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Table 1 Clinicopathologic variables and univariate analysis of the Chinese training cohort and SEER external validation cohort of gastric cancer patients

From: Proposal and validation of a modified staging system to improve the prognosis predictive performance of the 8th AJCC/UICC pTNM staging system for gastric adenocarcinoma: a multicenter study with external validation

Variable Training cohort (n = 7911) External validation cohort (n = 10,208)
No. of patients [cases (%)] 5-year OS rate (%) P value No. of patients [cases (%)] 5-year OS rate (%) P value
Age (years) < 0.001    < 0.001
 ≤ 59 4117 (52.0) 57.6   5142 (50.4) 47.1  
 > 59 3794 (48.0) 48.0   5066 (49.6) 34.9  
Gender 0.108    0.082
 Male 5586 (70.6) 52.5   6360 (62.3) 40.1  
 Female 2325 (29.4) 54.3   3848 (37.7) 42.3  
Tumor location < 0.001    < 0.001
 Antrum 3578 (45.2) 61.4   3382 (33.1) 43.2  
 Body 1523 (19.3) 50.5   2701 (26.5) 47.2  
 Cardia/fundus 2144 (27.1) 47.7   3694 (36.2) 36.9  
 Whole stomach 666 (8.4) 30.7   431 (4.2) 19.1  
Tumor size (cm) < 0.001    < 0.001
 ≤ 4.5 4081 (51.6) 65.5   5086 (49.8) 51.4  
 > 4.5 3830 (48.4) 39.9   5122 (50.2) 31.1  
Lauren type < 0.001    < 0.001
 Intestinal 3329 (42.1) 59.7   4062 (39.8) 47.7  
 Diffuse 4582 (57.9) 48.2   6146 (60.2) 36.6  
pT stage < 0.001    < 0.001
 T1 954 (12.1) 95.6   2172 (21.3) 72.3  
 T2 1447 (18.3) 66.4   1402 (13.7) 55.0  
 T3 1291 (16.3) 53.2   3901 (38.2) 33.4  
 T4a 3675 (46.5) 40.6   2061 (20.2) 22.5  
 T4b 544 (6.9) 26.8   672 (6.6) 18.4  
pN stage < 0.001    < 0.001
 N0 2870 (36.3) 79.6   4014 (39.3) 62.3  
 N1 1403 (17.7) 57.6   2069 (20.3) 40.4  
 N2 1547 (19.6) 44.0   1849 (18.1) 30.0  
 N3a 1407 (17.8) 24.2   1654 (16.2) 16.4  
 N3b 684 (8.6) 14.1   622 (6.1) 8.9  
pTNM stage (7th ed.) < 0.001    < 0.001
 IA 801 (10.1) 96.6   1718 (16.8) 76.6  
 IB 735 (9.3) 84.4   1048 (10.3) 62.5  
 IIA 699 (8.8) 75.5   1507 (14.8) 51.3  
 IIB 1499 (18.9) 63.0   1512 (14.8) 38.1  
 IIIA 1248 (15.8) 46.6   1410 (13.8) 29.6  
 IIIB 1352 (17.1) 35.8   1777 (17.4) 20.9  
 IIIC 1577 (19.9) 17.4   1236 (12.1) 10.9  
pTNM stage (8th ed.) < 0.001    < 0.001
 IA 801 (10.1) 96.6   1718 (16.8) 76.6  
 IB 735 (9.3) 84.4   1048 (10.3) 62.5  
 IIA 699 (8.8) 75.5   1507 (14.8) 51.3  
 IIB 1499 (18.9) 63.0   1507 (14.8) 38.2  
 IIIA 2076 (26.2) 44.5   2012 (19.7) 28.5  
 IIIB 1340 (16.9) 23.2   1643 (16.1) 16.9  
 IIIC 761 (9.6) 13.6   773 (7.6) 8.1  
pTNM stage (modified) < 0.001    < 0.001
 IA 801 (10.1) 96.6   1718 (16.8) 76.6  
 IB 735 (9.3) 84.4   1048 (10.3) 62.5  
 IIA 699 (8.8) 75.5   1507 (14.8) 51.3  
 IIB 1499 (18.9) 63.0   1507 (14.8) 38.2  
 IIIA 1078 (13.6) 50.9   1420 (13.9) 30.3  
 IIIB 1447 (18.3) 36.9   1668 (16.3) 21.7  
 IIIC 1652 (20.9) 16.0   1340 (13.1) 9.7  
  1. p pathological, TNM tumor-node-metastasis, ed. edition