Articles

Expert consensus on maintenance treatment for metastatic colorectal cancer in China

The impact of maintenance therapy on progression-free survival and overall survival as well as quality of life of Chinese patients with metastatic colorectal cancer has long been under discussion. Recently, s...

Authors: Rui-Hua Xu, Lin Shen, Jin Li, Jian-Ming Xu, Feng Bi, Yi Ba, Li Bai, Yong-Qian Shu, Tian-Shu Liu, Yu-Hong Li, Chun-Mei Bai, Xiang-Lin Yuan, Jun Zhang, Gong Chen, Ai-Ping Zhou, Ying Yuan…

Genomic profiling of lower-grade gliomas uncovers cohesive disease groups: implications for diagnosis and treatment

Lower-grade gliomas (including low- and intermediate-grade gliomas, World Health Organization grades II and III) are diffusely infiltrative neoplasms that arise most often in the cerebral hemispheres of adults...

Authors: Chang-Ming Zhang and Daniel J. Brat

Cumulative scores based on plasma D-dimer and serum albumin levels predict survival in esophageal squamous cell carcinoma patients treated with transthoracic esophagectomy

Recently, studies have shown that plasma D-dimer and serum albumin are prognostic markers for esophageal cancer. The purpose of this study was to evaluate a novel prognostic scoring system—DA score (combinatio...

Authors: De-Qing Liu, Fang-Fang Li and Wei-Hua Jia

Revisiting tumor angiogenesis: vessel co-option, vessel remodeling, and cancer cell-derived vasculature formation

Tumor growth and metastasis depend on the establishment of tumor vasculature to provide oxygen, nutrients, and other essential factors. The well-known vascular endothelial growth factor (VEGF) signaling is cru...

Authors: Chao-Nan Qian, Min-Han Tan, Jun-Ping Yang and Yun Cao

Carcinogenesis of nasopharyngeal carcinoma: an alternate hypothetical mechanism

Current proposed mechanisms implicate both early and latent Epstein–Barr virus (EBV) infection in the carcinogenic cascade, whereas epidemiological studies have always associated nasopharyngeal carcinoma (NPC)...

Authors: Sharon Shuxian Poh, Melvin Lee Kiang Chua and Joseph T. S. Wee

Phase II study of oxaliplatin combined with S-1 and leucovorin (SOL) for Chinese patients with metastatic colorectal cancer

Fluoropyrimidine and oxaliplatin are widely used for patients with colorectal cancer. This phase II study was conducted to evaluate the efficacy and safety of the combination of S-1, oxaliplatin, and leucovor...

Authors: Zhi-Qiang Wang, Dong-Sheng Zhang, Nong Xu, De-Yun Luo, Yan-Hong Deng, Feng-Hua Wang, Hui-Yan Luo, Miao-Zhen Qiu, Yu-Hong Li and Rui-Hua Xu

Resectable left lower lobe non–small cell lung cancer with lymph node metastasis is related to unfavorable outcomes

Despite numerous previous studies, the consideration of tumor location as a prognostic factor in resectable non–small cell lung cancer (NSCLC) remains controversial. The present study analyzed the associatio...

Authors: Wen-Feng Ye, Xuan Xie, Hong Yang, Kong-Jia Luo, Qian-Wen Liu, Yu-Zhen Zheng and Jun-Ye Wang

Roles of low-density lipoprotein receptor-related protein 1 in tumors

Low-density lipoprotein receptor-related protein 1 (LRP1, also known as CD91), a multifunctional endocytic and cell signaling receptor, is widely expressed on the surface of multiple cell types such as hepatoc...

Authors: Peipei Xing, Zhichao Liao, Zhiwu Ren, Jun Zhao, Fengju Song, Guowen Wang, Kexin Chen and Jilong Yang

Prognostic significance of the pre-chemotherapy lymphocyte-to-monocyte ratio in patients with previously untreated metastatic colorectal cancer receiving FOLFOX chemotherapy

As a surrogate marker of systemic inflammation, the lymphocyte-to-monocyte ratio (LMR) is an independent prognostic factor for various malignancies. This study investigated the prognostic significance of the p...

Authors: Gui-Nan Lin, Pan-Pan Liu, Dong-Ying Liu, Jie-Wen Peng, Jian-Jun Xiao and Zhong-Jun Xia

Molecular pathogenesis of sporadic colorectal cancers

Colorectal cancer (CRC) results from the progressive accumulation of genetic and epigenetic alterations that lead to the transformation of normal colonic mucosa to adenocarcinoma. Approximately 75% of CRCs are...

Authors: Hidetsugu Yamagishi, Hajime Kuroda, Yasuo Imai and Hideyuki Hiraishi

Differentiation therapy: a promising strategy for cancer treatment

Poor differentiation is an important hallmark of cancer cells, and differentiation therapy holds great promise for cancer treatment. The restoration of IkB kinase α (IKKα) leads to the differentiation of nasop...

Authors: Min Yan and Quentin Liu

Neoadjuvant chemotherapy plus intensity-modulated radiotherapy versus concurrent chemoradiotherapy plus adjuvant chemotherapy for the treatment of locoregionally advanced nasopharyngeal carcinoma: a retrospective controlled study

In the era of intensity-modulated radiotherapy (IMRT), the role of neoadjuvant chemotherapy (NAC) for locoregionally advanced nasopharyngeal carcinoma (NPC) is under-evaluated. The aim of this study was to com...

Authors: Wen-Ze Qiu, Pei-Yu Huang, Jun-Li Shi, Hai-Qun Xia, Chong Zhao and Ka-Jia Cao

Occipital lymph node metastasis from nasopharyngeal carcinoma: a special case report and literature review

Cervical lymph node metastasis is common in patients with nasopharyngeal carcinoma (NPC), but occipital lymph node metastasis in NPC patients has not yet been reported. In this case report, we describe an NPC ...

Authors: Jing Yang, Wei-Xiong Xia, Yan-Qun Xiang, Xing Lv, Liang-Ru Ke, Ya-Hui Yu and Xiang Guo

Award for outstanding contributions to the Chinese Journal of Cancer

At the 4th Guangzhou International Symposium on Oncology, Rui-Hua Xu, Chao-Nan Qian, and Wei Zhang—the chairmen and editors of the Chinese Journal of Cancer—announced and presented awards to 14 authors in recogni...

Authors: Ji Ruan

A single nucleotide polymorphism in the Epstein-Barr virus genome is strongly associated with a high risk of nasopharyngeal carcinoma

Epstein-Barr virus (EBV) commonly infects the general population and has been associated with nasopharyngeal carcinoma (NPC), which has a high incidence in certain regions. This study aimed to address how EBV ...

Authors: Fu-Tuo Feng, Qian Cui, Wen-Sheng Liu, Yun-Miao Guo, Qi-Sheng Feng, Li-Zhen Chen, Miao Xu, Bing Luo, Da-Jiang Li, Li-Fu Hu, Jaap M. Middeldorp, Octavia Ramayanti, Qian Tao, Su-Mei Cao, Wei-Hua Jia, Jin-Xin Bei…

SHMT1 C1420T polymorphism contributes to the risk of non-Hodgkin lymphoma: evidence from 7309 patients

Serine hydroxymethyltransferase 1 (SHMT1) is a key enzyme in the folate metabolic pathway that plays an important role in biosynthesis by providing one carbon unit. SHMT1 C1420T may lead to the abnormal biosynthe...

Authors: Yi-Wei Wang, Shao-Dan Zhang, Wen-Ji Xue, Mei-Ling Zhu and Lei-Zhen Zheng

Prognostic values of interim and post-therapy ¹⁸F-FDG PET/CT scanning in adult patients with Burkitt’s lymphoma

The prognostic values of interim and post-therapy fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET) and PET/computed tomography (CT) scanning have been confirmed in several subtypes of l...

Authors: Wen-Xiao Wei, Jia-Jia Huang, Wen-Yu Li, Xu Zhang, Yi Xia, Wen-Qi Jiang, Wei Fan and Zhi-Ming Li

Estimation of cancer burden in Guangdong Province, China in 2009

Surveying regional cancer incidence and mortality provides significant data that can assist in making health policy for local areas; however, the province- and region-based cancer burden in China is seldom rep...

Authors: Su-Mei Cao, Yan-Jun Xu, Guo-Zhen Lin, Qi-Hong Huang, Kuang-Rong Wei, Shang-Hang Xie and Qing Liu

Long-term survival trends of gastric cancer patients between 1972 and 2011 in Qidong

There have been few reports on long-term survival of gastric cancer patients. This study analyzed the survival data of gastric cancer patients obtained from the population-based Qidong Cancer Registry between ...

Authors: Yong-Sheng Chen, Jian-Guo Chen, Jian Zhu, Yong-Hui Zhang and Lu-Lu Ding

Incidence and mortality of liver cancer in China in 2011

Liver cancer is a common cancer with poor prognosis in China. In this study, the national population-based cancer registration data were used to evaluate and analyze liver cancer incidence and mortality in Chi...

Authors: Ting-Ting Zuo, Rong-Shou Zheng, Si-Wei Zhang, Hong-Mei Zeng and Wan-Qing Chen

Structural analysis of tumor-related single amino acid mutations in human MxA protein

Human myxovirus resistant protein A (MxA), encoded by the myxovirus resistance 1 (Mx1) gene, is an interferon (IFN)-triggered dynamin-like multi-domain GTPase involved in innate immune responses against viral inf...

Authors: Jia-Li Hu, Yi-Jun Hua, Yang Chen, Bing Yu and Song Gao

Prognostic role of the ABO blood types in Chinese patients with curatively resected non-small cell lung cancer: a retrospective analysis of 1601 cases at a single cancer center

A positive association between the ABO blood types and survival has been suggested in several malignancies. The aim of this study was to assess the role of the ABO blood types in predicting the prognosis of Ch...

Authors: Ning Li, Miao Xu, Chao-Feng Li, Wei Ou, Bao-Xiao Wang, Song-Liang Zhang, Peng-Fei Xu, Cheng Yuan, Qun-Ai Huang and Si-Yu Wang

The updated incidences and mortalities of major cancers in China, 2011

The National Central Cancer Registry (NCCR) of China collected population-based cancer registration data from all cancer registries in China. This study aimed to compile national cancer incidences and mortalit...

Authors: Wanqing Chen, Rongshou Zheng, Hongmei Zeng and Siwei Zhang

Autologous peripheral blood stem cell mobilization following dose-adjusted cyclophosphamide, doxorubicin, vincristine, and prednisolone chemotherapy alone or in combination with rituximab in treating high-risk non-Hodgkin’s lymphoma

The regimen of cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) is an efficient treatment of non-Hodgkin’s lymphoma (NHL). This study aimed to assess the efficacy and toxicity of dose-adjust...

Authors: Yuankai Shi, Ping Zhou, Xiaohong Han, Xiaohui He, Shengyu Zhou, Peng Liu, Jianliang Yang, Changgong Zhang, Lin Gui, Yan Qin, Sheng Yang, Liya Zhao, Jiarui Yao and Shuxiang Zhang

The prognostic value of Tiam1 protein expression in head and neck squamous cell carcinoma: a retrospective study

Head and neck squamous cell carcinoma (HNSCC) is a common cancer worldwide and has a poor prognosis. A biomarker predicting the clinical outcome of HNSCC patients could be useful in guiding treatment planning....

Authors: Hang Yang, Yu-Chen Cai, Ye Cao, Ming Song, Xin An, Yi Xia, Jing Wei, Wen-Qi Jiang and Yan-Xia Shi

Wnt3a: functions and implications in cancer

Wnt3a, one of Wnt family members, plays key roles in regulating pleiotropic cellular functions, including self-renewal, proliferation, differentiation, and motility. Accumulating evidence has suggested that Wn...

Authors: Sha He, Yi Lu, Xia Liu, Xin Huang, Evan T. Keller, Chao-Nan Qian and Jian Zhang

Brain metastasis in children with stage 4 neuroblastoma after multidisciplinary treatment

Brain metastasis is common in relapsed neuroblastoma patients, but the characteristics of brain metastasis remain largely unknown. This study aimed to investigate the status of brain metastasis with neuroblast...

Authors: Jia Zhu, Juan Wang, Zi-Jun Zhen, Su-Ying Lu, Fei Zhang, Fei-Fei Sun, Peng-Fei Li, Jun-Ting Huang, Rui-Qing Cai and Xiao-Fei Sun

A multilevel pan-cancer map links gene mutations to cancer hallmarks

A central challenge in cancer research is to create models that bridge the gap between the molecular level on which interventions can be designed and the cellular and tissue levels on which the disease phenot...

Authors: Theo A. Knijnenburg, Tycho Bismeijer, Lodewyk F. A. Wessels and Ilya Shmulevich

Association of insulin-like growth factor-binding protein-3 with radiotherapy response and prognosis of esophageal squamous cell carcinoma

Insulin-like growth factor-binding protein-3 (IGFBP-3) is suggested to predict the radiosensitivity and/or prognosis of patients with esophageal squamous cell carcinoma (ESCC). The present study was designed t...

Authors: Li-Ling Luo, Lei Zhao, Mian Xi, Li-Ru He, Jing-Xian Shen, Qiao-Qiao Li, Shi-Liang Liu, Peng Zhang, Dan Xie and Meng-Zhong Liu

Stem cell-derived exosomes: roles in stromal remodeling, tumor progression, and cancer immunotherapy

Stem cells are known to maintain stemness at least in part through secreted factors that promote stem-like phenotypes in resident cells. Accumulating evidence has clarified that stem cells release nano-vesicle...

Authors: Farah Fatima and Muhammad Nawaz

The reversal of antineoplastic drug resistance in cancer cells by β-elemene

Multidrug resistance (MDR), defined as the resistance of cancer cells to compounds with diverse structures and mechanisms of actions, significantly limits the efficacy of antitumor drugs. A major mechanism tha...

Authors: Guan-Nan Zhang, Charles R. Ashby Jr., Yun-Kai Zhang, Zhe-Sheng Chen and Huiqin Guo

miR-506: a regulator of chemo-sensitivity through suppression of the RAD51-homologous recombination axis

Ovarian carcinoma is the most lethal gynecologic malignancy. Resistance to platinum is considered the major problem affecting prognosis. Our recent study established that microRNA-506 (miR-506) expression was clo...

Authors: Guoyan Liu, Fengxia Xue and Wei Zhang

Targeted therapy: resistance and re-sensitization

The last two decades have witnessed a paradigm shift from cytotoxic drugs to targeted therapy in medical oncology and pharmaceutical innovation. Inspired by breakthroughs in molecular and cellular biology, a n...

Authors: Dao-Hong Chen and Xiao-Shi Zhang

Cytochrome b5 reductase 2 suppresses tumor formation in nasopharyngeal carcinoma by attenuating angiogenesis

Cytochrome b5 reductase 2 (CYB5R2) is a potential tumor suppressor that inhibits cell proliferation and motility in nasopharyngeal carcinoma (NPC). Inactivation of CYB5R2 is associated with lymph node metastas...

Authors: Huixin Ming, Ying Lan, Feng He, Xue Xiao, Xiaoying Zhou, Zhe Zhang, Ping Li and Guangwu Huang

Clinical parameters predicting pathologic complete response following neoadjuvant chemoradiotherapy for rectal cancer

Preoperative chemoradiotherapy (CRT), followed by total mesorectal excision, has become the standard of care for patients with clinical stages II and III rectal cancer. Patients with pathologic complete respon...

Authors: Wei-Gen Zeng, Jian-Wei Liang, Zheng Wang, Xing-Mao Zhang, Jun-Jie Hu, Hui-Rong Hou, Hai-Tao Zhou and Zhi-Xiang Zhou

Subdivision of M category for nasopharyngeal carcinoma with synchronous metastasis: time to expand the M categorization system

The current metastatic category (M) of nasopharyngeal carcinoma (NPC) is a “catch-all” classification, covering a heterogeneous group of tumors ranging from potentially curable to incurable. The aim of this st...

Authors: Lu-Jun Shen, Si-Yang Wang, Guo-Feng Xie, Qi Zeng, Chen Chen, An-Nan Dong, Zhi-Mei Huang, Chang-Chuan Pan, Yun-Fei Xia and Pei-Hong Wu

The prognostic value of serum C-reactive protein-bound serum amyloid A in early-stage lung cancer

Elevated levels of serum C-reactive protein (CRP) have been reported to have prognostic significance in lung cancer patients. This study aimed to further identify CRP-bound components as prognostic markers for...

Authors: Xue-Yan Zhang, Ge Zhang, Ying Jiang, Dan Liu, Man-Zhi Li, Qian Zhong, Shan-Qi Zeng, Wan-Li Liu and Mu-Sheng Zeng

Carcinogenic effects of circadian disruption: an epigenetic viewpoint

Circadian rhythms refer to the endogenous rhythms that are generated to synchronize physiology and behavior with 24-h environmental cues. These rhythms are regulated by both external cues and molecular clock m...

Authors: Abbas Salavaty

Can radical parametrectomy be omitted in occult cervical cancer after extrafascial hysterectomy?

Occult invasive cervical cancer discovered after simple hysterectomy is not common, radical parametrectomy (RP) is a preferred option for young women. However, the morbidity of RP was high. The aim of our stud...

Authors: Huai-Wu Lu, Jing Li, Yun-Yun Liu, Chang-Hao Liu, Guo-Cai Xu, Ling-Ling Xie, Miao-Fang Wu and Zhong-Qiu Lin

Effects of subsampling on characteristics of RNA-seq data from triple-negative breast cancer patients

Data from RNA-seq experiments provide a wealth of information about the transcriptome of an organism. However, the analysis of such data is very demanding. In this study, we aimed to establish robust analysis ...

Authors: Alexey Stupnikov, Galina V Glazko and Frank Emmert-Streib

Clinicopathologic characteristics and therapeutic responses of Chinese patients with non-small cell lung cancer who harbor an anaplastic lymphoma kinase rearrangement

The rearrangement of the anaplastic lymphoma kinase (ALK) gene accounts for approximately 1%–6% of lung adenocarcinoma cases and defines a molecular subgroup of tumors characterized by clinical sensitivity to ALK

Authors: Sha Fu, Hai-Yun Wang, Fang Wang, Ma-Yan Huang, Ling Deng, Xiao Zhang, Zu-Lu Ye and Jian-Yong Shao

Incidence trends and age distribution of colorectal cancer by subsite in Guangzhou, 2000–2011

Colorectal cancer (CRC) is the third most common cancer in China. The incidence of CRC has been increasing in recent years. The aim of this study was to explore the incidence trends and the age distribution of...

Authors: Qin Zhou, Ke Li, Guo-Zhen Lin, Ji-Chuan Shen, Hang Dong, Yu-Ting Gu and Hua-Zhang Liu

Secular trend analysis of lung cancer incidence in Sihui city, China between 1987 and 2011

With industrial and econom ic development in recent decades in South China, cancer incidence may have changed due to the changing lifestyle and environment. However, the trends of lung cancer and the roles of ...

Authors: Jin-Lin Du, Xiao Lin, Li-Fang Zhang, Yan-Hua Li, Shang-Hang Xie, Meng-Jie Yang, Jie Guo, Er-Hong Lin, Qing Liu, Ming-Huang Hong, Qi-Hong Huang, Zheng-Er Liao and Su-Mei Cao

Global efforts in conquering lung cancer in China

Lung cancer, the most prevalent and deadly malignancy in the world, poses a particularly critical healthcare challenge to China due to the rapidly increasing new cases and the unique cancer genetics in Chinese...

Authors: Li Yan and Li Xu

Targeted therapies for patients with advanced NSCLC harboring wild-type EGFR: what’s new and what’s enough

Historically, non-small cell lung cancer (NSCLC) is divided into squamous and nonsquamous subtypes based on histologic features. With a growing number of oncogenic drivers being identified in squamous and nons...

Authors: Fei Zhou and Cai-Cun Zhou

Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins

Ribosome-inactivating proteins (RIPs) belong to a family of enzymes that attack eukaryotic ribosomes and potently inhibit cellular protein synthesis. RIPs possess several biomedical properties, including anti-...

Authors: Meiqi Zeng, Manyin Zheng, Desheng Lu, Jun Wang, Wenqi Jiang and Ou Sha

Insight into early-phase trials for lung cancer in the United States

Few data have been published comparing early-phase trials for lung cancer between China and the United States (US). This study was to investigate the differences of phase 1 trials for lung cancer between these...

Authors: Jin-Ji Yang and Yi-Long Wu

Early-Phase Oncology Research Training (EFFORT) program: a Hengrui-USCACA joint scholarship

Authors: Li Yan and Li Xu

Parallel phase 1 clinical trials in the US and in China: accelerating the test of avitinib in lung cancer as a novel inhibitor selectively targeting mutated EGFR and overcoming T790M-induced resistance

Avitinib, a new generation inhibitor of epidermal growth factor receptor (EGFR), was approved for clinical trial in both China and the United States, and the phase 1 trials were initiated in both countries in ...

Authors: Xiao Xu

Predictive biomarkers in precision medicine and drug development against lung cancer

The molecular characterization of various cancers has shown that cancers with the same origins, histopathologic diagnoses, and clinical stages can be highly heterogeneous in their genetic and epigenetic altera...

Authors: Bingliang Fang, Reza J Mehran, John V Heymach and Stephen G Swisher