Table 1 The type of post-translational modification that Parkin participates in and its biological function
From: Post-translational modification of Parkin and its research progress in cancer
Post-translational modification type | Modification site | Modification of related enzymes | Biological functions |
|---|---|---|---|
Phosphorylation | Serine, threonine, tyrosine | Protein kinase, protein phosphatase | Signal transduction, cell cycle, growth and development, cancer mechanism |
Ubiquitination | Lysine | Ubiquitin activating enzyme, binding enzyme, ligase and degrading enzyme, ubiquitin-specific protease | Cell proliferation, apoptosis, DNA damage repair, Immune response |
Sumoylation | Lysine | SUMO-specific protease | Mitochondrial division, DNA damage repair, genomic stability |
Neddylation | Lysine | NEDD8 activating enzyme, Cullin E3 enzyme | Cell cycle, signal transduction, apoptosis |
S-Nitrosylation | Cysteine | Nitric oxide synthase | Apoptosis, inflammatory response, immunosuppression |