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  1. Content type: Original article

    The optimal strategy for adjuvant therapy after curative resection for hepatocellular carcinoma (HCC) patients with solitary tumor and microvascular invasion (MVI) is controversial. This trial evaluated the ef...

    Authors: Wei Wei, Pei-En Jian, Shao-Hua Li, Zhi-Xing Guo, Yong-Fa Zhang, Yi-Hong Ling, Xiao-Jun Lin, Li Xu, Ming Shi, Lie Zheng, Min-Shan Chen and Rong-Ping Guo

    Citation: Cancer Communications 2018 38:61

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  2. Content type: Original article

    Patient-derived organoids and xenografts (PDXs) have emerged as powerful models in functional diagnostics with high predictive power for anticancer drug response. However, limitations such as engraftment failu...

    Authors: Feifei Zhang, Wenjie Wang, Yuan Long, Hui Liu, Jijun Cheng, Lin Guo, Rongyu Li, Chao Meng, Shan Yu, Qingchuan Zhao, Shun Lu, Lili Wang, Haitao Wang and Danyi Wen

    Citation: Cancer Communications 2018 38:60

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  3. Content type: Original article

    Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperplasia, the positive rate for malignancy identification during biopsy is low, thus leading to delayed or missed diag...

    Authors: Chaofeng Li, Bingzhong Jing, Liangru Ke, Bin Li, Weixiong Xia, Caisheng He, Chaonan Qian, Chong Zhao, Haiqiang Mai, Mingyuan Chen, Kajia Cao, Haoyuan Mo, Ling Guo, Qiuyan Chen, Linquan Tang, Wenze Qiu…

    Citation: Cancer Communications 2018 38:59

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  4. Content type: Original article

    Breast cancer stem cells (BCSCs) are considered responsible for cancer relapse and drug resistance. Understanding the identity of BCSCs may open new avenues in breast cancer therapy. Although several discoveri...

    Authors: Mengying Tong, Ziqian Deng, Mengying Yang, Chang Xu, Xiaolong Zhang, Qingzheng Zhang, Yuwei Liao, Xiaodi Deng, Dekang Lv, Xuehong Zhang, Yu Zhang, Peiying Li, Luyao Song, Bicheng Wang, Aisha Al-Dherasi, Zhiguang Li…

    Citation: Cancer Communications 2018 38:56

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  5. Content type: Original article

    The tumor–node–metastasis (TNM) staging system does not perform well for guiding individualized induction or adjuvant chemotherapy for patients with locoregionally advanced nasopharyngeal carcinoma (NPC). We a...

    Authors: Pu-Yun OuYang, Kai-Yun You, Lu-Ning Zhang, Yao Xiao, Xiao-Min Zhang and Fang-Yun Xie

    Citation: Cancer Communications 2018 38:55

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  6. Content type: Original article

    Treatment guidelines for a variety of cancers have been increasingly used in clinical practice, and have resulted in major improvement in patient outcomes. However, recommended regimens (even first-line treatm...

    Authors: Peng Zhao, Hui Chen, Danyi Wen, Shuo Mou, Feifei Zhang and Shusen Zheng

    Citation: Cancer Communications 2018 38:54

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  7. Content type: Original article

    We previously found that overexpression of the gene known as amplified in breast cancer 1 (AIB1) was associated with lymph node metastasis and poor prognosis in patients with lung adenocarcinoma. However, the rol...

    Authors: Liru He, Haixia Deng, Shiliang Liu, Jiewei Chen, Binkui Li, Chenyuan Wang, Xin Wang, Yiguo Jiang, Ningfang Ma, Mengzhong Liu and Dan Xie

    Citation: Cancer Communications 2018 38:53

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  8. Content type: Original article

    The antitumour efficacy of tyrosine kinase inhibitors (TKIs) in lung cancer patients with compound epidermal growth factor receptor (EGFR) mutations has not been resolved. Our study summarizes a single institutio...

    Authors: Xiangyang Yu, Xuewen Zhang, Zichen Zhang, Yongbin Lin, Yingsheng Wen, Yongqiang Chen, Weidong Wang and Lanjun Zhang

    Citation: Cancer Communications 2018 38:51

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  9. Content type: Original article

    In previous studies, we have shown that the combination of metformin and gefitinib inhibits the growth of bladder cancer cells. Here we examined whether the metformin analogue phenformin, either used alone or ...

    Authors: Yanjun Huang, Sichun Zhou, Caimei He, Jun Deng, Ting Tao, Qiongli Su, Kwame Oteng Darko, Mei Peng and Xiaoping Yang

    Citation: Cancer Communications 2018 38:50

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  10. Content type: Original article

    Induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) share many common features, including similar morphology, gene expression and in vitro differentiation profiles. However, genomic stabilit...

    Authors: Minjie Zhang, Liu Wang, Ke An, Jun Cai, Guochao Li, Caiyun Yang, Huixian Liu, Fengxia Du, Xiao Han, Zilong Zhang, Zitong Zhao, Duanqing Pei, Yuan Long, Xin Xie, Qi Zhou and Yingli Sun

    Citation: Cancer Communications 2018 38:49

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  11. Content type: Original article

    Gallbladder carcinoma is highly aggressive and resistant to chemotherapy, with no consistent strategy to guide first line chemotherapy. However, patient-derived xenograft (PDX) model has been increasingly used...

    Authors: Ming Zhan, Rui-meng Yang, Hui Wang, Min He, Wei Chen, Sun-wang Xu, Lin-hua Yang, Qiang Liu, Man-mei Long and Jian Wang

    Citation: Cancer Communications 2018 38:48

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  12. Content type: Original article

    Gastric cancer (GC) is one of the most common malignancies worldwide, particularly in China. DNA damage-inducible transcript 4 (DDIT4) is a mammalian target of rapamycin inhibitor and is induced by various cel...

    Authors: Feng Du, Lina Sun, Yi Chu, Tingyu Li, Chao Lei, Xin Wang, Mingzuo Jiang, Yali Min, Yuanyuan Lu, Xiaodi Zhao, Yongzhan Nie and Daiming Fan

    Citation: Cancer Communications 2018 38:45

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  13. Content type: Original article

    It remains unclear if the vascular and connective tissue structures of primary and metastatic tumors are intrinsically determined or whether these characteristics are defined by the host tissue. Therefore we e...

    Authors: Edina Bugyik, Vanessza Szabó, Katalin Dezső, András Rókusz, Armanda Szücs, Péter Nagy, József Tóvári, Viktória László, Balázs Döme and Sándor Paku

    Citation: Cancer Communications 2018 38:46

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  14. Content type: Original article

    The relationship between cancer and life expectancy is well established in both developed and developing countries. China is a vast country with significant geographical differences in population structure and...

    Authors: Xiuying Gu, Rongshou Zheng, Changfa Xia, Hongmei Zeng, Siwei Zhang, Xiaonong Zou, Zhixun Yang, He Li and Wanqing Chen

    Citation: Cancer Communications 2018 38:44

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  15. Content type: Original article

    Azithromycin is a member of macrolide antibiotics, and has been reported to inhibit the proliferation of cancer cells. However, the underlying mechanisms are not been fully elucidated. Tumor necrosis factor-re...

    Authors: Xinran Qiao, Xiaofei Wang, Yue Shang, Yi Li and Shu-zhen Chen

    Citation: Cancer Communications 2018 38:43

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  16. Content type: Original Article

    Asians are diagnosed with breast cancer at a younger age than Caucasians are. We studied the effect of age on locoregional recurrence and the survival of Asian breast cancer patients treated with breast-conser...

    Authors: Fuh Yong Wong, Wei Ying Tham, Wen Long Nei, Cindy Lim and Hui Miao

    Citation: Cancer Communications 2018 38:39

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  17. Content type: Case report

    Hepatocellular carcinoma (HCC) is one of the most frequent causes of cancer-related death. Sorafenib, a multitarget angiogenesis inhibitor, is an approved frontline treatment for advanced HCC in Western countr...

    Authors: Giovanni Brandi, Michela Venturi, Stefania De Lorenzo, Francesca Garuti, Giorgio Frega, Andrea Palloni, Ingrid Garajovà, Francesca Abbati, Gioconda Saccoccio, Rita Golfieri, Maria Abbondanza Pantaleo and Maria Aurelia Barbera

    Citation: Cancer Communications 2018 38:41

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  18. Content type: Review

    Boron neutron capture therapy (BNCT) is a binary radiotherapeutic modality based on the nuclear capture and fission reactions that occur when the stable isotope, boron-10, is irradiated with neutrons to produc...

    Authors: Rolf F. Barth, Peng Mi and Weilian Yang

    Citation: Cancer Communications 2018 38:35

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  19. Content type: Original article

    Although the most commonly recommended treatment for melanoma and extramammary Paget’s disease (EMPD) of the genital region is wide surgical excision of the lesion, the procedure is highly invasive and can lea...

    Authors: Junichi Hiratsuka, Nobuhiko Kamitani, Ryo Tanaka, Eisaku Yoden, Ryuji Tokiya, Minoru Suzuki, Rolf F. Barth and Koji Ono

    Citation: Cancer Communications 2018 38:38

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  20. Content type: Review

    Head and neck (HN) cancer is an endemic disease in Taiwan, China. Locally recurrent HN cancer after full-dose irradiation poses a therapeutic challenge, and boron neutron capture therapy (BNCT) may be a soluti...

    Authors: Ling-Wei Wang, Yen-Wan Hsueh Liu, Fong-In Chou and Shiang-Huei Jiang

    Citation: Cancer Communications 2018 38:37

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  21. Content type: News and Views

    Following publication of the results of the National Lung Screening Trial in the United States, a randomized controlled trial in Italy (ITALUNG) and two simulation studies in China reported similar findings in...

    Authors: Zixing Wang, Yuyan Wang, Yao Huang, Fang Xue, Wei Han, Yaoda Hu, Lei Wang, Wei Song and Jingmei Jiang

    Citation: Cancer Communications 2018 38:34

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  22. Content type: Original article

    Cisplatin-based chemotherapy with concurrent radiotherapy is a standard treatment for advanced esophageal squamous cell carcinoma (ESCC). NS1-binding protein (NS1-BP), a member of the BTB-kelch protein family,...

    Authors: Yuwen Wang, Jingjing Cheng, Dan Xie, Xiaofeng Ding, Hailing Hou, Xi Chen, Puchun Er, Furong Zhang, Lujun Zhao, Zhiyong Yuan, Qingsong Pang, Ping Wang and Dong Qian

    Citation: Cancer Communications 2018 38:33

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  23. Content type: Original article

    Combination therapy with oxaliplatin, irinotecan, fluorouracil, and leucovorin (FOLFIRINOX) chemotherapy drastically improves survival of advanced pancreatic cancer patients. However, the efficacy of FOLFIRINO...

    Authors: Jung Hoon Kim, Sang-Cheol Lee, Sung Yong Oh, Seo-Young Song, Namsu Lee, Eun Mi Nam, Soonil Lee, In Gyu Hwang, Hyo Rak Lee, Kyu Taek Lee, Sang-Byung Bae, Han Jo Kim, Joung Soon Jang, Do Hyoung Lim, Hyun Woo Lee, Seok Yun Kang…

    Citation: Cancer Communications 2018 38:32

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  24. Content type: Original article

    Patients with relapsed/refractory B-cell lymphomas have limited treatment options. GERSHWIN is an open-label, single-arm, phase Ib study of obinutuzumab monotherapy in Chinese patients with histologically docu...

    Authors: Yan Qin, Yuqin Song, Zhixiang Shen, Xin Du, Wei Ji, Wanling Hsu, Jun Zhu and Yuankai Shi

    Citation: Cancer Communications 2018 38:31

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  25. Content type: Original article

    Although colorectal oligometastases to the liver can potentially be cured with aggressive local ablation, the efficacy of adjuvant chemotherapy (ACT) for such metastasis remains unclear. The present study expl...

    Authors: Zhizhong Pan, Jianhong Peng, Junzhong Lin, Gong Chen, Xiaojun Wu, Zhenhai Lu, Yuxiang Deng, Yujie Zhao, Qiaoqi Sui and Desen Wan

    Citation: Cancer Communications 2018 38:29

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  26. Content type: Case report

    Spontaneous regression has been reported in some indolent forms of lymphoma. Mantle cell lymphoma (MCL) is an aggressive lymphoid neoplasm and has a poor prognosis. However, approximately 30% of MCL patients c...

    Authors: Haige Ye, Aakash Desai, Tiejun Gong, Dongfeng Zeng, Krystle Nomie, Wendy Chen, Wei Wang, Jorge Romaguera and Michael L. Wang

    Citation: Cancer Communications 2018 38:30

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  27. Content type: Original article

    Plasma circulating tumor DNA (ctDNA) is an ideal approach to detecting the epidermal growth factor receptor (EGFR) T790M mutation, which is a major mechanism of resistance to first-generation EGFR-tyrosine kinase...

    Authors: Shirong Zhang, Lucheng Zhu, Bing Xia, Enguo Chen, Qiong Zhao, Xiaochen Zhang, Xueqin Chen, Xufeng Chen and Shenglin Ma

    Citation: Cancer Communications 2018 38:28

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  28. Content type: Original article

    Neoadjuvant chemoradiotherapy followed by surgery is recommended as the standard of care for locally advanced rectal cancer, reducing local recurrence but not distant metastasis. Intensified systemic therapy i...

    Authors: Xin Yu, Qiao-xuan Wang, Wei-wei Xiao, Hui Chang, Zhi-fan Zeng, Zhen-hai Lu, Xiao-jun Wu, Gong Chen, Zhi-zhong Pan, De-sen Wan, Pei-rong Ding and Yuan-hong Gao

    Citation: Cancer Communications 2018 38:24

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  29. Content type: Review

    Dysregulation of metabolism allows tumor cells to generate needed building blocks as well as to modulate epigenetic marks to support cancer initiation and progression. Cancer-induced metabolic changes alter th...

    Authors: Yi-Ping Wang and Qun-Ying Lei

    Citation: Cancer Communications 2018 38:25

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  30. Content type: Original article

    Average postoperative follow-up intervals vary in patients undergoing hepatocellular carcinoma (HCC) resection because of limited evidence regarding the optimal interval. We aimed to compare the associations o...

    Authors: Wei He, Yun Zheng, Ruhai Zou, Jingxian Shen, Junping Yang, Jiliang Qiu, Qiang Tao, Wenwu Liu, Zhiwen Yang, Yuanping Zhang, Binkui Li and Yunfei Yuan

    Citation: Cancer Communications 2018 38:26

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  31. Content type: Original article

    Few studies have shown nomograms that may predict disease-specific survival (DSS) probability after curative D2 gastrectomy for advanced gastric cancer (AGC), particularly among Chinese patients. This study so...

    Authors: Wei Wang, Zhe Sun, Jing-Yu Deng, Xiao-Long Qi, Xing-Yu Feng, Cheng Fang, Xing-Hua Ma, Zhen-Ning Wang, Han Liang, Hui-Mian Xu and Zhi-Wei Zhou

    Citation: Cancer Communications 2018 38:23

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  32. Content type: Original article

    5-Fluorouracil (5-FU) and capecitabine-associated cardiotoxicity ranging from asymptomatic electrocardiography (ECG) abnormalities to severe myocardial infarction has been reported in a number of studies, but ...

    Authors: Jianjun Peng, Chao Dong, Chang Wang, Weihua Li, Hao Yu, Min Zhang, Qun Zhao, Bo Zhu, Jun Zhang, Wenliang Li, Fenghua Wang, Qiong Wu, Wenhao Zhou, Ying Yuan, Meng Qiu and Gong Chen

    Citation: Cancer Communications 2018 38:22

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  33. Content type: Original article

    Available data in the literature comparing different induction chemotherapy (IC) regimens on locoregionally advanced nasopharyngeal carcinoma (NPC) are scarce. The purpose of the present study was to evaluate ...

    Authors: Guo-Ying Liu, Xing Lv, Yi-Shan Wu, Min-Jie Mao, Yan-Fang Ye, Ya-Hui Yu, Hu Liang, Jing Yang, Liang-Ru Ke, Wen-Ze Qiu, Xin-Jun Huang, Wang-Zhong Li, Xiang Guo, Yan-Qun Xiang and Wei-Xiong Xia

    Citation: Cancer Communications 2018 38:21

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  34. Content type: Original article

    Non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations or anaplastic lymphoma kinase (ALK) fusions show dramatic responses to specific tyrosine kinase inhibitors (TKIs)...

    Authors: Yunhua Xu, Feifei Zhang, Xiaoqing Pan, Guan Wang, Lei Zhu, Jie Zhang, Danyi Wen and Shun Lu

    Citation: Cancer Communications 2018 38:19

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  35. Content type: Original article

    Enlarged retropharyngeal lymph nodes (RLNs) are very common in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy. The most suitable treatment option for enlarged RLNs depends on the patholog...

    Authors: Long-Jun He, Chuanbo Xie, Yin Li, Lin-Na Luo, Ke Pan, Xiao-Yan Gao, Li-Zhi Liu, Jian-Ming Gao, Guang-Yu Luo, Hong-Bo Shan, Ming-Yuan Chen, Chong Zhao, Wei-Jun Fan, Ping Yang, Guo-Liang Xu and Jian-Jun Li

    Citation: Cancer Communications 2018 38:20

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  36. Content type: Original article

    Our previous study demonstrated that aldolase A (ALDOA) is overexpressed in clinical human lung squamous cell carcinoma and that ALDOA promotes epithelial–mesenchymal transition and tumorigenesis. The present ...

    Authors: Hailu Fu, Huijun Gao, Xiaoyu Qi, Lei Zhao, Donghua Wu, Yuxin Bai, Huimin Li, Xuan Liu, Jun Hu and Shujuan Shao

    Citation: Cancer Communications 2018 38:18

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  37. Content type: Review

    Precision medicine has shed new light on the treatment of heterogeneous cancer patients. However, intratumor heterogeneity strongly constrains the clinical benefit of precision medicine. Thus, rethinking thera...

    Authors: Mengying Tong, Ziqian Deng, Xiaolong Zhang, Bin He, Mengying Yang, Wei Cheng and Quentin Liu

    Citation: Cancer Communications 2018 38:17

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  38. Content type: Original article

    Tumor hypoxia is considered an important factor in metastasis and disease relapse. Evofosfamide is a hypoxia-activated prodrug that selectively targets the hypoxic regions of solid tumors. As hypoxia-inducible...

    Authors: Yan Huang, Ying Tian, Yuanyuan Zhao, Cong Xue, Jianhua Zhan, Lin Liu, Xiaobo He and Li Zhang

    Citation: Cancer Communications 2018 38:15

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  39. Content type: Original article

    Pancreatic duct adenocarcinoma (PDAC) remains a major health problem because conventional cancer treatments are relatively ineffective against it. Microarray studies have linked many genes to pancreatic cancer...

    Authors: Jun Li, Wenle Tan, Linna Peng, Jialiang Zhang, Xudong Huang, Qionghua Cui, Jian Zheng, Wen Tan, Chen Wu and Dongxin Lin

    Citation: Cancer Communications 2018 38:13

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  40. Content type: Original article

    The association between type 2 diabetes mellitus (T2DM) and the risk of esophageal cancer remains unclear. The present study aimed to evaluate the impact of T2DM on short-term outcomes and long-term survival i...

    Authors: Wang Yao, Yuqi Meng, Mingjian Lu, Wenzhe Fan, Jinhua Huang, Jiaping Li and Zhihua Zhu

    Citation: Cancer Communications 2018 38:14

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  41. Content type: Review

    Cancer cells often upregulate nutrient transporters to fulfill their increased biosynthetic and bioenergetic needs, and to maintain redox homeostasis. One nutrient transporter frequently overexpressed in human...

    Authors: Pranavi Koppula, Yilei Zhang, Li Zhuang and Boyi Gan

    Citation: Cancer Communications 2018 38:12

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