. Viral infections contribute to approximately 12% of cancers worldwide, with the vast majority occurring in developing countries and areas. Two DNA viruses, Epstein-Barr virus (EBV) and human papillomavirus (HP...

    Authors: Ying Shi, Song-Ling Peng, Li-Fang Yang, Xue Chen, Yong-Guang Tao and Ya Cao

    Citation: Chinese Journal of Cancer 2016 35:16

    Content type: Review

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  40. Segmental ureterectomy is less invasive than radical nephroureterectomy and results in nephron preservation and satisfactory tumor control. This study was to determine the feasibility of segmental ureteroileal...

    Authors: Shu-Xiong Zeng, Xin Lu, Wei-Dong Xu, Zhen-Sheng Zhang, Hai-Hang Li, Ying-Hao Sun and Chuan-Liang Xu

    Citation: Chinese Journal of Cancer 2016 35:15

    Content type: Case Research

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  41. Endostatin (ES) is a well-established potent endogenous antiangiogenic factor. An ES variant, called zinc-binding protein-ES (ZBP-ES), is clinically available; however, its use is limited by rapid renal cleara...

    Authors: Shan Wang, Yan Fu and Yongzhang Luo

    Citation: Chinese Journal of Cancer 2016 35:14

    Content type: Original article

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