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  1. Metastatic melanoma has long been considered to have a very poor prognosis and to be chemo-resistant. However, a subgroup of patients with metastatic melanoma presents remarkable responses to chemotherapeutic ...

    Authors: Aurélien Simon, Hampig Raphael Kourie and Joseph Kerger

    Citation: Chinese Journal of Cancer 2017 36:10

    Content type: Case report

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  2. Concurrent chemoradiotherapy (CCRT) significantly increases the survival rate of esophageal squamous cell carcinoma (ESCC) patients with malignant fistulae. Recent clinical evidence has shown the benefits of e...

    Authors: Li Ma, Guang-Yu Luo, Yu-Feng Ren, Bo Qiu, Hong Yang, Chun-Xia Xie, Song-Ran Liu, Shi-Liang Liu, Zhao-Lin Chen, Qun Li, Jian-Hua Fu, Meng-Zhong Liu, Yong-Hong Hu, Wen-Feng Ye and Hui Liu

    Citation: Chinese Journal of Cancer 2017 36:8

    Content type: Original article

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  3. Body mass index (BMI) has a U-shaped association with lung cancer risk. However, the effect of BMI on prognosis is controversial. This retrospective study aimed to investigate the effect of BMI on the survival...

    Authors: Hao-Jun Xie, Xu Zhang, Zhen-Qiang Wei, Hao Long, Tie-Hua Rong and Xiao-Dong Su

    Citation: Chinese Journal of Cancer 2017 36:7

    Content type: Original article

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  4. Chemotherapy-induced nausea and vomiting adversely affects the quality of life of patients who receive chemotherapy via intravenous infusion or transcatheter arterial chemoembolization (TACE). This study aimed...

    Authors: Jing Xie, Lei-Hua Chen, Zhou-Yu Ning, Chen-Yue Zhang, Hao Chen, Zhen Chen, Zhi-Qiang Meng and Xiao-Yan Zhu

    Citation: Chinese Journal of Cancer 2017 36:6

    Content type: Original article

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  5. Ras protein signaling pathways are important in controlling the plight of different types of cancer. Here we discussed the paper entitled “Small molecule stabilization of the KSR inactive state antagonizes onc...

    Authors: Syed Lal Badshah and Yahia Mabkhot

    Citation: Chinese Journal of Cancer 2017 36:5

    Content type: Editorial

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  6. Birt–Hogg–Dubé (BHD) syndrome, a hereditary renal cancer syndrome caused by mutations in the folliculin (FLCN) gene, is characterized by the presence of fibrofolliculomas, pulmonary cysts, spontaneous pneumothora...

    Authors: Teng Li, Xianghui Ning, Qun He and Kan Gong

    Citation: Chinese Journal of Cancer 2017 36:4

    Content type: Case report

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  7. Nasopharyngeal carcinoma (NPC) is a commonly diagnosed cancer in Southeast Asia. Many studies have examined the risk factors for NPC, yet the roles of some risk factors remain inconclusive. The purpose of this...

    Authors: Sook Kwin Yong, Tam Cam Ha, Ming Chert Richard Yeo, Valerie Gaborieau, James D. McKay and Joseph Wee

    Citation: Chinese Journal of Cancer 2017 36:3

    Content type: Original article

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  8. A ruptured hepatocellular carcinoma (HCC) is often fatal. In addition to surgery and transarterial embolization, radiofrequency ablation (RFA) might be another option for treating a ruptured HCC. Unfortunately...

    Authors: Jin-Hua Huang, John N. Morelli, Fei Ai, Ru-Hai Zou, Yang-Kui Gu, Fei Gao, Tian-Qi Zhang, Wang Yao, Xiong-Ying Jiang and Yan-Yang Zhang

    Citation: Chinese Journal of Cancer 2017 36:1

    Content type: Case report

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  9. The prognostic values of staging parameters require continual re-assessment amid changes in diagnostic and therapeutic methods. This study aimed to identify the prognostic factors and failure patterns of non-m...

    Authors: Yan-Ping Mao, Ling-Long Tang, Lei Chen, Ying Sun, Zhen-Yu Qi, Guan-Qun Zhou, Li-Zhi Liu, Li Li, Ai-Hua Lin and Jun Ma

    Citation: Chinese Journal of Cancer 2016 35:103

    Content type: Original article

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  10. Capecitabine and irinotecan combination therapy (XELIRI) has been examined at various dose levels to treat metastatic colorectal cancer (mCRC). Recently, in the Association of Medical Oncology of the German Ca...

    Authors: Masahito Kotaka, Ruihua Xu, Kei Muro, Young Suk Park, Satoshi Morita, Satoru Iwasa, Hiroyuki Uetake, Tomohiro Nishina, Hiroaki Nozawa, Hiroshi Matsumoto, Kentaro Yamazaki, Sae-Won Han, Wei Wang, Joong Bae Ahn, Yanhong Deng, Sang-Hee Cho…

    Citation: Chinese Journal of Cancer 2016 35:102

    Content type: Study Protocol

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  11. After definitive chemoradiotherapy for non-metastatic nasopharyngeal carcinoma (NPC), more than 10% of patients will experience a local recurrence. Salvage treatments present significant challenges for locally...

    Authors: Lin Kong, Jing Gao, Jiyi Hu, Weixu Hu, Xiyin Guan, Rong Lu and Jiade J. Lu

    Citation: Chinese Journal of Cancer 2016 35:101

    Content type: Study Protocol

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  12. The TNM staging system is far from perfect in predicting the survival of individual cancer patients because only the gross anatomy is considered. The survival rates of the patients who have the same TNM stage ...

    Authors: Wenhua Liang, Guanzhu Shen, Yaxiong Zhang, Gang Chen, Xuan Wu, Yang Li, Anchuan Li, Shiyang Kang, Xi Yuan, Xue Hou, Peiyu Huang, Yan Huang, Hongyun Zhao, Ying Tian, Chong Zhao and Li Zhang

    Citation: Chinese Journal of Cancer 2016 35:98

    Content type: Original article

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  13. Gross target volume of primary tumor (GTV-P) is very important for the prognosis prediction of patients with nasopharyngeal carcinoma (NPC), but it is unknown whether the same is true for locally advanced NPC ...

    Authors: Yu-Xiang He, Ying Wang, Peng-Fei Cao, Lin Shen, Ya-Jie Zhao, Zi-Jian Zhang, Deng-Ming Chen, Tu-Bao Yang, Xin-Qiong Huang, Zhou Qin, You-Yi Dai and Liang-Fang Shen

    Citation: Chinese Journal of Cancer 2016 35:96

    Content type: Original article

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  14. Programmed cell death protein 4 (PDCD4) is a novel tumor suppressor protein involved in programmed cell death. Its association with cancer progression has been observed in multiple tumor models, but evidence s...

    Authors: John Zeng Hong Li, Wei Gao, Wai-Kuen Ho, Wen Bin Lei, William Ignace Wei, Jimmy Yu-Wai Chan and Thian-Sze Wong

    Citation: Chinese Journal of Cancer 2016 35:95

    Content type: Original article

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  15. Posterior fossa ependymoma comprises two distinct molecular entities, ependymoma_posterior fossa A (EPN_PFA) and ependymoma_posterior fossa B (EPN_PFB), with differentiable gene expression profiles. As yet, th...

    Authors: Vijay Ramaswamy and Michael D. Taylor

    Citation: Chinese Journal of Cancer 2016 35:93

    Content type: Research highlight

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  16. Many biologic products have improved the outcomes of cancer patients, but the costs can substantially burden healthcare systems. Biosimilar products can potentially reduce drug costs and increase patient acces...

    Authors: Linda K. S. Leung, Kevin Mok, Calvin Liu and Stephen L. Chan

    Citation: Chinese Journal of Cancer 2016 35:91

    Content type: Review

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  17. The increasing incidence of radiation-induced osteosarcoma of the maxilla and mandible (RIOSM) has become a significant problem that can limit long-term survival. The purpose of this study was to analyze the a...

    Authors: Lie-Qiang Liao, Hong-Hong Yan, Jun-Hao Mai, Wei-Wei Liu, Hao Li, Zhu-Ming Guo, Zong-Yuan Zeng and Xue-Kui Liu

    Citation: Chinese Journal of Cancer 2016 35:89

    Content type: Original article

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  18. In patients with diffuse large B-cell lymphoma (DLBCL), central nervous system (CNS) relapse is uncommon but is nearly always fatal. This study aimed to determine the risk factors for CNS relapse in DLBCL pati...

    Authors: Qing-Qing Cai, Li-Yang Hu, Qi-Rong Geng, Jie Chen, Zhen-Hai Lu, Hui-Lan Rao, Qing Liu, Wen-Qi Jiang, Hui-Qiang Huang, Tong-Yu Lin and Zhong-Jun Xia

    Citation: Chinese Journal of Cancer 2016 35:87

    Content type: Original article

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  19. Despite the recent development of new therapies, multiple myeloma (MM) remains an incurable disease. Thus, new, effective treatments are urgently needed, particularly for relapsed or refractory MM (RRMM). In a...

    Authors: Yun Leng, Lugui Qiu, Jian Hou, Yaozhong Zhao, Xuejun Zhang, Shifang Yang, Hao Xi, Zhongxia Huang, Ling Pan and Wenming Chen

    Citation: Chinese Journal of Cancer 2016 35:86

    Content type: Original article

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  20. Platinum-based chemotherapy is the first-line treatment of non-small cell lung cancer (NSCLC); it is therefore important to discover biomarkers that can be used to predict the efficacy and toxicity of this tre...

    Authors: Chen-Yue Qian, Yi Zheng, Ying Wang, Juan Chen, Jun-Yan Liu, Hong-Hao Zhou, Ji-Ye Yin and Zhao-Qian Liu

    Citation: Chinese Journal of Cancer 2016 35:85

    Content type: Original article

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  21. Gastric cancer ranks the fourth most prevalent malignancy yet it is the second leading cause of cancer-related death. Every year, gastric cancer adds nearly 1 million new cancer cases, and 723,000 or 10% of ca...

    Authors: Li Yan

    Citation: Chinese Journal of Cancer 2016 35:84

    Content type: Editorial

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  22. Gastric (including gastroesophageal junction) cancer is the third leading cause of cancer-related death in the world. In China, an estimated 420,000 patients were diagnosed with gastric cancer in 2011, ranking...

    Authors: Weijing Sun and Li Yan

    Citation: Chinese Journal of Cancer 2016 35:83

    Content type: Review

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  23. Combined hepatocellular and cholangiocarcinoma (CHC) is a unique subtype of liver cancer comprising both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC); however, its cellular origin r...

    Authors: Qian Zhao, Wen-Long Yu, Xin-Yuan Lu, Hui Dong, Yi-Jin Gu, Xia Sheng, Wen-Ming Cong and Meng-Chao Wu

    Citation: Chinese Journal of Cancer 2016 35:82

    Content type: Original article

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  24. Small hepatocellular carcinoma (sHCC) is a unique variant of HCC that is characterized by small tumor size (maximum tumor diameter ≤3 cm) and favorable long-term outcomes. The present study aimed to define cli...

    Authors: Mu-Yan Cai, Feng-Wei Wang, Chang-Peng Li, Li-Xu Yan, Jie-Wei Chen, Rong-Zhen Luo, Jing-Ping Yun, Yi-Xin Zeng and Dan Xie

    Citation: Chinese Journal of Cancer 2016 35:80

    Content type: Original article

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  25. Von Hippel–Lindau (VHL) syndrome is a dominantly inherited multisystem cancer syndrome caused by a heterozygous mutation in the VHL tumor suppressor gene. Previous studies suggested that similar populations of Ca...

    Authors: Meihua Wong, Ying-Hsia Chu, Hwei Ling Tan, Hideharu Bessho, Joanne Ngeow, Tiffany Tang and Min-Han Tan

    Citation: Chinese Journal of Cancer 2016 35:79

    Content type: Original article

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  26. Serum immunoglobulin A antibodies against Epstein–Barr virus (EBV), viral capsid antigen (VCA-IgA) and early antigen (EA-IgA), are used to screen for nasopharyngeal carcinoma (NPC) in endemic areas. However, t...

    Authors: Jin-Lin Du, Sui-Hong Chen, Qi-Hong Huang, Shang-Hang Xie, Yan-Fang Ye, Rui Gao, Jie Guo, Meng-Jie Yang, Qing Liu, Ming-Huang Hong and Su-Mei Cao

    Citation: Chinese Journal of Cancer 2016 35:78

    Content type: Original article

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  27. MicroRNA (miRNA) polymorphisms may alter miRNA-related processes, and they likely contribute to cancer susceptibility. Various studies have investigated the associations between genetic variants in several key...

    Authors: Limin Miao, Lihua Wang, Longbiao Zhu, Jiangbo Du, Xun Zhu, Yuming Niu, Ruixia Wang, Zhibin Hu, Ning Chen, Hongbing Shen and Hongxia Ma

    Citation: Chinese Journal of Cancer 2016 35:77

    Content type: Original article

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  28. Esophageal squamous cell carcinoma (ESCC) is a leading cause of cancer death worldwide and is characterized by numerous genetic mutations. TNM staging is not sufficient for predicting patient outcomes. Additio...

    Authors: Yuan-Bin Chen and Wei-Hua Jia

    Citation: Chinese Journal of Cancer 2016 35:76

    Content type: Research highlight

    Published on:

  29. Although the prognostic impact of body mass index (BMI) in patients with non-metastatic nasopharyngeal carcinoma (NPC) had been extensively studied, its effect among metastatic NPC patients remains unknown. Th...

    Authors: Wang Li, Lu-Jun Shen, Tao Chen, Xu-Qi Sun, Ying Zhang, Ming Wu, Wan-Hong Shu, Chen Chen, Chang-Chuan Pan, Yun-Fei Xia and Pei-Hong Wu

    Citation: Chinese Journal of Cancer 2016 35:75

    Content type: Original article

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  30. Clinical trials continue to be the gold standard for determining the efficacy of novel cancer treatments, but they may also expose participants to the potential risks of unpredictable or severe toxicities. The...

    Authors: Kiara Hugh-Yeun and Winson Y. Cheung

    Citation: Chinese Journal of Cancer 2016 35:74

    Content type: Research highlight

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  31. The National Central Cancer Registry (NCCR) collected population-based cancer registration data in 2012 from local registries and estimated the cancer incidence and mortality in China.

    Authors: Wanqing Chen, Rongshou Zheng, Hongmei Zeng and Siwei Zhang

    Citation: Chinese Journal of Cancer 2016 35:73

    Content type: Short report

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  32. Cancer metabolism and epigenetic alteration are two critical mechanisms for tumorigenesis and cancer progression; however, the dynamic interplay between them remains poorly understood. As reported in the artic...

    Authors: Shuang Liu and Yong-Guang Tao

    Citation: Chinese Journal of Cancer 2016 35:72

    Content type: Research highlight

    Published on:

    The Erratum to this article has been published in Chinese Journal of Cancer 2016 35:99

  33. The molecular prognostic markers and carcinogenesis of intrahepatic cholangiocarcinoma (ICC) have not been well documented. The purpose of this study was to investigate the prognostic value of the eyes absent ...

    Authors: Xiao-Yi Hao, Jian-Peng Cai, Xin Liu, Wei Chen, Xun Hou, Dong Chen, Jia-ming Lai, Li-Jian Liang and Xiao-Yu Yin

    Citation: Chinese Journal of Cancer 2016 35:70

    Content type: Original article

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  34. Surgical management of gastric cancer improves survival. However, for some time, surgeons have had diverse opinions about the extent of gastrectomy. Researchers have conducted many clinical studies, making slo...

    Authors: Hironori Shiozaki, Yusuke Shimodaira, Elena Elimova, Roopma Wadhwa, Kazuki Sudo, Kazuto Harada, Jeannelyn S. Estrella, Prajnan Das, Brian Badgwell and Jaffer A. Ajani

    Citation: Chinese Journal of Cancer 2016 35:69

    Content type: Review

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  35. Gastrointestinal stromal tumors (GISTs) have been recognized as a biologically distinctive type of tumor, different from smooth muscle and neural tumors of the gastrointestinal tract. The identification of gen...

    Authors: Weixin Yan, Aiguo Zhang and Michael J. Powell

    Citation: Chinese Journal of Cancer 2016 35:68

    Content type: Review

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  36. In the past decade, many researchers focused on to robot-assisted surgery. However, on long-term outcomes for patients with early-stage non–small cell lung cancer (NSCLC), whether the robotic procedure is supe...

    Authors: Hao-Xian Yang

    Citation: Chinese Journal of Cancer 2016 35:66

    Content type: Research highlight

    Published on:

  37. Complete resection of locally advanced sigmoid colon cancer (LASCC) is sometimes difficult. Patients with LASCC have a dismal prognosis and poor quality of life, which has encouraged the evaluation of alternat...

    Authors: Bo Qiu, Pei-Rong Ding, Ling Cai, Wei-Wei Xiao, Zhi-Fan Zeng, Gong Chen, Zhen-Hai Lu, Li-Ren Li, Xiao-Jun Wu, Rene-Olivier Mirimanoff, Zhi-Zhong Pan, Rui-Hua Xu and Yuan-Hong Gao

    Citation: Chinese Journal of Cancer 2016 35:65

    Content type: Original Article

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  38. MicroRNA-506 (miR-506) has been reported to function in several tumors as a tumor suppressor gene or oncogene. However, the expression and role of miR-506 in pancreatic ductal adenocarcinoma (PDAC) remains unc...

    Authors: Run-Fen Cheng, Jian Wang, Jing-Yi Zhang, Lin Sun, Yan-Rui Zhao, Zhi-Qiang Qiu, Bao-Cun Sun and Yan Sun

    Citation: Chinese Journal of Cancer 2016 35:64

    Content type: Original article

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