- Original article
- Open Access
Proposal and validation of a modified staging system to improve the prognosis predictive performance of the 8th AJCC/UICC pTNM staging system for gastric adenocarcinoma: a multicenter study with external validation
- Cheng Fang†1,
- Wei Wang†1,
- Jing-Yu Deng†2,
- Zhe Sun3,
- Sharvesh Raj Seeruttun1,
- Zhen-Ning Wang3,
- Hui-Mian Xu3Email author,
- Han Liang2Email author and
- Zhi-Wei Zhou1Email authorView ORCID ID profile
© The Author(s) 2018
- Received: 16 March 2018
- Accepted: 6 November 2018
- Published: 19 November 2018
The 8th edition of the American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) pathological tumor-node-metastasis (pTNM) staging system may have increased accuracy in predicting prognosis of gastric cancer due to its important modifications from previous editions. However, the homogeneity in prognosis within each subgroup classified according to the 8th edition may still exist. This study aimed to compare and analyze the prognosis prediction abilities of the 8th and 7th editions of AJCC/UICC pTNM staging system for gastric cancer and propose a modified pTNM staging system with external validation.
In total, clinical data of 7911 patients from three high-capacity institutions in China and 10,208 cases from the Surveillance, Epidemiology, and End Results (SEER) Program Registry were analyzed. The homogeneity, discriminatory ability, and monotonicity of the gradient assessments of the 8th and 7th editions of AJCC/UICC pTNM staging system were compared using log-rank χ2, linear-trend χ2, likelihood-ratio χ2 statistics and Akaike information criterion (AIC) calculations, on which a modified pTNM classification with external validation using the SEER database was proposed.
Considerable stage migration, mainly for stage III, between the 8th and 7th editions was observed in both cohorts. The survival rates of subgroups of patients within stage IIIA, IIIB, or IIIC classified according to both editions were significantly different, demonstrating poor homogeneity for patient stratification. A modified pTNM staging system using data from the Chinese cohort was then formulated and demonstrated an improved homogeneity in these abovementioned subgroups. This staging system was further validated using data from the SEER cohort, and similar promising results were obtained. Compared with the 8th and 7th editions, the modified pTNM staging system displayed the highest log-rank χ2, linear-trend χ2, likelihood-ratio χ2, and lowest AIC values, indicating its superior discriminatory ability, monotonicity, homogeneity and prognosis prediction ability in both populations.
The 8th edition of AJCC/UICC pTNM staging system is superior to the 7th edition, but still results in homogeneity in prognosis prediction. Our modified pTNM staging system demonstrated the optimal stratification and prognosis prediction ability in two large cohorts of different gastric cancer populations.
- Pathological TNM staging system
- Gastric cancer
- Akaike information criterion (AIC)
- Prognosis prediction
Gastric cancer (GC) remains both the second most prevalent cancer  and the most frequent cause of cancer-related death in China . Nearly half of the global total new GC diagnoses each year occur in China [3, 4]. Although current practice includes chemotherapy, irradiation, and/or targeted therapy in the treatment protocol, surgical resection remains the only means for cure . Regarding the prognostic markers for patients undergoing surgical treatment, the American Joint Committee on Cancer (AJCC)/International Union against Cancer (UICC) pathological tumor-node-metastasis (pTNM) staging system is currently used as the most important and basic tool for patient stratification. The AJCC/UICC has published the 8th edition of pTNM staging system for GC and has introduced some changes on the basis of the 7th edition [6, 7]. Among those changes, the most important one is the subdivision of the category N3ab into N3a and N3b, which affects consequent staging, especially for stage III. Thus, the prediction of survival probability of stage III patients are believed to be considerably affected, and this latest edition may have implications on treatment. To date, although the prognosis prediction ability of the 8th AJCC/UICC pTNM staging system for GC has already been addressed, its accuracy remains unclear.
In this retrospective study, we compared the prognosis prediction abilities of the 8th and 7th editions of AJCC/UICC pTNM staging system using a large Chinese multicenter database of GC as a training cohort. We then proposed a modified pTNM staging system for better prognosis prediction of advanced GC and performed external validation in a large cohort of Western GC patients.
Between January 1, 2000 and December 31, 2012, a consecutive cohort of GC patients who underwent radical gastrectomy at the Department of Gastric Surgery at the Sun Yat-sen University Cancer Center (SYSUCC), Department of Gastric Cancer Surgery at Tianjin Medical University Cancer Institute & Hospital (TJMU), and Department of Surgical Oncology at the First Hospital of China Medical University (CMU) were selected. The eligibility criteria were as follows: (1) pathologically confirmed primary gastric adenocarcinoma; (2) no synchronous malignancy; (3) no distant metastasis; (4) no preoperative chemotherapy; (5) patients having undergone gastrectomy plus lymphadenectomy (limited or extended) according to the Japanese Gastric Cancer Treatment Guidelines 2014 (version 3) ; (6) R0 resection (i.e., no residual macroscopic or microscopic tumor); (7) postoperative survival of at least 3 months; and (8) patients with no missing data regarding the analyzed clinicopathological characteristics.
From 18 registries of the Surveillance, Epidemiology, and End Results Program (SEER), a retrospective review of clinical records of all GC patients who underwent gastrectomy between January 1998 and December 2012 was performed. The patients were excluded if they had incomplete/missing information regarding their age, tumor size, tumor location, Lauren type, depth of invasion, lymph node status, non-radical resection, and/or status of distant metastasis. This study protocol was approved by the institutional review boards of SYSU, TJMU, and CMU.
A strict disease-monitoring program with outpatient records, telephonic interviews, and electronic messages was conducted and included clinical and laboratory examinations every 3 months for the first 2 years, every 6 months from the 3rd to the 5th years, and annually thereafter until at least 5 years after the operation or until the patient died, whichever came first. The last date of follow-up was December 31, 2016. The endpoint of this study was overall survival (OS), which was defined as the date from surgery until the date of death or the last date of follow up. Patients who were still alive after the completion of follow-up were all censored.
All patients were restaged according to the 8th and 7th AJCC/UICC GC pTNM staging systems. Survival curves were plotted using the Kaplan–Meier method, and the log-rank test was used to determine the relationships between the investigated clinicopathological factors and OS. Factors deemed having potential significance (P < 0.05) on univariate analysis were included in multivariate analyses. Multivariate analysis of OS was performed using the Cox proportional hazards model with the forward logistic regression (LR) stepwise procedure for variable selection.
The prognosis prediction performance of the 8th and 7th AJCC/UICC GC staging systems was investigated in terms of discriminatory ability (differences in the survival among patients in different stages), monotonicity (patients at earlier stages with longer survival than those in later stages), homogeneity (small differences in the survival among patients within the same stage) . The log-rank χ2 test, linear-trend χ2 test, likelihood-ratio χ2 test, and Akaike information criterion (AIC) within the Cox regression model were used to compare the stratification and prognosis prediction performance between the two editions of staging systems. The discriminatory ability and monotonicity of gradient assessments were measured using the log-rank χ2 test and the linear-trend χ2 test. Homogeneity was measured using the likelihood-ratio χ2 test, and AIC was used to measure the prognostic stratifications. Higher log-rank χ2 and linear-trend χ2 scores indicated better discriminatory ability and monotonicity, higher likelihood-ratio χ2 scores indicated greater homogeneity, and smaller AIC values represented better prognostic stratification. Hazard ratios (HR) and 95% confidence intervals (95% CI) were also generated. All calculations were performed using SPSS 20.0 software (SPSS Inc., Chicago, IL, USA), and a P value < 0.05 was considered statistically significant.
Patient clinicopathological features, univariate and multivariate analyses
Clinicopathologic variables and univariate analysis of the Chinese training cohort and SEER external validation cohort of gastric cancer patients
Training cohort (n = 7911)
External validation cohort (n = 10,208)
No. of patients [cases (%)]
5-year OS rate (%)
No. of patients [cases (%)]
5-year OS rate (%)
Tumor size (cm)
pTNM stage (7th ed.)
pTNM stage (8th ed.)
pTNM stage (modified)
Multivariate survival analyses of the training and external validation cohorts of gastric cancer patients
The 7th AJCC/UICC staging system
The 8th AJCC/UICC staging system
The modified staging system
External validation cohort
Discriminatory ability and monotonicity of the 7th and 8th AJCC/UICC staging systems
Homogeneity of the 7th and 8th AJCC/UICC staging systems
In the external validation cohort, the 7th AJCC/UICC staging system demonstrated good homogeneity in stage IIIA (P = 0.397; Fig. 4j), but not in stages IIIB and IIIC (P = 0.034 and P = 0.005; Fig. 4k, l); the 8th AJCC/UICC staging system demonstrated good homogeneity in stages IIIA and IIIC (P = 0.085 and 0.060; Fig. 4m, o), but not in stage IIIB (P = 0.002; Fig. 4n).
Proposal of a modified pTNM staging system
Prognosis prediction performances of the 7th and 8th AJCC/UICC staging systems against the modified pTNM staging system
Comparison of prognosis prediction performances of the 7th and 8th AJCC/UICC staging systems with the modified pTNM staging system
pTNM staging system
External validation cohort
In the present study, both the 7th and 8th AJCC/UICC staging systems demonstrated poor homogeneity in the training and external validation cohorts, particularly for stages IIIA, IIIB, and IIIC, an observation that was not mentioned by the International Gastric Cancer Association (IGCA). Thus, a modified pTNM staging system was proposed. For convenience in the clinical application of the proposed modified pTNM staging system, the classifications of “T” and “N” categories were not altered, and, based on our statistics, we focused on a more homogenized re-classification approach to improve the subgroup classification. The Kaplan–Meier OS curves demonstrated similarity among the subgroups of patients within stage IIIA, IIIB, or IIIC classified according to the modified pTNM staging system and revealed optimal homogeneity. Furthermore, compared with the 7th and 8th AJCC/UICC staging systems, the modified pTNM staging system also displayed the best homogeneity, discriminatory ability, and monotonicity of gradients both in the training and external validation cohorts.
The TNM staging system is the common “language of cancer” [10, 11], enabling comparisons between different populations irrespective of country and ethnicity. With the improvement of surgical techniques, the number of retrieved LNs is increased dramatically, and the definition of the category N3ab as the presence of more than 6 metastatic LNs is too broad. In the 8th AJCC/UICC pTNM staging system for GC, the category N3ab is subdivided into N3a and N3b to improve the accuracy of staging and prognosis prediction. Our results have shown that, with this subdivision, the 8th AJCC/UICC pTNM staging system (comprised of 25 subgroups of the T, N, and M categories) provided a more precise classification than those the 7th edition (comprised of 20 subgroups), emphasizing personalized treatment. However, among the recently published studies that had compared the prognosis prediction performance between the 8th and 7th editions, none focused on the homogeneity of both editions [12–15].
In the present study, 197 (2.5%) patients were upstaged and 1841 (23.2%) were downstaged as classified according to the 8th edition over the 7th edition of AJCC/UICC pTNM staging system in the training cohort, whereas 260 (2.5%) were upstaged and 1320 (12.9%) were downstaged in the external validation cohort. We also observed that the majority of stage migration occurred for stage III patients (99%, data not shown) in both cohorts, whereas only 1% was observed for stage II patients (T1N3b and T2N3b). As such, the present study was mainly focused on patients with stage III disease.
Furthermore, our analyses revealed that the 8th edition had better discriminatory ability and monotonicity than did the 7th edition in both cohorts, which was consistent with the results reported by IGCA . However, Kaplan–Meier analyses indicated significant differences in OS among the subgroups of patients within stage IIIA, IIIB, or IIIC classified according to either of the two staging editions. This poor homogeneity was significantly improved in our modified pTNM staging system.
Although our proposed modified pTNM staging system was shown to be superior to the 7th and 8th AJCC/UICC pTNM staging systems, there are certain limitations worth mentioning. First, our training cohort was based on a Chinese population database. Whether this proposed modified pTNM staging system is suitable for populations from other countries has yet to be verified. However, the treatment protocol for locally advanced GC of the same TNM category differs in Asian and Western cancer centers and may explain the observed lower 5-year OS rate in the external validation cohort as compared with that in the training cohort. Neoadjuvant therapies followed by radical resection (including D1 or D1+ lymphadenectomy) are conventionally opted in the west; however, in Asian cancer centers, radical surgery (D2 lymphadenectomy) followed by adjuvant therapy are primarily considered. Therefore, to extend the possible use of our proposed modified pTNM staging system, we used the SEER database for external validation. Additionally, to the best of our knowledge, the sample size of the training cohort, came from three highest-capacity GC centers across North and South China, is the largest among all such studies. This further supports the reliability of the results of the present study. Additionally, despite the difference in OS between the training and external validation cohorts that may have been caused by distinct demographic features, different lymphadenectomy types and pathological variables, the proposed modified pTNM staging system can still be universally applied in the West because it was successfully validated in a large external validation cohort from the SEER database. Second, the sample sizes of some subgroups classified according to the 8th AJCC/UICC pTNM staging system were relatively small [for instance, T1N3b (0% in the training cohort and 0.05% in the external validation cohort) and T2N3b (1.0% in the training cohort and 0.2% in the external validation cohort)], possibly due to the low rate of LN metastasis in patients at stage T1 or T2, and may have influenced the efficiency of comparison. Therefore, a study with a much larger sample size is required to further confirm the findings of the present study. Third, due to the retrospective nature of the present study, tumors involving the esophagogastric junction (EGJ) were not included in our analysis because the distances of their epicenters from the EGJ were not specifically mentioned in the retrieved Chinese and SEER databases.
Using large cohorts of patients from Chinese cancer centers and the SEER database, our results identified that both the 7th and 8th AJCC/UICC pTNM staging systems still possess poor homogeneity, particularly for stage III GC patients, although the homogeneity, discriminatory ability, and monotonicity of gradients are improved in the 8th edition. A modified pTNM staging system for GC was thereby proposed and validated, demonstrating superior stratification and prognosis prediction ability and suggesting high potential for clinical application in different populations.
Conception and design: CF, ZW, HX, HL, and ZZ. Collection and assembly of data: WW, SRS, JD, and ZS. Data analysis and interpretation: WW. Manuscript writing: CF, WW, and SRS. All authors read and approved the final manuscript.
The authors thank Medbanks (Beijing) Network Technology Co. Ltd for facilitating data collection, entry, and management.
The authors declare that they have no competing interests.
Availability of data and materials
The key raw data have been deposited into the Research Data Deposit (www.researchdata.org.cn) with the Approval Number of 2018000773.
Consent for publication
Ethics approval and consent to participate
Each patient provided written informed consent before treatment, and the study protocol was approved by the institutional review boards of SYSU, TJMU, and CMU.
This work was supported by the Major Program of Collaborative Innovation of Guangzhou (No. 201508030042), the Natural Science Foundation of Guangdong Province (No. 2015A030313089, 2018A030313631), Guangdong Provincial Scientific and Technology Project (No. 2014A020232331), Guangzhou Medical, Health Science and Technology Project (No. 20151A011077), China Postdoctoral Science Foundation Grant (No. 2017M622879), and National Natural Science Foundation of China (No. 81802451).
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- Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87–108. https://doi.org/10.3322/caac.21262.View ArticlePubMedPubMed CentralGoogle Scholar
- Zheng R, Zeng H, Zhang S, Chen W. Estimates of cancer incidence and mortality in China, 2013. Chin J Cancer. 2017;36(1):66. https://doi.org/10.1186/s40880-017-0234-3.View ArticlePubMedPubMed CentralGoogle Scholar
- Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66(2):115–32. https://doi.org/10.3322/caac.21338.View ArticlePubMedPubMed CentralGoogle Scholar
- Chen W, Zheng R, Zeng H, Zhang S. The incidence and mortality of major cancers in China, 2012. Chin J Cancer. 2016;35(1):73. https://doi.org/10.1186/s40880-016-0137-8.View ArticlePubMedPubMed CentralGoogle Scholar
- Ajani JA, D’Amico TA, Almhanna K, Bentrem DJ, Chao J, Das P, et al. Gastric cancer version 3.2016, NCCN clinical practice guidelines in oncology. J Natl Compr Cancer Netw. 2016;14(10):1286–312.View ArticleGoogle Scholar
- Amin MB, Edge S, Greene F, Byrd DR, Brookland RK, Washington MK, Gershenwald JE, Compton CC, Hess KR, Sullivan DC, Jessup JM, Brierley JD, Gaspar LE, Schilsky RL, Balch CM, Winchester DP, Asare EA, Madera M, Gress DM, Meyer LR. The 8th edition of the AJCC cancer staging manual. New York: Springer; 2017.View ArticleGoogle Scholar
- Edge S, Byrd DR, Compton CC, Fritz AG, Greene F, Trotti A. The 7th AJCC cancer staging handbook. New York: Springer; 2010.Google Scholar
- Japanese Gastric Cancer A. Japanese gastric cancer treatment guidelines 2014 (ver. 4). Gastric Cancer. 2017;20(1):1–19.View ArticleGoogle Scholar
- Wang W, Sun XW, Li CF, Lv L, Li YF, Chen YB, et al. Comparison of the 6th and 7th editions of the UICC TNM staging system for gastric cancer: results of a Chinese single-institution study of 1,503 patients. Ann Surg Oncol. 2011;18(4):1060–7. https://doi.org/10.1245/s10434-010-1424-2.View ArticlePubMedGoogle Scholar
- Greene FL, Sobin LH. The staging of cancer: a retrospective and prospective appraisal. CA Cancer J Clin. 2008;58(3):180–90. https://doi.org/10.3322/CA.2008.0001.View ArticlePubMedGoogle Scholar
- Wang W, Sun Z, Deng JY, Qi XL, Feng XY, Fang C, et al. A novel nomogram individually predicting disease-specific survival after D2 gastrectomy for advanced gastric cancer. Cancer Commun. 2018;38(1):23. https://doi.org/10.1186/s40880-018-0293-0.View ArticleGoogle Scholar
- In H, Solsky I, Palis B, Langdon-Embry M, Ajani J, Sano T. Validation of the 8th edition of the AJCC TNM staging system for gastric cancer using the national cancer database. Ann Surg Oncol. 2017;24(12):3683–91. https://doi.org/10.1245/s10434-017-6078-x.View ArticlePubMedGoogle Scholar
- Ji X, Bu ZD, Yan Y, Li ZY, Wu AW, Zhang LH, et al. The 8th edition of the American joint committee on cancer tumor-node-metastasis staging system for gastric cancer is superior to the 7th edition: results from a Chinese mono-institutional study of 1663 patients. Gastric Cancer. 2017. https://doi.org/10.1007/s10120-017-0779-5.View ArticlePubMedPubMed CentralGoogle Scholar
- Lu J, Zheng CH, Cao LL, Ling SW, Li P, Xie JW, et al. Validation of the American joint commission on cancer (8th edition) changes for patients with stage III gastric cancer: survival analysis of a large series from a specialized eastern center. Cancer Med. 2017;6(10):2179–87. https://doi.org/10.1002/cam4.1118.View ArticlePubMedPubMed CentralGoogle Scholar
- Seeruttun SR, Yuan S, Qiu H, Huang Y, Li Y, Liang Y, et al. A comprehensive analysis comparing the eighth AJCC gastric cancer pathological classification to the seventh, sixth, and fifth editions. Cancer Med. 2017;6(12):2804–13. https://doi.org/10.1002/cam4.1230.View ArticlePubMedPubMed CentralGoogle Scholar
- Sano T, Coit DG, Kim HH, Roviello F, Kassab P, Wittekind C, et al. Proposal of a new stage grouping of gastric cancer for TNM classification: international gastric cancer association staging project. Gastric Cancer. 2017;20(2):217–25. https://doi.org/10.1007/s10120-016-0601-9.View ArticlePubMedGoogle Scholar