Charbonneau H, Tonks NK, Kumar S, et al. Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins. Proc Natl Acad Sci U S A, 1989,86:5252–5256.
Article
PubMed Central
CAS
PubMed
Google Scholar
Czernilofsky AP, Levinson AD, Varmus HE, et al. Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposec amino acid sequence for gene product. Nature, 1980,287:198–203.
Article
CAS
PubMed
Google Scholar
Guan KL, Haun RS, Watson SJ, et al. Cloning and expression of a protein-tyrosine-phosphatase. Proc Natl Acad Sci U S A, 1990,87:1501–1505.
Article
PubMed Central
CAS
PubMed
Google Scholar
Alonso A, Sasin J, Bottini N, et al. Protein tyrosine phosphatases in the human genome. Cell, 2004,117:699–711.
Article
CAS
PubMed
Google Scholar
Buist A, Zhang YL, Keng YF, et al. Restoration of potent protein-tyrosine phosphatase activity into the membrane-distal domain of receptor protein-tyrosine phosphatase alpha. Biochemistry, 1999,38:914–922.
Article
CAS
PubMed
Google Scholar
Blanchetot C, Tertoolen LG, Overvoorde J, et al. Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases. J Biol Chem, 2002,277:47263–47269.
Article
CAS
PubMed
Google Scholar
Bilwes AM, den Hertog J, Hunter T, et al. Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization. Nature, 1996,382:555–559.
Article
CAS
PubMed
Google Scholar
Nam HJ, Poy F, Saito H, et al. Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45. J Exp Med, 2005,201:441–452.
Article
PubMed Central
CAS
PubMed
Google Scholar
Nam HJ, Poy F, Krueger NX, et al. Crystal structure of the tandem phosphatase domains of RPTP LAR. Cell, 1999,97:449–457.
Article
CAS
PubMed
Google Scholar
Salmeen A, Barford D. Functions and mechanisms of redox regulation of cysteine-based phosphatases. Antioxid Redox Signal, 2005,7:560–577.
Article
CAS
PubMed
Google Scholar
Salmeen A, Andersen JN, Myers MP, et al. Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate. Nature, 2003,423:769–773.
Article
CAS
PubMed
Google Scholar
Julien SG, Dube N, Hardy S, et al. Inside the human cancer tyrosine phosphatome. Nat Rev Cancer, 2011,11:35–49.
Article
CAS
PubMed
Google Scholar
Wang Z, Shen D, Parsons DW, et al. Mutational analysis of the tyrosine phosphatome in colorectal cancers. Science, 2004,304:1164–1166.
Article
CAS
PubMed
Google Scholar
Stransky N, Egloff AM, Tward AD, et al. The mutational landscape of head and neck squamous cell carcinoma. Science, 2011,333:1157–1160.
Article
PubMed Central
CAS
PubMed
Google Scholar
Becker H, Yoshida K, Blagitko-Dorfs N, et al. Tracing the development of acute myeloid leukemia in CBL syndrome. Blood, 2014,123:1883–1886.
Article
CAS
PubMed
Google Scholar
Andersson EI, Rajala HL, Eldfors S, et al. Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation. Blood Cancer J, 2013,3:e168.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lui VW, Peyser ND, Ng PK, et al. Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer. Proc Natl Acad Sci U S A, 2014,111:1114–1119.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lambert SR, Harwood CA, Purdie KJ, et al. Metastatic cutaneous squamous cell carcinoma shows frequent deletion in the protein tyrosine phosphatase receptor type D gene. Int J Cancer, 2012,131:E216–E226.
Article
CAS
PubMed
Google Scholar
Solomon DA, Kim JS, Cronin JC, et al. Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma. Cancer Res, 2008,68:10300–10306.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sjoblom T, Jones S, Wood LD, et al. The consensus coding sequences of human breast and colorectal cancers. Science, 2006,314:268–274.
Article
PubMed
Google Scholar
Kohno T, Otsuka A, Girard L, et al. A catalog of genes homozygously deleted in human lung cancer and the candidacy of PTPRD as a tumor suppressor gene. Genes Chromosomes Cancer, 2010,49:342–352.
PubMed Central
CAS
PubMed
Google Scholar
Ding L, Getz G, Wheeler DA, et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature, 2008,455:1069–1075.
Article
PubMed Central
CAS
PubMed
Google Scholar
Meehan M, Parthasarathi L, Moran N, et al. Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase A oncogene. Mol Cancer, 2012,11:6.
Article
PubMed Central
CAS
PubMed
Google Scholar
Veeriah S, Brennan C, Meng S, et al. The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers. Proc Natl Acad Sci U S A, 2009,106:9435–9440.
Article
PubMed Central
CAS
PubMed
Google Scholar
Behjati S, Tarpey PS, Sheldon H, et al. Recurrent PTPRB and PLCG1 mutations in angiosarcoma. Nat Genet, 2014,46:376–379.
Article
PubMed Central
CAS
PubMed
Google Scholar
Purdie KJ, Lambert SR, Teh MT, et al. Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis. Genes Chromosomes Cancer, 2007,46:661–669.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zhao X, Weir BA, LaFramboise T, et al. Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis. Cancer Res, 2005,65:5561–5570.
Article
CAS
PubMed
Google Scholar
Stark M, Hayward N. Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays. Cancer Res, 2007,67:2632–2642.
Article
CAS
PubMed
Google Scholar
Dutton-Regester K, Aoude LG, Nancarrow DJ, et al. Identification of TFG (TRK-fused gene) as a putative metastatic melanoma tumor suppressor gene. Genes Chromosomes Cancer, 2012,51:452–461.
Article
CAS
PubMed
Google Scholar
Stallings RL, Nair P, Maris JM, et al. High-resolution analysis of chromosomal breakpoints and genomic instability identifies PTPRD as a candidate tumor suppressor gene in neuroblastoma. Cancer Res, 2006,66:3673–3680.
Article
CAS
PubMed
Google Scholar
Micci F, Panagopoulos I, Haugom L, et al. Genomic aberration patterns and expression profiles of squamous cell carcinomas of the vulva. Genes Chromosomes Cancer, 2013,52:551–563.
Article
CAS
PubMed
Google Scholar
Nalesnik MA, Tseng G, Ding Y, et al. Gene deletions and amplifications in human hepatocellular carcinomas: correlation with hepatocyte growth regulation. Am J Pathol, 2012,180:1495–1508.
Article
PubMed Central
CAS
PubMed
Google Scholar
Giefing M, Zemke N, Brauze D, et al. High resolution ArrayCGH and expression profiling identifies PTPRD and PCDH17/PCH68 as tumor suppressor gene candidates in laryngeal squamous cell carcinoma. Genes Chromosomes Cancer, 2011,50:154–166.
Article
CAS
PubMed
Google Scholar
Aarts M, Dannenberg H, deLeeuw RJ, et al. Microarray-based CGH of sporadic and syndrome-related pheochromocytomas using a 0.1–0.2 Mb bacterial artificial chromosome array spanning chromosome arm 1p. Genes chromosomes Cancer, 2006,45:83–93.
Article
CAS
PubMed
Google Scholar
Bera R, Chiou CY, Yu MC, et al. Functional genomics identified a novel protein tyrosine phosphatase receptor type F-mediated growth inhibition inhepatocarcinogenesis. Hepatology, 2014,59:2238–2250.
Article
CAS
PubMed
Google Scholar
Shu ST, Sugimoto Y, Liu S, et al. Function and regulatory mechanisms of the candidate tumor suppressor receptor protein tyrosine phosphatase gamma (PTPRG) in breast cancer cells. Anticancer Res, 2010,30:1937–1946.
CAS
PubMed
Google Scholar
Wang JF, Dai DQ. Metastatic suppressor genes inactivated by aberrant methylation in gastric cancer. World J Gastroenterol, 2007,13:5692–5698.
Article
PubMed Central
CAS
PubMed
Google Scholar
Cheung AK, Lung HL, Hung SC, et al. Functional analysis of a cell cycle-associated, tumor-suppressive gene, protein tyrosine phosphatase receptor type G, in nasopharyngeal carcinoma. Cancer Res, 2008,68:8137–8145.
Article
CAS
PubMed
Google Scholar
van Roon EH, de Miranda NF, van Nieuwenhuizen MP, et al. Tumour-specific methylation of PTPRG intron 1 locus in sporadic and Lynch syndrome colorectal cancer. EurJ Hum Genet, 2011,19:307–312.
Article
Google Scholar
Xiao J, Lee ST, Xiao Y, et al. PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia. Int J Cancer, 2014,135:1101–1109.
Article
CAS
PubMed
Google Scholar
van Doorn R, Zoutman WH, Dijkman R, et al. Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73. J Clin Oncol, 2005,23:3886–3896.
Article
PubMed
Google Scholar
Motiwala T, Ghoshal K, Das A, et al. Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas. Oncogene, 2003,22:6319–6331.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hsu SH, Motiwala T, Roy S, et al. Methylation of the PTPRO gene in human hepatocellular carcinoma and identification of VCP as its substrate. J Cell Biochem, 2013,114:1810–1818.
Article
PubMed Central
CAS
PubMed
Google Scholar
Mori Y, Yin J, Sato F, et al. Identification of genes uniquely involved in frequent microsatellite instability colon carcinogenesis by expression profiling combined with epigenetic scanning. Cancer Res, 2004,64:2434–2438.
Article
CAS
PubMed
Google Scholar
Motiwala T, Kutay H, Ghoshal K, et al. Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer. Proc Natl Acad Sci U S A, 2004,101:13844–13849.
Article
PubMed Central
CAS
PubMed
Google Scholar
Motiwala T, Majumder S, Kutay H, et al. Methylation and silencing of protein tyrosine phosphatase receptor type O in chronic lymphocytic leukemia. Clin Cancer Res, 2007,13:3174–3181.
Article
PubMed Central
CAS
PubMed
Google Scholar
You YJ, Chen YP, Zheng XX, et al. Aberrant methylation of the PTPRO gene in peripheral blood as a potential biomarker in esophageal squamous cell carcinoma patients. Cancer Lett, 2012,315:138–144.
Article
PubMed Central
CAS
PubMed
Google Scholar
Li SY, Li R, Chen YL, et al. Aberrant PTPRO methylation in tumor tissues as a potential biomarker that predicts clinical outcomes in breast cancer patients. BMC Genet, 2014,15:67.
Article
PubMed Central
PubMed
Google Scholar
Phillips JM, Goodman JI. Identification of genes that may play critical roles in phenobarbital (PB)-induced liver tumorigenesis due to altered DNA methylation. Toxicol Sci, 2008,104:86–99.
Article
CAS
PubMed
Google Scholar
Venkatachalam R, Ligtenberg MJ, Hoogerbrugge N, et al. Germline epigenetic silencing of the tumor suppressor gene PTPRJ in early-onset familial colorectal cancer. Gastroenterology, 2010,139:2221–2224.
Article
PubMed
Google Scholar
Laczmanska I, Karpinski P, Bebenek M, et al. Protein tyrosine phosphatase receptor-like genes are frequently hypermethylated in sporadic colorectal cancer. J Hum Genet, 2013,58:11–15.
Article
CAS
PubMed
Google Scholar
Junnila S, Kokkola A, Karjalainen-Lindsberg ML, et al. Genomewide gene copy number and expression analysis of primary gastric tumors and gastric cancer cell lines. BMC Cancer, 2010,10:73.
Article
PubMed Central
PubMed
Google Scholar
Ardini E, Agresti R, Tagliabue E, et al. Expression of protein tyrosine phosphatase alpha (RPTPalpha) in human breast cancer correlates with low tumor grade, and inhibits tumor cell growth in vitro and in vivo. Oncogene, 2000,19:4979–4987.
Article
CAS
PubMed
Google Scholar
Harder KW, Saw J, Miki N, et al. Coexisting amplifications of the chromosome 1p32 genes (PTPRF and MYCL1) encoding protein tyrosine phosphatase LAR and L-myc in a small cell lung cancer line. Genomics, 1995,27:552–553.
Article
CAS
PubMed
Google Scholar
Seo Y, Matozaki T, Tsuda M, et al. Overexpression of SAP-1, a transmembrane-type protein tyrosine phosphatase, in human colorectal cancers. Biochem Biophys Res Commun, 1997,231:705–711.
Article
CAS
PubMed
Google Scholar
Su J, Muranjan M, Sap J. Receptor protein tyrosine phosphatase alpha activates Src-family kinases and controls integrin-mediated responses in fibroblasts. Curr Biol, 1999,9:505–511.
Article
CAS
PubMed
Google Scholar
Zheng X, Resnick RJ, Shalloway D. Apoptosis of estrogen-receptor negative breast cancer and colon cancer cell lines by PTP alpha and src RNAi. Int J Cancer, 2008,122:1999–2007.
Article
CAS
PubMed
Google Scholar
Meyer DS, Aceto N, Sausgruber N, et al. Tyrosine phosphatase PTPalpha contributes to HER2-evoked breast tumor initiation and maintenance. Oncogene, 2014,33:398–402.
Article
CAS
PubMed
Google Scholar
Granot-Attas S, Elson A. Protein tyrosine phosphatase epsilon activates Yes and Fyn in Neu-induced mammary tumor cells. Exp Cell Res, 2004,294:236–243.
Article
CAS
PubMed
Google Scholar
Kraut-Cohen J, Muller WJ, Elson A. Protein-tyrosine phosphatase epsilon regulates Shc signaling in a kinase-specific manner: increasing coherence in tyrosine phosphatase signaling. J Biol Chem, 2008,283:4612–4621.
Article
CAS
PubMed
Google Scholar
Wang WJ, Kuo JC, Ku W, et al. The tumor suppressor DAPK is reciprocally regulated by tyrosine kinase Src and phosphatase LAR. Mol Cell, 2007,27:701–716.
Article
PubMed
Google Scholar
DaSilva JO, Amorino GP, Casarez EV, et al. Neuroendocrine-derived peptides promote prostate cancer cell survival through activation of IGF-1R signaling. Prostate, 2013,73:801–812.
Article
PubMed Central
CAS
PubMed
Google Scholar
Della Peruta M, Martinelli G, Moratti E, et al. Protein tyrosine phosphatase receptor type (gamma) is a functional tumor suppressor gene specifically downregulated in chronic myeloid leukemia. Cancer Rres, 2010,70:8896–8906.
Article
Google Scholar
Takada T, Noguchi T, Inagaki K, et al. Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1. J Biol Chem, 2002,277:34359–34366.
Article
CAS
PubMed
Google Scholar
Chabot C, Spring K, Gratton JP, et al. New role for the protein tyrosine phosphatase DEP-1 in akt activation and endothelial cell survival. Mol Cell Biol, 2009,29:241–253.
Article
PubMed Central
CAS
PubMed
Google Scholar
Spring K, Chabot C, Langlois S, et al. Tyrosine phosphorylation of DEP-1/CD148 as a mechanism controlling Src kinase activation, endothelial cell permeability, invasion, and capillary formation. Blood, 2012,120:2745–2756.
Article
CAS
PubMed
Google Scholar
Hayashi M, Majumdar A, Li X, et al. VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation. Nat Commun, 2013,4:1672.
Article
PubMed Central
PubMed
Google Scholar
Veeriah S, Brennan C, Meng S, et al. The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers. Proc Natl Acad Sci U S A, 2009,106:9435–9440.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ortiz B, Fabius AW, Wu WH, et al. Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis. Proc Natl Acad Sci U S A, 2014,111:8149–8154.
Article
PubMed Central
CAS
PubMed
Google Scholar
Qi J, Li N, Fan K, et al. Beta1,6 GlcNAc branches-modified PTPRT attenuates its activity and promotes cell migration by STAT3 pathway. PLoS One, 2014,9:e98052.
Article
PubMed Central
PubMed
Google Scholar
Zhang X, Guo A, Yu J, et al. Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T. Proc Natl Acad Sci U S A, 2007,104:4060–4064.
Article
PubMed Central
CAS
PubMed
Google Scholar
Boivin B, Chaudhary F, Dickinson BC, et al. Receptor protein-tyrosine phosphatase alpha regulates focal adhesion kinase phosphorylation and ErbB2 oncoprotein-mediated mammary epithelial cell motility. J Biol Chem, 2013,288:36926–36935.
Article
PubMed Central
CAS
PubMed
Google Scholar
Krndija D, Schmid H, Eismann JL, et al. Substrate stiffness and the receptor-type tyrosine-protein phosphatase alpha regulate spreading of colon cancer cells through cytoskeletal contractility. Oncogene, 2010,29:2724–2738.
Article
CAS
PubMed
Google Scholar
Muller T, Choidas A, Reichmann E, et al. Phosphorylation and free pool of beta-catenin are regulated by tyrosine kinases and tyrosine phosphatases during epithelial cell migration. J Biol Chem, 1999,274:10173–10183.
Article
CAS
PubMed
Google Scholar
Silver DJ, Siebzehnrubl FA, Schildts MJ, et al. Chondroitin sulfate proteoglycans potently inhibit invasion and serve as a central org anizer of the brain tumor microenvironment. J Neurosci, 2013,33:15603–15617.
Article
PubMed Central
CAS
PubMed
Google Scholar
Noguchi T, Tsuda M, Takeda H, et al. Inhibition of cell growth and spreading by stomach cancer-associated protein-tyrosine phosphatase-1 (SAP-1) through dephosphorylation of p130cas. J Biol Chem, 2001,276:15216–15224.
Article
CAS
PubMed
Google Scholar
Kellie S, Craggs G, Bird IN, et al. The tyrosine phosphatase DEP-1 induces cytoskeletal rearrangements, aberrant cell-substratum interactions and a reduction in cell proliferation. J Cell Sci, 2004,117:609–618.
Article
CAS
PubMed
Google Scholar
Kim HS, Kim SC, Kim SJ, et al. Identification of a radiosensitivity signature using integrative metaanalysis of published microarray data for NCI-60 cancer cells. BMC Genomics, 2012,13:348.
Article
PubMed Central
CAS
PubMed
Google Scholar
Huang L, Zheng M, Zhou QM, et al. Identification of a 7-gene signature that predicts relapse and survival for early stage patients with cervical carcinoma. Med Oncol, 2012,29:2911–2918.
Article
CAS
PubMed
Google Scholar
Whitmore TE, Peterson A, Holzman T, et al. Integrative analysis of N-linked human glycoproteomic data sets reveals PTPRF ectodomain as a novel plasma biomarker candidate for prostate cancer. J Proteome Res, 2012,11:2653–2665.
Article
CAS
PubMed
Google Scholar
Yang X, Li J, Zhou Y, et al. Discovery of novel inhibitor of human leukocyte common antigen-related phosphatase. Biochim Biophys Acta, 2005,1726:34–41.
Article
CAS
PubMed
Google Scholar
Ajay D, Sobhia ME. Identification of novel, less toxic PTP-LAR inhibitors using in silico strategies: pharmacophore modeling, SADMET-based virtual screening and docking. J Mol Model, 2012,18:187–201.
Article
CAS
PubMed
Google Scholar
Keane MM, Lowrey GA, Ettenberg SA, et al. The protein tyrosine phosphatase DEP-1 is induced during differentiation and inhibits growth of breast cancer cells. Cancer Res, 1996,56:4236–4243.
CAS
PubMed
Google Scholar
Trapasso F, Yendamuri S, Dumon KR, et al. Restoration of receptor-type protein tyrosine phosphatase eta function inhibits human pancreatic carcinoma cell growth in vitro and in vivo. Carcinogenesis, 2004,25:2107–2114.
Article
CAS
PubMed
Google Scholar
Luo L, Shen GQ, Stiffler KA, et al. Loss of heterozygosity in human aberrant crypt foci (ACF), a putative precursor of colon cancer. Carcinogenesis, 2006,27:1153–1159.
Article
CAS
PubMed
Google Scholar
Paduano F, Ortuso F, Campiglia P, et al. Isolation and functional characterization of peptide agonists of PTPRJ, a tyrosine phosphatase receptor endowed with tumor suppressor activity. ACS Chem Biol, 2012,7:1666–1676.
Article
CAS
PubMed
Google Scholar
Ortuso F, Paduano F, Carotenuto A, et al. Discovery of PTPRJ agonist peptides that effectively inhibit in vitro cancer cell proliferation and tube formation. ACS Chem Biol, 2013,8:1497–1506.
Article
CAS
PubMed
Google Scholar