Proposal and validation of a modified staging system to improve the prognosis predictive performance of the 8th AJCC/UICC pTNM staging system for gastric adenocarcinoma: a multicenter study with external validation

Table 2 Multivariate survival analyses of the training and external validation cohorts of gastric cancer patients

Variable	The 7th AJCC/UICC staging system			The 8th AJCC/UICC staging system			The modified staging system
Variable	P value	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI
Training cohort
Age	< 0.001	1.017	1.014–1.020	< 0.001	1.018	1.015–1.021	< 0.001	1.017	1.014–1.020
Tumor size	< 0.001	1.058	1.045–1.071	< 0.001	1.055	1.042–1.068	< 0.001	1.056	1.043–1.069
Tumor location	< 0.001	1.093	1.058–1.129	< 0.001	1.105	1.070–1.141	< 0.001	1.105	1.070–1.142
Lauren type	< 0.001	1.178	1.098–1.265	< 0.001	1.183	1.102–1.270	< 0.001	1.170	1.090–1.256
pTNM stage	< 0.001	1.547	1.511–1.584	< 0.001	1.644	1.601–1.687	< 0.001	1.575	1.538–1.612
External validation cohort
Age	< 0.001	1.030	1.028–1.032	< 0.001	1.030	1.028–1.033	< 0.001	1.030	1.028–1.032
Tumor size	0.037	1.001	1.000–1.002	0.067			0.020	1.001	1.000–1.002
Tumor location	< 0.001	1.106	1.072–1.141	< 0.001	1.109	1.076–1.143	< 0.001	1.105	1.071–1.140
Lauren type	< 0.001	1.182	1.113–1.255	< 0.001	1.189	1.120–1.262	< 0.001	1.169	1.101–1.241
pTNM stage	< 0.001	1.387	1.364–1.411	< 0.001	1.432	1.408–1.456	< 0.001	1.387	1.363–1.410

HR hazard ratio, CI confidence interval, p pathological classification, TNM tumor-node-metastasis staging system

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