Table 1 Clinicopathologic variables and univariate analysis of the Chinese training cohort and SEER external validation cohort of gastric cancer patients
Variable | Training cohort (n = 7911) | External validation cohort (n = 10,208) | ||||
|---|---|---|---|---|---|---|
No. of patients [cases (%)] | 5-year OS rate (%) | P value | No. of patients [cases (%)] | 5-year OS rate (%) | P value | |
Age (years) | < 0.001 | < 0.001 | ||||
≤ 59 | 4117 (52.0) | 57.6 | 5142 (50.4) | 47.1 | ||
> 59 | 3794 (48.0) | 48.0 | 5066 (49.6) | 34.9 | ||
Gender | 0.108 | 0.082 | ||||
Male | 5586 (70.6) | 52.5 | 6360 (62.3) | 40.1 | ||
Female | 2325 (29.4) | 54.3 | 3848 (37.7) | 42.3 | ||
Tumor location | < 0.001 | < 0.001 | ||||
Antrum | 3578 (45.2) | 61.4 | 3382 (33.1) | 43.2 | ||
Body | 1523 (19.3) | 50.5 | 2701 (26.5) | 47.2 | ||
Cardia/fundus | 2144 (27.1) | 47.7 | 3694 (36.2) | 36.9 | ||
Whole stomach | 666 (8.4) | 30.7 | 431 (4.2) | 19.1 | ||
Tumor size (cm) | < 0.001 | < 0.001 | ||||
≤ 4.5 | 4081 (51.6) | 65.5 | 5086 (49.8) | 51.4 | ||
> 4.5 | 3830 (48.4) | 39.9 | 5122 (50.2) | 31.1 | ||
Lauren type | < 0.001 | < 0.001 | ||||
Intestinal | 3329 (42.1) | 59.7 | 4062 (39.8) | 47.7 | ||
Diffuse | 4582 (57.9) | 48.2 | 6146 (60.2) | 36.6 | ||
pT stage | < 0.001 | < 0.001 | ||||
T1 | 954 (12.1) | 95.6 | 2172 (21.3) | 72.3 | ||
T2 | 1447 (18.3) | 66.4 | 1402 (13.7) | 55.0 | ||
T3 | 1291 (16.3) | 53.2 | 3901 (38.2) | 33.4 | ||
T4a | 3675 (46.5) | 40.6 | 2061 (20.2) | 22.5 | ||
T4b | 544 (6.9) | 26.8 | 672 (6.6) | 18.4 | ||
pN stage | < 0.001 | < 0.001 | ||||
N0 | 2870 (36.3) | 79.6 | 4014 (39.3) | 62.3 | ||
N1 | 1403 (17.7) | 57.6 | 2069 (20.3) | 40.4 | ||
N2 | 1547 (19.6) | 44.0 | 1849 (18.1) | 30.0 | ||
N3a | 1407 (17.8) | 24.2 | 1654 (16.2) | 16.4 | ||
N3b | 684 (8.6) | 14.1 | 622 (6.1) | 8.9 | ||
pTNM stage (7th ed.) | < 0.001 | < 0.001 | ||||
IA | 801 (10.1) | 96.6 | 1718 (16.8) | 76.6 | ||
IB | 735 (9.3) | 84.4 | 1048 (10.3) | 62.5 | ||
IIA | 699 (8.8) | 75.5 | 1507 (14.8) | 51.3 | ||
IIB | 1499 (18.9) | 63.0 | 1512 (14.8) | 38.1 | ||
IIIA | 1248 (15.8) | 46.6 | 1410 (13.8) | 29.6 | ||
IIIB | 1352 (17.1) | 35.8 | 1777 (17.4) | 20.9 | ||
IIIC | 1577 (19.9) | 17.4 | 1236 (12.1) | 10.9 | ||
pTNM stage (8th ed.) | < 0.001 | < 0.001 | ||||
IA | 801 (10.1) | 96.6 | 1718 (16.8) | 76.6 | ||
IB | 735 (9.3) | 84.4 | 1048 (10.3) | 62.5 | ||
IIA | 699 (8.8) | 75.5 | 1507 (14.8) | 51.3 | ||
IIB | 1499 (18.9) | 63.0 | 1507 (14.8) | 38.2 | ||
IIIA | 2076 (26.2) | 44.5 | 2012 (19.7) | 28.5 | ||
IIIB | 1340 (16.9) | 23.2 | 1643 (16.1) | 16.9 | ||
IIIC | 761 (9.6) | 13.6 | 773 (7.6) | 8.1 | ||
pTNM stage (modified) | < 0.001 | < 0.001 | ||||
IA | 801 (10.1) | 96.6 | 1718 (16.8) | 76.6 | ||
IB | 735 (9.3) | 84.4 | 1048 (10.3) | 62.5 | ||
IIA | 699 (8.8) | 75.5 | 1507 (14.8) | 51.3 | ||
IIB | 1499 (18.9) | 63.0 | 1507 (14.8) | 38.2 | ||
IIIA | 1078 (13.6) | 50.9 | 1420 (13.9) | 30.3 | ||
IIIB | 1447 (18.3) | 36.9 | 1668 (16.3) | 21.7 | ||
IIIC | 1652 (20.9) | 16.0 | 1340 (13.1) | 9.7 | ||