Spontaneous regression of mantle cell lymphoma: a report of four cases

Cancer Communications

Table 1 Characteristics of four cases of spontaneous regression of mantle cell lymphoma (MCL)

Characteristic	Case 1	Case 2	Case 3	Case 4
Sex	Male	Female	Male	Male
Age (years)	48	44	63	68
B symptoms	No	No	No	No
LDH/ULN	0.72	0.59	0.62	0.85
β₂MG	Normal	Normal	Normal	Normal
s-MIPI score	2	1	2	2
Ki-67 value	10%–15%^a	10%	10%–15%^a	5%
Pathology pattern	Nodular^b	Nodular and diffuse	Diffuse^b	Mantle zone
Involved site (s)	Inguinal	Multiple	Right axillary	Inguinal, cervical
SUV of PET/CT	5.9–8.8	1.3–2.9	NA	2.6
Size of mass	2.5 × 1.4 cm	1.0 × 3.0 cm	1.3 × 1.1 cm	Sub-centimeter
SR	Complete	Partial	Complete	Complete
Time to SR (months)	12	5	3	53
Duration of SR^c (months)	18	14	33	20

LDH/ULN lactate dehydrogenase/upper limit normal, β₂MG β₂ microglobulin, s-MIPI simplified MCL-International Prognostic Index, SUV standardized uptake value, PET/CT positron emission tomography combined with computed tomography, SR spontaneous regression, NA not available
^a Initial Ki-67 value
^b Initial pathology pattern, not after relapse
^c Still in SR at last follow-up

ISSN: 2523-3548