Muss HB, Case LD, Richards F 2nd, White DR, Cooper MR, Cruz JM, et al. Interrupted versus continuous chemotherapy in patients with metastatic breast cancer. The Piedmont Oncology association. N Engl J Med. 1991;325:1342–8.
Gregory RK, Powles TJ, Chang JC, Ashley S. A randomized trial of six versus twelve courses of chemotherapy in metastatic carcinoma of the breast. Eur J Cancer. 1997;33:2194–7.
Ejlertsen B, Pfeiffer P, Pedersen D, Mouridsen HT, Rose C, Overgaard M, et al. Decreased efficacy of cyclophosphamide, epirubicin and 5-fluorouracil in metastatic breast cancer when reducing treatment from 18 to 6 months. Eur J Cancer. 1993;29A:527–31.
Park YH, Jung KH, Im SA, Sohn JH, Ro J, Ahn JH, et al. Phase III, multicenter, randomized trial of maintenance chemotherapy versus observation in patients with metastatic breast cancer after achieving disease control with six cycles of gemcitabine plus paclitaxel as first-line chemotherapy: KCSG-BR07-02. J Clin Oncol. 2013;31:1732–40.
Nooij MA, de Haes JC, Beex LV, Wildiers J, Klijn J, Becquart D, et al. Continuing chemotherapy or not after the induction treatment in advanced breast cancer patients. Clinical outcomes and oncologists’ preferences. Eur J Cancer. 2003;39:614–21.
Stockler M, Wilcken N, Coates A. Chemotherapy for advanced breast cancer—how long should it continue? Breast Cancer Res Treat. 2003;81:49–52.
Gennari A, Stockler M, Puntoni M, Sormani M, Nanni O, Amadori D, et al. Duration of chemotherapy for metastatic breast cancer: a systematic review and meta-analysis of randomized clinical trials. J Clin Oncol. 2011;29:2144–9.
Alba E, Ruiz-Borrego M, Margeli M, Rodríguez-Lescure A, Sánchez-Rovira P, Ruiz A, et al. Maintenance treatment with pegylated liposomal doxorubicin versus observation following induction chemotherapy for metastatic breast cancer: GEICAM 2001-01 study. Breast Cancer Res Treat. 2010;122:169–76.
Ardizzoia A, Colombo I, Giordano M, Aglione S, Isa L, Scanni A, et al. Epirubicin–vinorelbine intravenous combination followed by oral vinorelbine as first-line treatment in metastatic breast cancer. Tumori. 2007;93:544–9.
Stockler MR, Harvey VJ, Francis PA, Byrne MJ, Ackland SP, Fitzharris B, et al. Capecitabine versus classical cyclophosphamide, methotrexate, and fluorouracil as first-line chemotherapy for advanced breast cancer. J Clin Oncol. 2011;29:4498–504.
Huang H, Jiang Z, Wang T, Zhang S, Bian L, Cao Y, et al. Single-agent capecitabine maintenance therapy after response to capecitabine-based combination chemotherapy in patients with metastatic breast cancer. Anticancer Drugs. 2012;23:718–23.
O’Shaughnessy JA, Kaufmann M, Siedentopf F. Capecitabine monotherapy: review of studies in first-line HER-2-negative metastatic breast cancer. Oncologist. 2012;17:476–84.
Henderson IC, Berry DA, Demetri GD, Cirrincione CT, Goldstein LJ, Martino S, et al. Improved outcomes from adding sequential Paclitaxel but not from escalating Doxorubicin dose in an adjuvant chemotherapy regimen for patients with node-positive primary breast cancer. J Clin Oncol. 2003;21:976–83.
Fumoleau P, Largillier R, Clippe C, Dieras V, Orfeuvre H, Lesimple T, et al. Multicentre, phase II study evaluating capecitabine monotherapy in patients with anthracycline and taxane-pretreated metastatic breast cancer. Eur J Cancer. 2004;40:536–42.
Reichardt P, von Minckwitz G, Thuss-Patience PC, Jonat W, Kölbl H, Jänicke F, et al. Multicenter phase II study of oral capecitabine (Xeloda®) in patients with metastatic breast cancer relapsing after treatment with a taxane-containing therapy. Ann Oncol. 2003;14:1227–33.
Donadio M, Ardine M, Berruti A, Beano A, Bottini A, Mistrangelo M, et al. Weekly cisplatin plus capecitabine in metastatic breast cancer patients heavily pretreated with both anthracycline and taxanes. Oncology. 2005;69:408–13.
Xu BH, Jiang ZF, Chua D, Shao ZM, Luo RC, Wang XJ, et al. Lapatinib plus capecitabine in treating HER2-positive advanced breast cancer: efficacy, safety, and biomarker results from Chinese patients. Chin J Cancer. 2011;30(5):327–35.
Bertelli G, Garrone O, Bertolotti L, Occelli M, Conforti S, Marzano N, et al. Maintenance hormone therapy with letrozole after first-line chemotherapy for advanced breast cancer. Oncology. 2005;68:364–70.
Lim S, Lee S, Han J, Park BW, Kim S, Park S, et al. Prolonged clinical benefit from the maintenance hormone therapy in patients with metastatic breast cancer. Breast. 2013;22:1205–9.
SchiavonG SmithIE. Status of adjuvant endocrine therapy for breast cancer. Breast Cancer Res. 2014;16(2):206–22.
Schiavon G, Smith IE. Endocrine therapy for advanced/metastatic breast cancer. Hematol Oncol Clin N Am. 2013;27:715–36.
Kloke O, Klaassen U, Oberhoff C, Hartwich G, Szanto J, Wolf E, et al. Maintenance treatment with medroxy progesterone acetate in patients with advanced breast cancer responding to chemotherapy: results of a randomized trial. Essen Breast Cancer Study Group. Breast Cancer Res Treat. 1999;55:51–9.
Si W, Zhu YY, Li Y, Gao P, Han C, You JH, et al. Capecitabine maintenance therapy in patients with recurrent or metastatic breast cancer. Braz J Med Biol Res. 2013;46:1074–81.
Roché H, Vahdat LT. Treatment of metastatic breast cancer: second line and beyond. Ann Oncol. 2011;22:1000–10.
Fedele P, Orlando L, Schiavone P, Calvani N, Caliolo C, Quaranta A, et al. Recent advances in the treatment of hormone receptor positive HER2 negative metastatic breast cancer. Crit Rev Oncol Hematol. 2015;94:291–301.