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Table 2 Multivariate survival analyses of the training and external validation cohorts of gastric cancer patients

From: Proposal and validation of a modified staging system to improve the prognosis predictive performance of the 8th AJCC/UICC pTNM staging system for gastric adenocarcinoma: a multicenter study with external validation

Variable The 7th AJCC/UICC staging system The 8th AJCC/UICC staging system The modified staging system
P value HR 95% CI P value HR 95% CI P value HR 95% CI
Training cohort
 Age < 0.001 1.017 1.014–1.020 < 0.001 1.018 1.015–1.021 < 0.001 1.017 1.014–1.020
 Tumor size < 0.001 1.058 1.045–1.071 < 0.001 1.055 1.042–1.068 < 0.001 1.056 1.043–1.069
 Tumor location < 0.001 1.093 1.058–1.129 < 0.001 1.105 1.070–1.141 < 0.001 1.105 1.070–1.142
 Lauren type < 0.001 1.178 1.098–1.265 < 0.001 1.183 1.102–1.270 < 0.001 1.170 1.090–1.256
 pTNM stage < 0.001 1.547 1.511–1.584 < 0.001 1.644 1.601–1.687 < 0.001 1.575 1.538–1.612
External validation cohort
 Age < 0.001 1.030 1.028–1.032 < 0.001 1.030 1.028–1.033 < 0.001 1.030 1.028–1.032
 Tumor size 0.037 1.001 1.000–1.002 0.067    0.020 1.001 1.000–1.002
 Tumor location < 0.001 1.106 1.072–1.141 < 0.001 1.109 1.076–1.143 < 0.001 1.105 1.071–1.140
 Lauren type < 0.001 1.182 1.113–1.255 < 0.001 1.189 1.120–1.262 < 0.001 1.169 1.101–1.241
 pTNM stage < 0.001 1.387 1.364–1.411 < 0.001 1.432 1.408–1.456 < 0.001 1.387 1.363–1.410
  1. HR hazard ratio, CI confidence interval, p pathological classification, TNM tumor-node-metastasis staging system