Skip to main content
Download PDF

Spontaneous regression of mantle cell lymphoma: a report of four cases

Cancer Communications volume 38, Article number: 30 (2018) Cite this article

Abstract

Background

Spontaneous regression has been reported in some indolent forms of lymphoma. Mantle cell lymphoma (MCL) is an aggressive lymphoid neoplasm and has a poor prognosis. However, approximately 30% of MCL patients can exhibit indolent clinical behavior. To date, complete spontaneous regression of MCL has not been reported.

Case presentation

We describe four cases of spontaneous regression of MCL. At the time of presentation, these patients were asymptomatic, with lymph node enlargement and mild to moderate fluorodeoxyglucose (FDG) uptake on FDG-positron emission tomography combined with computed tomography. One of the possible mechanisms of spontaneous regression of the tumor could be due to the host immune response through humoral and cellular immunity, which may have a role in the clearance of tumor cells.

Conclusions

In this report, we support the use of a “wait and watch” strategy for MCL patients with no risk factors and indolent behavior. This strategy helps spare patients from further potentially harmful chemotherapy. In addition, we describe the phenomenon of spontaneous regression in MCL patients who are asymptomatic and have low-volume disease.

Background

Patients with various neoplastic diseases have experienced spontaneous regression (SR), including 10%–20% of patients with indolent lymphoma [1]. Compared with SR rates in indolent lymphoma, SR rates in aggressive lymphomas are relatively low [2]. Typically, mantle cell lymphoma (MCL) is an aggressive lymphoid neoplasm and has a poor prognosis. However, approximately 30% of MCL patients exhibit indolent clinical behavior [3].

Despite the indolent clinical behavior in some MCL cases, complete SR of MCL has not been reported, and partial SR of MCL has been reported only once to date. In that report, Kumar et al. [4] described a case of MCL, monitored by serial fluorodeoxyglucose (FDG)-positron emission tomography combined with computed tomography (PET/CT), in which a significant spontaneous reduction in FDG uptake was observed, suggestive of partial regression. Here, we describe four cases of SR of MCL that were observed after a “wait and watch” treatment strategy.

Case presentation

Case 1

A 48-year-old man was diagnosed with MCL in July 2010 from an excisional biopsy of the right inguinal lymph node. The pathology was reported as classic MCL, with a Ki-67 value of 10%–15%. Bone marrow biopsy revealed less than 5% involvement, and marrow aspirate flow cytometry showed a small population of phenotypically aberrant CD5-positive B cells monotypic for lambda light chain. At the time of presentation, the patient’s mantle cell international prognostic index (MIPI) score was 2 (one point for serum lactate dehydrogenase and one point for white blood cell count).

The patient was initially treated with serial monitoring; however, 3 months later, he developed progressive disease and was enrolled in a clinical trial with rituximab, cladribine, and vorinostat, receiving six cycles of chemotherapy between September 2010 and February 2011. He achieved complete remission and received maintenance therapy with rituximab every 2 months between March 2011 and August 2011. However, a left inguinal lymph node grew shortly thereafter in September 2011, and recurrence of MCL was confirmed by core needle biopsy. The pathology report at the time described a diffuse lymphoid infiltrate of non-blastoid cytology composed of small- to medium-sized lymphoid cells that were cyclin D1-positive. Bone marrow and CT examination were otherwise negative for lymphoma. The patient has since been observed without therapy, and his residual adenopathy spontaneously regressed after the first follow-up examination. The most recent PET/CT performed in November 2016 still showed no evidence of lymphoma (Fig. 1a).

Fig. 1
figure1

Spontaneous regression of four cases of mantle cell lymphoma. a Comparison of positron emission tomography combined with computed tomography (PET/CT) images on September 15, 2011, September 19, 2012, and November 3, 2016, showing the resolution of fluorodeoxyglucose (FDG)-avid lymph nodes in a 48-year-old man with MCL (case 1). b Comparison of PET/CT on November 11, 2015, and January 14, 2016, showing the resolution of FDG uptake in the right axillary, prevascular, left obturator, and bilateral inguinal lymph nodes in a 44-year-old woman with MCL (case 2). c Chest CT with contrast on April 2014 showed right axillary lymph node enlargement (1.3 × 1.1 cm), whereas chest CT on July 2014 showed a decrease in size (0.8 × 1.0 cm) in a 63-year-old man with MCL (case 3). d PET/CT on September 2011 showed low-grade FDG-avid inguinal and left posterior cervical triangle adenopathy (Standardized uptake value was 2.6), whereas PET/CT on June 2015 showed resolution in a 68-year-old man with MCL (case 4). Red arrows indicate FDG-avid lymph nodes

Full size image

Case 2

A 44-year-old woman with left groin pain for 3–4 weeks in August 2015 underwent CT scans of the abdomen and pelvis, which revealed bilateral inguinal as well as pelvic lymphadenopathy. An ultrasound of the inguinal lymph nodes demonstrated multiple enlarged hypoechoic lymph nodes, the largest measuring 2.7 × 1.3 cm on the left side and 3.3 × 2.4 cm on the right side. A left inguinal lymph node ultrasound-guided needle core biopsy showed MCL with nodular and diffuse patterns and a Ki-67 value of 10%. Fluorescence in situ hybridization (FISH) assays were positive for the translocation between the CCND1 gene located on 11q13 and the IGH gene located on 14q32 (CCND1/IGH) (90% of cells). Later, PET/CT showed mild to moderate FDG uptake in multiple nodal areas including the inguinal, left external iliac chain, and bilateral axillary lymph nodes, with a maximum standardized uptake value (SUV) of 1.3–2.9 (Fig. 1b). Furthermore, there was involvement of the bone marrow with 5% of total bone marrow cellularity.

In October 2015, the patient was referred to MD Anderson Cancer Center, where physical examination revealed palpable bilateral inguinal lymph nodes measuring 1–3 cm. She was asymptomatic with low-volume disease (Table 1) and underwent an observational treatment strategy. A PET/CT in January 2016 showed a decrease in tumor size and uptake of FDG-avid disease (Fig. 1b), suggesting partial SR. In May 2016 and January 2017, repeated PET/CT scans showed stable disease.

Table 1 Characteristics of four cases of spontaneous regression of mantle cell lymphoma (MCL)
Full size table

Case 3

A 63-year-old man was diagnosed with MCL in October 2009. The initial pathology was reported as a diffuse pattern with a Ki-67 value of 10%–15% and 5% marrow involvement. He was initially treated with rituximab and hyper-CVAD (fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone) alternated with rituximab, methotrexate, and cytarabine. In total, the patient received six cycles (three of each) of therapy, which were completed in December 2010, and he achieved complete remission, which lasted for 4 years; in April 2014, however, his disease relapsed in the right axillary lymph node, as evidenced by lymph node biopsy (Fig. 1c). At that time, CT scans with contrast of the neck/abdomen/pelvis and bilateral bone marrow biopsies were all negative for the presence of disease. The patient was then observed without therapy, and 3 months later, chest CT with contrast showed a spontaneous decrease in the size of the lymph node (Fig. 1c). Serial monitoring with CT scans showed no change, and PET/CT scans between October 2016 and April 2017 showed no suspicious activity and spontaneous regression of the existing disease.

Case 4

A 68-year-old man underwent incidental removal of enlarged right inguinal lymph nodes at the time of surgery for iliac artery aneurysm in January 2011. The pathology was reported as MCL with a mantle zone pattern and with a Ki-67 value of approximately 5%. At that time, the patient was asymptomatic and had no other evidence of lymphoma on CT with contrast of the chest, abdomen, and pelvis. It was decided that he would undergo watchful waiting and serial monitoring of the disease.

In September 2011, a surveillance cervical CT scan with contrast showed sub-centimeter lymph nodes at the left posterior cervical triangle, and PET/CT showed low-grade FDG-avidity at these nodes (Fig. 1d), with an SUV of 2.6 in the left posterior cervical triangle and minimal FDG activity in the bilateral inguinal lymph nodes. Further evaluation at the time included bilateral bone marrow biopsy and upper and lower endoscopic biopsies, both of which showed no evidence of lymphoma.

In June 2015, a follow-up PET/CT showed that the FDG-avid area had regressed spontaneously (Fig. 1d). On the last follow-up in July 2016, the patient showed no signs of MCL.

All four patients denied having had any infections or using steroids during follow-up.

Discussion

Of the four cases that we describe herein, the regressed lesions of case 1 (relapsed), case 3 (relapsed), and case 2 were confirmed by pathological analysis to be MCL. Although the cervical lesion in case 4 was not confirmed pathologically, we believe that these regressed lymph nodes were highly suspicious for MCL. None of the four patients had a history of ongoing infection, antibiotic use or corticosteroid therapy use for any other diagnosis, any of which could have contributed to disease regression. In addition, no vaccination against any organism was given during the follow-up before regression.

All of the cases presented with good prognostic factors, including low Ki-67 values, low MIPI scores, and non-blastoid cytology. Tumor proliferation is recognized as a strong biological prognostic factor for MCL. Hoster et al. [5] reported differences in time-to-treatment failure and overall survival (OS) between groups with a Ki-67 value of < 30% and ≥ 30% among 543 patients studied. Furthermore, the modified combination of the Ki-67 index and MIPI (MIPI-c) separated 508 patients into four groups with 5-year OS rates of 85, 72, 43, and 17% (P < 0.001), and this combination of parameters was more discriminative than MIPI alone [6]. Our cases had a very low simplified MIPI with a Ki-67 value of < 30% (Table 1). In addition, the low SUV in PET/CT has been associated with an indolent clinical process: comparisons between SUVmax > 5 and < 5 in MCL patients have shown that the former group has decreased OS and failure-free survival [7]. Except for case 1, who presented with an SUV > 5 on PET/CT, all cases had an SUV of < 5 on PET/CT.

SR has been frequently reported in indolent lymphomas, including mucosa-associated lymphoid tissue lymphoma [8,9,10,11] and low-grade follicular lymphoma [12]. Compared with indolent lymphoma, aggressive non-Hodgkin lymphoma has a relatively low rate of SR [2]. In addition to non-Hodgkin lymphoma, SR has also been reported in classic Hodgkin lymphoma [13]. However, no case of complete SR has been reported in MCL, and only one case of MCL monitored by serial FDG-PET has been reported, which exhibited a significant but partial reduction in FDG uptake on serial whole-body PET scans, suggesting partial regression [4].

As shown in Table 1, the characteristics of the four cases demonstrated indolent behavior and low risk of progression. Interestingly, case 1 progressed after a brief follow-up and required therapy, which is not expected in indolent lymphomas; however, it was later determined that the recurrence had regressed spontaneously.

Possible mechanisms of SR reported in B cell neoplasms include an augmented host immune response through humoral and cellular immunity [2, 14]. For instance, post-allogeneic transplant lymphoproliferative disorders, usually of the aggressive large-cell lymphoma subtype, can be controlled by reducing and/or stopping the immunosuppressing agents [15]. Furthermore, the addition of the immune stimulator interferon-alpha to a doxorubicin-containing regimen for patients with advanced-stage and clinically aggressive follicular lymphomas not only increases progression-free survival but also prolongs OS [16]. The microenvironment in follicular lymphomas has also been reported to play a role in their susceptibility to immune manipulation [17], and recent data support the importance of the microenvironment (which contains immune effector cells) in the survival of MCL cells [18].

The antitumoral response may also be inhibited or stimulated by the reaction of the immune system to the presence of contemporaneous bacteria or viruses or a traumatic intervention [2, 17]. For example, a patient with plasmablastic lymphoma achieved SR after being given antiretroviral therapy against human immunodeficiency virus infection, presumably through the restoration of immune function [19]. In another postulated mechanism of SR in plasmablastic lymphoma, mobilization of the immune system against infection with the Epstein–Barr virus caused tumor regression [20]. A traumatic intervention such as a biopsy can also induce a regional increase in immune system activity and secondary antitumoral activity with subsequent SR [21].

The antitumoral activity of the immune system is believed to be mediated through cytotoxic T lymphocytes [21, 22]. A case report of SR in a patient with diffuse large B-cell lymphoma involving the right breast suggested that CD8-positive T cells might have contributed to the regression [22]. Moreover, in SR of primary cutaneous diffuse large B-cell lymphoma, leg type, immunohistochemical studies demonstrated the presence of lymphocytes positive for CD3, 4, and 8, cytotoxic molecules, granzyme B and T-cell-restricted intracellular antigen (TIA1), both in the vicinity of the tumor nest and in the tumor [21].

A more recent and exciting confirmation of the importance of the immune system, and of T cells in particular, in the treatment of lymphoma is chimeric antigen receptor (CAR) T-cell therapy [23, 24]. Kochenderfer et al. [23] reported that chemotherapy-refractory B-cell malignancies were successfully treated with anti-CD19 CAR T cells. However, data regarding CAR T-cell therapy for MCL are scant. In mouse xenograft models, CAR T cells can be activated by CD19 antigens expressed on the MCL cell surface [25], and MCL cells are sensitive to the CTL019 (cytotoxic T lymphocytes targeting CD19 antigens) effector function. There are currently two ongoing CAR T-cell clinical trials (KITE-C19-102 and KITE-2015-0372) at MD Anderson for the treatment of relapsed or refractory MCL, which have demonstrated promising results thus far (data not published).

Conclusions

In conclusion, the cases presented in this report support the use of a “wait and watch” strategy for MCL with no risk factors and indolent behavior, such as lack of B symptoms, normal lactate dehydrogenase (LDH) and β2 microglobulin (β2M) levels, a low MIPI score, a maximum tumor diameter of less than 3 cm, a low SUV on PET/CT (< 5), a Ki-67 value of < 30%, and non-blastoid cytology. In addition, this report describes the phenomenon of SR in MCL patients who are asymptomatic and have low-volume disease, which can spare patients from further potentially harmful chemotherapy if observed for regression. We also hypothesize that the host immune response through humoral and cellular immunity may play a central role in the clearance of tumor cells and contribute to spontaneous regression.

References

  1. 1.

    Horning SJ, Rosenberg SA. The natural history of initially untreated low-grade non-hodgkin’s lymphomas. N Engl J Med. 1984;311(23):1471–5.

    Article  PubMed  CAS  Google Scholar 

  2. 2.

    Drobyski WR, Qazi R. Spontaneous regression in non-hodgkin’s lymphoma: clinical and pathogenetic considerations. Am J Hematol. 1989;31(2):138–41.

    Article  PubMed  CAS  Google Scholar 

  3. 3.

    Martin P, Chadburn A, Christos P, et al. Outcome of deferred initial therapy in mantle-cell lymphoma. J Clin Oncol. 2009;27(8):1209–13.

    Article  PubMed  Google Scholar 

  4. 4.

    Kumar R, Bhargava P, Zhuang H, et al. Spontaneous regression of follicular, mantle cell, and diffuse large b-cell non-hodgkin’s lymphomas detected by FDG-PET imaging. Clin Nucl Med. 2004;29(11):685–8.

    Article  PubMed  Google Scholar 

  5. 5.

    Hoster E, Klapper W, Rosenwald A, et al. Cell proliferation (ki-67) as prognostic marker in mantle cell lymphoma. Blood. 2012;120:2677.

    Google Scholar 

  6. 6.

    Hoster E, Rosenwald A, Berger F, et al. Prognostic value of ki-67 index, cytology, and growth pattern in mantle-cell lymphoma: results from randomized trials of the european mantle cell lymphoma network. J Clin Oncol. 2016;34(12):1386–94.

    Article  PubMed  CAS  Google Scholar 

  7. 7.

    Karam M, Ata A, Irish K, et al. FDG positron emission tomography/computed tomography scan may identify mantle cell lymphoma patients with unusually favorable outcome. Nucl Med Commun. 2009;30(10):770–8.

    Article  PubMed  Google Scholar 

  8. 8.

    Yasui H, Nakamura Y, Hasegawa H, et al. A case of spontaneous regression of pulmonary mucosa-associated lymphoid tissue (malt) type lymphoma with Sjogren’s syndrome treated with methotrexate for rheumatoid arthritis. Respir Med Case Rep. 2015;15:4–6.

    PubMed  PubMed Central  Google Scholar 

  9. 9.

    Matsuo T, Ichimura K, Yoshino T. Spontaneous regression of bilateral conjunctival extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. J Clin Exp Hematopathol JCEH. 2007;47(2):79–81.

    Article  Google Scholar 

  10. 10.

    Matsuda I, Watanabe T, Enomoto Y, et al. Spontaneous regression of primary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (malt lymphoma) colliding with invasive ductal carcinoma of the breast: a case report. Int J Clin Exp Pathol. 2014;7(10):7020–7.

    PubMed  PubMed Central  Google Scholar 

  11. 11.

    Sato C, Suzuki H, Watanabe M, et al. Spontaneous regression of mucosa-associated lymphoid tissue lymphoma of the lung. Nihon Kokyuki Gakkai Zasshi. 2010;48(9):677–82.

    PubMed  Google Scholar 

  12. 12.

    Sekiguchi Y, Shimada A, Imai H, et al. Spontaneous regression of a clinically-advanced histologically low-grade follicular lymphoma involving the breast: case report and review of the literature. Indian J Hematol Blood Transfus. 2014;30(Suppl 1):320–4.

    Article  PubMed  PubMed Central  Google Scholar 

  13. 13.

    Thirukonda V, Petrich A, Parekh S. Classical hodgkin lymphoma and spontaneous regression. Clin Adv Hematol Oncol. 2012;10(11):765–6.

    PubMed  Google Scholar 

  14. 14.

    Abe R, Ogawa K, Maruyama Y, et al. Spontaneous regression of diffuse large B-cell lymphoma harbouring epstein-barr virus: a case report and review of the literature. J Clin Exp Hematopathol JCEH. 2007;47(1):23–6.

    Article  Google Scholar 

  15. 15.

    Chiu LS, Choi PC, Luk NM, et al. Spontaneous regression of primary cutaneous Epstein–Barr virus-positive, CD30-positive anaplastic large t-cell lymphoma in a heart-transplant recipient. Clin Exp Dermatol. 2009;34(5):e21–4.

    Article  PubMed  CAS  Google Scholar 

  16. 16.

    Solal-Celigny P, Lepage E, Brousse N, et al. Doxorubicin-containing regimen with or without interferon alfa-2b for advanced follicular lymphomas: final analysis of survival and toxicity in the Groupe d’Etude des lymphomes folliculaires 86 trial. J Clin Oncol. 1998;16(7):2332–8.

    Article  PubMed  CAS  Google Scholar 

  17. 17.

    Blaker YN, Spetalen S, Brodtkorb M, et al. The tumour microenvironment influences survival and time to transformation in follicular lymphoma in the rituximab era. Br J Haematol. 2016;175(1):102–14.

    Article  PubMed  CAS  Google Scholar 

  18. 18.

    Kurtova AV, Tamayo AT, Ford RJ, et al. Mantle cell lymphoma cells express high levels of CXCR4, CXCR5, and VLA-4 (CD49d): importance for interactions with the stromal microenvironment and specific targeting. Blood. 2009;113(19):4604–13.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  19. 19.

    Nasta SD, Carrum GM, Shahab I, et al. Regression of a plasmablastic lymphoma in a patient with hiv on highly active antiretroviral therapy. Leuk Lymphoma. 2002;43(2):423–6.

    Article  PubMed  Google Scholar 

  20. 20.

    Igawa T, Sato Y, Kawai H, et al. Spontaneous regression of plasmablastic lymphoma in an elderly human immunodeficiency virus (HIV)-negative patient. Diagn Pathol. 2015;10:183.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  21. 21.

    Jimura N, Fujii K, Baba A, et al. Spontaneous regression of a primary cutaneous diffuse large B-cell lymphoma, leg type. J Dermatol. 2016;44:608–9.

    Article  PubMed  Google Scholar 

  22. 22.

    Iihara K, Yamaguchi K, Nishimura Y, et al. Spontaneous regression of malignant lymphoma of the breast. Pathol Int. 2004;54(7):537–42.

    Article  PubMed  Google Scholar 

  23. 23.

    Kochenderfer JN, Dudley ME, Kassim SH, et al. Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous t cells expressing an anti-CD19 chimeric antigen receptor. J Clin Oncol. 2015;33(6):540–9.

    Article  PubMed  CAS  Google Scholar 

  24. 24.

    Schuster SJ, Svoboda J, Nasta SD, et al. Sustained remissions following chimeric antigen receptor modified t cells directed against CD19 (CTL019) in patients with relapsed or refractory CD19+ lymphomas. Blood. 2015;126:183.

    Google Scholar 

  25. 25.

    Ruella M, Kenderian SS, Shestova O, et al. The addition of the BTK inhibitor ibrutinib to anti-CD19 chimeric antigen receptor t cells (CART19) improves responses against mantle cell lymphoma. Clin Cancer Res. 2016;22(11):2684–96.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors’ contributions

HGY and AD collected the data and drafted the manuscript. MW and JR conceived the study and participated in its coordination. TJG, DFZ, KN, WC, and WW participated in the data interpretation and revision of the manuscript. All authors read and approved the final manuscript.

Acknowledgements

Supported by the generous philanthropic contributions to The University of Texas MD Anderson Moon Shots Program and Zhejiang Provincial Natural Science Foundation of China (LY13H080003).

Competing interests

The authors declare that they have no competing interests.

Availability of data and materials

Not applicable.

Consent for publication

The patients have given their consent for their cases report to be published.

Disclosure

Neither the submitted manuscript nor any similar manuscript, in whole or in part, other than an abstract, is under consideration, in press, published, or reported elsewhere.

Ethics approval and consent to participate

This manuscript was approved by the Ethics Committee on Scientific Research of MD Anderson Cancer Center.

Funding

This work was supported by the generous philanthropic contributions to The University of Texas MD Anderson Moon Shots Program. This work was also supported by Zhejiang Provincial Natural Science Foundation of China (LY13H080003) to Y.H.G.

Author information

Author notes

  1. Haige Ye and Aakash Desai contributed equally to this work

Affiliations

  1. Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, P. R. China

    Haige Ye

  2. Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA

    Haige Ye, Aakash Desai, Tiejun Gong, Dongfeng Zeng, Krystle Nomie, Wendy Chen, Wei Wang, Jorge Romaguera & Michael L. Wang

  3. The University of Texas Health Science Center, Houston, TX, 77030, USA

    Aakash Desai

  4. Institute of Hematology and Oncology, Harbin First Hospital, Harbin, 150000, Heilongjiang, P. R. China

    Tiejun Gong

  5. Department of Hematology, Da Ping Hospital, Research Institute of Surgery, Chongqing Third Military Medical University, Chongqing, 404100, P. R. China

    Dongfeng Zeng

Authors
  1. Haige Ye
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Aakash Desai
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tiejun Gong
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Dongfeng Zeng
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Krystle Nomie
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Wendy Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Wei Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Jorge Romaguera
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Michael L. Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Michael L. Wang.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Ye, H., Desai, A., Gong, T. et al. Spontaneous regression of mantle cell lymphoma: a report of four cases. Cancer Commun 38, 30 (2018). https://doi.org/10.1186/s40880-018-0306-z

Download citation

Keywords

  • Mantle cell lymphoma
  • Spontaneous regression

Cancer Communications

ISSN: 2523-3548

Contact us