Lim CB, Ky N, Ng HM, Hamza MS, Zhao Y. Curcuma wenyujin extract induces apoptosis and inhibits proliferation of human cervical cancer cells in vitro and in vivo. Integr Cancer Ther. 2010;9(1):36–49. doi:10.1177/1534735409359773.
Article
PubMed
Google Scholar
Lai EY, Chyau CC, Mau JL, Chen CC, Lai YJ, Shih CF, et al. Antimicrobial activity and cytotoxicity of the essential oil of Curcuma zedoaria. Am J Chin Med. 2004;32(2):281–90. doi:10.1142/S0192415X0400193X.
Article
CAS
PubMed
Google Scholar
Tohda C, Nakayama N, Hatanaka F, Komatsu K. Comparison of anti-inflammatory activities of six Curcuma rhizomes: a possible curcuminoid-independent pathway mediated by Curcuma
phaeocaulis extract. Evid Based Complement Alternat Med. 2006;3(2):255–60. doi:10.1093/ecam/nel008.
Article
PubMed Central
PubMed
Google Scholar
Maheshwari RK, Singh AK, Gaddipati J, Srimal RC. Multiple biological activities of curcumin: a short review. Life Sci. 2006;78(18):2081–7. doi:10.1016/j.lfs.2005.12.007.
Article
CAS
PubMed
Google Scholar
Makabe H, Maru N, Kuwabara A, Kamo T, Hirota M. Anti-inflammatory sesquiterpenes from Curcuma zedoaria. Nat Prod Res. 2006;20(7):680–5. doi:10.1080/14786410500462900.
Article
CAS
PubMed
Google Scholar
Park SD, Jung JH, Lee HW, Kwon YM, Chung KH, Kim MG, et al. Zedoariae rhizoma and curcumin inhibits platelet-derived growth factor-induced proliferation of human hepatic myofibroblasts. Int Immunopharmacol. 2005;5(3):555–69. doi:10.1016/j.intimp.2004.11.003.
Article
CAS
PubMed
Google Scholar
Zhang J, Zhang H, Chen L, da Sun W, Mao C, Chen W, et al. β-Elemene reverses chemoresistance of breast cancer via regulating MDR-related microRNA expression. Cell Physiol Biochem. 2014;34(6):2027–37. doi:10.1159/000366398.
Article
CAS
PubMed
Google Scholar
Lee RX, Li QQ, Reed E. β-Elemene effectively suppresses the growth and survival of both platinum-sensitive and -resistant ovarian tumor cells. Anticancer Res. 2012;32(8):3103–13.
PubMed Central
CAS
PubMed
Google Scholar
Zheng S, Yang H, Zhang S, Wang X, Yu L, Lu J, et al. Initial study on naturally occurring products from traditional Chinese herbs and vegetables for chemoprevention. J Cell Biochem Suppl. 1997;27:106–12.
Article
CAS
PubMed
Google Scholar
Zhou HY, Shen JK, Hou JS, Qiu YM, Luo QZ. Experimental study on apoptosis induced by elemene in glioma cells. Ai Zheng. 2003;22(9):959–63 (in Chinese).
CAS
PubMed
Google Scholar
Wang G, Li X, Huang F, Zhao J, Ding H, Cunningham C, et al. Antitumor effect of beta-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death. Cell Mol Life Sci. 2005;62(7–8):881–93. doi:10.1007/s00018-005-5017-3.
Article
CAS
PubMed
Google Scholar
Li X, Wang G, Zhao J, Ding H, Cunningham C, Chen F, et al. Antiproliferative effect of beta-elemene in chemoresistant ovarian carcinoma cells is mediated through arrest of the cell cycle at the G2-M phase. Cell Mol Life Sci. 2005;62(7–8):894–904. doi:10.1007/s00018-005-5027-1.
Article
CAS
PubMed
Google Scholar
Zhao J, Li QQ, Zou B, Wang G, Li X, Kim JE, et al. In vitro combination characterization of the new anticancer plant drug beta-elemene with taxanes against human lung carcinoma. Int J Oncol. 2007;31(2):241–52.
CAS
PubMed
Google Scholar
Li QQ, Wang G, Zhang M, Cuff CF, Huang L, Reed E. beta-Elemene, a novel plant-derived antineoplastic agent, increases cisplatin chemosensitivity of lung tumor cells by triggering apoptosis. Oncol Rep. 2009;22(1):161–70.
Article
CAS
PubMed
Google Scholar
Kishi S, Ueda T. Chemotherapy. Nihon Rinsho. 2014;72(3):462–7 (in Japanese).
PubMed
Google Scholar
Gottesman MM. How cancer cells evade chemotherapy: sixteenth Richard and Hinda Rosenthal Foundation Award Lecture. Cancer Res. 1993;53(4):747–54.
CAS
PubMed
Google Scholar
Gillet JP, Gottesman MM. Mechanisms of multidrug resistance in cancer. Methods Mol Biol. 2010;596:47–76. doi:10.1007/978-1-60761-416-6_4.
Article
CAS
PubMed
Google Scholar
Seitz G, Bonin M, Fuchs J, Poths S, Ruck P, Warmann SW, et al. Inhibition of glutathione-S-transferase as a treatment strategy for multidrug resistance in childhood rhabdomyosarcoma. Int J Oncol. 2010;36(2):491–500.
CAS
PubMed
Google Scholar
Lewis AD, Forrester LM, Hayes JD, Wareing CJ, Carmichael J, Harris AL, et al. Glutathione S-transferase isoenzymes in human tumours and tumour derived cell lines. Br J Cancer. 1989;60(3):327–31.
Article
PubMed Central
CAS
PubMed
Google Scholar
Reed JC. Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance. Curr Opin Oncol. 1995;7(6):541–6.
Article
CAS
PubMed
Google Scholar
van Veen HW, Konings WN. The ABC family of multidrug transporters in microorganisms. Biochim Biophys Acta. 1998;1365(1–2):31–6.
Article
PubMed
Google Scholar
Wang B, Peng XX, Sun R, Li J, Zhan XR, Wu LJ, et al. Systematic review of beta-elemene injection as adjunctive treatment for lung cancer. Chin J Integr Med. 2012;18(11):813–23. doi:10.1007/s11655-012-1271-9.
Article
CAS
PubMed
Google Scholar
Roninson IB, Chin JE, Choi KG, Gros P, Housman DE, Fojo A, et al. Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. Proc Natl Acad Sci USA. 1986;83(12):4538–42.
Article
PubMed Central
CAS
PubMed
Google Scholar
Van der Bliek AM, Baas F, Ten Houte de Lange T, Kooiman PM, Van der Velde-Koerts T, Borst P. The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver. EMBO J. 1987;6(11):3325–31.
PubMed Central
CAS
PubMed
Google Scholar
de Bruijn MH, Van der Bliek AM, Biedler JL, Borst P. Differential amplification and disproportionate expression of five genes in three multidrug-resistant Chinese hamster lung cell lines. Mol Cell Biol. 1986;6(12):4717–22.
PubMed Central
PubMed
Google Scholar
Gros P, Raymond M, Bell J, Housman D. Cloning and characterization of a second member of the mouse mdr gene family. Mol Cell Biol. 1988;8(7):2770–8.
PubMed Central
CAS
PubMed
Google Scholar
Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, et al. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science. 1992;258(5088):1650–4.
Article
CAS
PubMed
Google Scholar
Guo Y, Kotova E, Chen ZS, Lee K, Hopper-Borge E, Belinsky MG, et al. MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2′,3′-dideoxycytidine and 9′-(2′-phosphonylmethoxyethyl)adenine. J Biol Chem. 2003;278(32):29509–14. doi:10.1074/jbc.M304059200.
Article
CAS
PubMed
Google Scholar
Robert J, Jarry C. Multidrug resistance reversal agents. J Med Chem. 2003;46(23):4805–17. doi:10.1021/jm030183a.
Article
CAS
PubMed
Google Scholar
Krishna R, Mayer LD. Liposomal doxorubicin circumvents PSC 833-free drug interactions, resulting in effective therapy of multidrug-resistant solid tumors. Cancer Res. 1997;57(23):5246–53.
CAS
PubMed
Google Scholar
Wu CP, Calcagno AM, Ambudkar SV. Reversal of ABC drug transporter-mediated multidrug resistance in cancer cells: evaluation of current strategies. Curr Mol Pharmacol. 2008;1(2):93–105.
Article
PubMed Central
CAS
PubMed
Google Scholar
Tsuruo T, Iida H, Tsukagoshi S, Sakurai Y. Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res. 1981;41(5):1967–72.
CAS
PubMed
Google Scholar
Ozols RF, Cunnion RE, Klecker RW Jr, Hamilton TC, Ostchega Y, Parrillo JE, et al. Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients. J Clin Oncol. 1987;5(4):641–7.
CAS
PubMed
Google Scholar
Dantzig AH, de Alwis DP, Burgess M. Considerations in the design and development of transport inhibitors as adjuncts to drug therapy. Adv Drug Deliv Rev. 2003;55(1):133–50.
Article
CAS
PubMed
Google Scholar
Tsuruo T, Iida H, Tsukagoshi S, Sakurai Y. Potentiation of vincristine and adriamycin effects in human hemopoietic tumor cell lines by calcium antagonists and calmodulin inhibitors. Cancer Res. 1983;43(5):2267–72.
CAS
PubMed
Google Scholar
Shukla S, Chen ZS, Ambudkar SV. Tyrosine kinase inhibitors as modulators of ABC transporter-mediated drug resistance. Drug Resist Updat. 2012;15(1–2):70–80. doi:10.1016/j.drup.2012.01.005.
Article
PubMed Central
CAS
PubMed
Google Scholar
Boesch D, Muller K, Pourtier-Manzanedo A, Loor F. Restoration of daunomycin retention in multidrug-resistant P388 cells by submicromolar concentrations of SDZ PSC 833, a nonimmunosuppressive cyclosporin derivative. Exp Cell Res. 1991;196(1):26–32.
Article
CAS
PubMed
Google Scholar
Germann UA, Shlyakhter D, Mason VS, Zelle RE, Duffy JP, Galullo V, et al. Cellular and biochemical characterization of VX-710 as a chemosensitizer: reversal of P-glycoprotein-mediated multidrug resistance in vitro. Anticancer Drugs. 1997;8(2):125–40.
Article
CAS
PubMed
Google Scholar
Filipski E, Berland E, Ozturk N, Guettier C, van der Horst GT, Levi F, et al. Optimization of irinotecan chronotherapy with P-glycoprotein inhibition. Toxicol Appl Pharmacol. 2014;274(3):471–9. doi:10.1016/j.taap.2013.12.018.
Article
CAS
PubMed
Google Scholar
Aouali N, El Btaouri H, Dumontet C, Eddabra L, Malagarie-Cazenave S, Madoulet C, et al. Accumulation of lactosylceramide and overexpression of a PSC833-resistant P-glycoprotein in multidrug-resistant human sarcoma cells. Oncol Rep. 2011;25(4):1161–7. doi:10.3892/or.2011.1180.
CAS
PubMed
Google Scholar
Lhomme C, Joly F, Walker JL, Lissoni AA, Nicoletto MO, Manikhas GM, et al. Phase III study of valspodar (PSC 833) combined with paclitaxel and carboplatin compared with paclitaxel and carboplatin alone in patients with stage IV or suboptimally debulked stage III epithelial ovarian cancer or primary peritoneal cancer. J Clin Oncol. 2008;26(16):2674–82. doi:10.1200/JCO.2007.14.9807.
Article
CAS
PubMed
Google Scholar
Muller H, Pajeva IK, Globisch C, Wiese M. Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. Bioorg Med Chem. 2008;16(5):2448–62. doi:10.1016/j.bmc.2007.11.057.
Article
PubMed
Google Scholar
Morschhauser F, Zinzani PL, Burgess M, Sloots L, Bouafia F, Dumontet C. Phase I/II trial of a P-glycoprotein inhibitor, Zosuquidar. 3HCl trihydrochloride (LY335979), given orally in combination with the CHOP regimen in patients with non-Hodgkin’s lymphoma. Leuk Lymphoma. 2007;48(4):708–15. doi:10.1080/10428190701190169.
Article
CAS
PubMed
Google Scholar
van Zuylen L, Sparreboom A, van der Gaast A, Nooter K, Eskens FA, Brouwer E, et al. Disposition of docetaxel in the presence of P-glycoprotein inhibition by intravenous administration of R101933. Eur J Cancer. 2002;38(8):1090–9.
Article
PubMed
Google Scholar
Guns ES, Bullock PL, Reimer ML, Dixon R, Bally M, Mayer LD. Assessment of the involvement of CYP3A in the vitro metabolism of a new modulator of MDR in cancer chemotherapy, OC144-193, by human liver microsomes. Eur J Drug Metab Pharmacokinet. 2001;26(4):273–82.
Article
CAS
PubMed
Google Scholar
Kim TE, Lee H, Lim KS, Lee S, Yoon SH, Park KM, et al. Effects of HM30181, a P-glycoprotein inhibitor, on the pharmacokinetics and pharmacodynamics of loperamide in healthy volunteers. Br J Clin Pharmacol. 2014;. doi:10.1111/bcp.12368.
Google Scholar
Karikas GA. Anticancer and chemopreventing natural products: some biochemical and therapeutic aspects. J BUON. 2010;15(4):627–38.
PubMed
Google Scholar
Guo H, Wang DS, Rizwani GH, Ahmed M, Ahmed M, Hassan A, et al. Antineoplastic activity of Holoptelea integrifolia (Roxb.) Planch bark extracts (in vitro). Pak J Pharm Sci. 2013;26(6):1151–6.
PubMed
Google Scholar
Guo HQ, Zhang GN, Wang YJ, Zhang YK, Sodani K, Talele TT, et al. beta-Elemene, a compound derived from Rhizoma zedoariae, reverses multidrug resistance mediated by the ABCB1 transporter. Oncol Rep. 2014;31(2):858–66. doi:10.3892/or.2013.2870.
CAS
PubMed
Google Scholar
Lu JJ, Dang YY, Huang M, Xu WS, Chen XP, Wang YT. Anticancer properties of terpenoids isolated from Rhizoma Curcumae—a review. J Ethnopharmacol. 2012;143(2):406–11. doi:10.1016/j.jep.2012.07.009.
Article
CAS
PubMed
Google Scholar
Liu J, Zhang Y, Qu J, Xu L, Hou K, Zhang J, et al. beta-Elemene-induced autophagy protects human gastric cancer cells from undergoing apoptosis. BMC Cancer. 2011;11:183. doi:10.1186/1471-2407-11-183.
Article
PubMed Central
CAS
PubMed
Google Scholar
Yao YQ, Xu YH, Lu J, Zhou HY, Wang YZ. Effect of p38 MAPK on elemene-induced cell cycle arrest in C6 glioblastoma cells. Zhonghua Yi Xue Za Zhi. 2008;88(1):56–8 (in Chinese).
CAS
PubMed
Google Scholar
Brown JM, Attardi LD. The role of apoptosis in cancer development and treatment response. Nat Rev Cancer. 2005;5(3):231–7. doi:10.1038/nrc1560.
CAS
PubMed
Google Scholar
Guo B, Zhai D, Cabezas E, Welsh K, Nouraini S, Satterthwait AC, et al. Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature. 2003;423(6938):456–61. doi:10.1038/nature01627.
Article
CAS
PubMed
Google Scholar
Chaudhry P, Srinivasan R, Patel FD. Differential expression of Fas family members and Bcl-2 family members in benign versus malignant epithelial ovarian cancer (EOC) in North Indian population. Mol Cell Biochem. 2012;368(1–2):119–26. doi:10.1007/s11010-012-1350-7.
Article
CAS
PubMed
Google Scholar
Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene. 1994;9(6):1799–805.
CAS
PubMed
Google Scholar
Chen X, Wang Y, Luo H, Luo Z, Zhang T, Yang N, et al. beta-Elemene acts as an antitumor factor and downregulates the expression of survivin, Bcl-xL and Mta-1. Mol Med Rep. 2012;6(5):989–95. doi:10.3892/mmr.2012.1018.
CAS
PubMed
Google Scholar
Li QQ, Wang G, Huang F, Banda M, Reed E. Antineoplastic effect of beta-elemene on prostate cancer cells and other types of solid tumour cells. J Pharm Pharmacol. 2010;62(8):1018–27. doi:10.1111/j.2042-7158.2010.01135.x.
Article
CAS
PubMed
Google Scholar
Zhao S, Wu J, Zheng F, Tang Q, Yang L, Li L, et al. beta-Elemene inhibited expression of DNA methyltransferase 1 through activation of ERK1/2 and AMPKalpha signalling pathways in human lung cancer cells: the role of Sp1. J Cell Mol Med. 2015;19(3):630–41. doi:10.1111/jcmm.12476.
Article
PubMed Central
CAS
PubMed
Google Scholar
Li G, Xie B, Li X, Chen Y, Xu Y, Xu-Welliver M, et al. Downregulation of peroxiredoxin-1 by beta-elemene enhances the radiosensitivity of lung adenocarcinoma xenografts. Oncol Rep. 2015;33(3):1427–33. doi:10.3892/or.2015.3732.
PubMed
Google Scholar
Xu HB, Li L, Fu J, Mao XP, Xu LZ. Reversion of multidrug resistance in a chemoresistant human breast cancer cell line by beta-elemene. Pharmacology. 2012;89(5–6):303–12. doi:10.1159/000337178.
Article
CAS
PubMed
Google Scholar
Gottlieb E, Armour SM, Harris MH, Thompson CB. Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis. Cell Death Differ. 2003;10(6):709–17. doi:10.1038/sj.cdd.4401231.
Article
CAS
PubMed
Google Scholar
Lowe SW, Ruley HE, Jacks T, Housman DE. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell. 1993;74(6):957–67.
Article
CAS
PubMed
Google Scholar
Sui X, Kong N, Ye L, Han W, Zhou J, Zhang Q, et al. p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents. Cancer Lett. 2014;344(2):174–9. doi:10.1016/j.canlet.2013.11.019.
Article
CAS
PubMed
Google Scholar
Elias J, Dimitrio L, Clairambault J, Natalini R. The p53 protein and its molecular network: modelling a missing link between DNA damage and cell fate. Biochim Biophys Acta. 2014;1844(1 Pt B):232–47. doi:10.1016/j.bbapap.2013.09.019.
Article
CAS
PubMed
Google Scholar
Saha MN, Qiu L, Chang H. Targeting p53 by small molecules in hematological malignancies. J Hematol Oncol. 2013;6:23. doi:10.1186/1756-8722-6-23.
Article
PubMed Central
CAS
PubMed
Google Scholar
Wang JQ, Du ZW, Gao XF, Wu M, Zhang YC, Pan Y, et al. The effect of Bcl-2 gene silencing on the sensitivity of cell line A549 to chemotherapeutic drugs. Zhonghua Jie He He Hu Xi Za Zhi. 2013;36(3):191–7 (in Chinese).
PubMed
Google Scholar
Hu J, Jin W, Yang PM. Reversal of resistance to adriamycin in human breast cancer cell line MCF-7/ADM by beta-elemene. Zhonghua Zhong Liu Za Zhi. 2004;26(5):268–70 (in Chinese).
CAS
PubMed
Google Scholar
Li QQ, Lee RX, Liang H, Wang G, Li JM, Zhong Y, et al. beta-Elemene enhances susceptibility to cisplatin in resistant ovarian carcinoma cells via downregulation of ERCC-1 and XIAP and inactivation of JNK. Int J Oncol. 2013;43(3):721–8. doi:10.3892/ijo.2013.1996.
PubMed Central
CAS
PubMed
Google Scholar
Li QQ, Wang G, Liang H, Li JM, Huang F, Agarwal PK, et al. beta-Elemene promotes cisplatin-induced cell death in human bladder cancer and other carcinomas. Anticancer Res. 2013;33(4):1421–8.
CAS
PubMed
Google Scholar
Li QQ, Wang G, Huang F, Li JM, Cuff CF, Reed E. Sensitization of lung cancer cells to cisplatin by beta-elemene is mediated through blockade of cell cycle progression: antitumor efficacies of beta-elemene and its synthetic analogs. Med Oncol. 2013;30(1):488. doi:10.1007/s12032-013-0488-9.
Article
CAS
PubMed
Google Scholar
Ward A, Shukla K, Balwierz A, Soons Z, Konig R, Sahin O, et al. microRNA-519a is a novel oncomir conferring tamoxifen resistance by targeting a network of tumor-suppressor genes in ER+ breast cancer. J Pathol. 2014;. doi:10.1002/path.4363.
Google Scholar
Zhang B, Zhang X, Tang B, Zheng P, Zhang Y. Investigation of elemene-induced reversal of tamoxifen resistance in MCF-7 cells through oestrogen receptor alpha (ERalpha) re-expression. Breast Cancer Res Treat. 2012;136(2):399–406. doi:10.1007/s10549-012-2263-6.
Article
CAS
PubMed
Google Scholar
Wang Z, Xia Q, Cui J, Diao Y, Li J. Reversion of P-glycoprotein-mediated multidrug resistance by diallyl trisulfide in a human osteosarcoma cell line. Oncol Rep. 2014;31(6):2720–6. doi:10.3892/or.2014.3154.
CAS
PubMed
Google Scholar
Fu TH, Li JY, Jing YY, Sun PJ, Bai X. Effect of elemene on reversing chemoresistance to adriamycin in human stomach cancer cell line. Zhong Yao Cai. 2013;36(4):601–3 (in Chinese).
CAS
PubMed
Google Scholar
Zhu TZ, Li XM, Luo LH, Song ZQ, Gao X, Li ZQ, et al. beta-Elemene inhibits stemness, promotes differentiation and impairs chemoresistance to temozolomide in glioblastoma stem-like cells. Int J Oncol. 2014;45(2):699–709. doi:10.3892/ijo.2014.2448.
PubMed
Google Scholar
Zhu TZ, Li XM, Luo LH, Xu YH, Cao P, Liu Y, et al. beta-Elemene inhibits proliferation through crosstalk between glia maturation factor beta and extracellular signalregulated kinase 1/2 and impairs drug resistance to temozolomide in glioblastoma cells. Mol Med Rep. 2014;10(2):1122–8. doi:10.3892/mmr.2014.2273.
CAS
PubMed
Google Scholar
Cai DY, Gao X, Wu XH, Hong TT. Synergistic effect of beta-elemene injection combined paclitaxel injection on human breast cancer MB-468 cells: an in vitro study. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013;33(7):978–82 (in Chinese).
CAS
PubMed
Google Scholar
Zhang F, Xu L, Qu X, Zhao M, Jin B, Kang J, et al. Synergistic antitumor effect of beta-elemene and etoposide is mediated via induction of cell apoptosis and cell cycle arrest in non-small cell lung carcinoma cells. Mol Med Rep. 2011;4(6):1189–93. doi:10.3892/mmr.2011.537.
CAS
PubMed
Google Scholar