Overman MJ, Hu CY, Kopetz S, Abbruzzese JL, Wolff RA, Chang GJ. A population-based comparison of adenocarcinoma of the large and small intestine: insights into a rare disease. Ann Surg Oncol. 2012;19(5):1439–45.
Article
PubMed
Google Scholar
Cloyd JM, George E, Visser BC. Duodenal adenocarcinoma: advances in diagnosis and surgical management. World J Gastrointest Surg. 2016;8(3):212–21.
Article
PubMed
PubMed Central
Google Scholar
Lee HG, You DD, Paik KY, Heo JS, Choi SH, Choi DW. Prognostic factors for primary duodenal adenocarcinoma. World J Surg. 2008;32(10):2246–52.
Article
PubMed
Google Scholar
Ecker BL, McMillan MT, Datta J, Mamtani R, Giantonio BJ, Dempsey DT, et al. Efficacy of adjuvant chemotherapy for small bowel adenocarcinoma: a propensity score-matched analysis. Cancer. 2016;122(5):693–701.
Article
PubMed
Google Scholar
Ecker BL, McMillan MT, Datta J, Lee MK, Karakousis GC, Vollmer CM Jr, et al. Adjuvant chemotherapy versus chemoradiotherapy in the management of patients with surgically resected duodenal adenocarcinoma: a propensity score-matched analysis of a nationwide clinical oncology database. Cancer. 2017;123(6):967–76.
Article
PubMed
CAS
Google Scholar
Sheikine Y, Kuo FC, Lindeman NI. Clinical and technical aspects of genomic diagnostics for precision oncology. J Clin Oncol. 2017;35(9):929–33.
Article
PubMed
CAS
Google Scholar
Garnett MJ, Edelman EJ, Heidorn SJ, Greenman CD, Dastur A, Lau KW, et al. Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature. 2012;483(7391):570–5.
Article
PubMed
PubMed Central
CAS
Google Scholar
Cirulli ET, Singh A, Shianna KV, Ge D, Smith JP, Maia JM, et al. Center for HIVAVI. Screening the human exome: a comparison of whole genome and whole transcriptome sequencing. Genome Biol. 2010;11(5):R57.
Article
PubMed
PubMed Central
CAS
Google Scholar
Wilkerson MD, Cabanski CR, Sun W, Hoadley KA, Walter V, Mose LE, et al. Integrated rna and DNA sequencing improves mutation detection in low purity tumors. Nucleic Acids Res. 2014;42(13):e107.
Article
PubMed
PubMed Central
CAS
Google Scholar
Girotti MR, Gremel G, Lee R, Galvani E, Rothwell D, Viros A, et al. Application of sequencing, liquid biopsies, and patient-derived xenografts for personalized medicine in melanoma. Cancer Discov. 2016;6(3):286–99.
Article
PubMed
CAS
Google Scholar
Aparicio S, Hidalgo M, Kung AL. Examining the utility of patient-derived xenograft mouse models. Nat Rev Cancer. 2015;15(5):311–6.
Article
PubMed
CAS
Google Scholar
Hidalgo M, Amant F, Biankin AV, Budinska E, Byrne AT, Caldas C, et al. Patient-derived xenograft models: an emerging platform for translational cancer research. Cancer Discov. 2014;4(9):998–1013.
Article
PubMed
PubMed Central
CAS
Google Scholar
Izumchenko E, Meir J, Bedi A, Wysocki PT, Hoque MO, Sidransky D. Patient-derived xenografts as tools in pharmaceutical development. Clin Pharmacol Ther. 2016;99(6):612–21.
Article
PubMed
CAS
Google Scholar
Zhang L, Nomie K, Zhang H, Bell T, Pham L, Kadri S, et al. B-cell lymphoma patient-derived xenograft models enable drug discovery and are a platform for personalized therapy. Clin Cancer Res. 2017;23(15):4212–23.
Article
PubMed
PubMed Central
CAS
Google Scholar
Byrne AT, Alferez DG, Amant F, Annibali D, Arribas J, Biankin AV, Trusolino L, et al. Interrogating open issues in cancer precision medicine with patient-derived xenografts. Nat Rev Cancer. 2017;17(4):254–68.
Article
PubMed
CAS
Google Scholar
Mose LE, Wilkerson MD, Hayes DN, Perou CM, Parker JS. Abra: improved coding indel detection via assembly-based realignment. Bioinformatics. 2014;30(19):2813–5.
Article
PubMed
PubMed Central
CAS
Google Scholar
Boeva V, Popova T, Bleakley K, Chiche P, Cappo J, Schleiermacher G, et al. Control-freec: a tool for assessing copy number and allelic content using next-generation sequencing data. Bioinformatics. 2012;28(3):423–5.
Article
PubMed
CAS
Google Scholar
Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, Gingeras TR, et al. Star: ultrafast universal rna-seq aligner. Bioinformatics. 2013;29(1):15–21.
Article
PubMed
CAS
Google Scholar
Neoptolemos JP, Moore MJ, Cox TF, Valle JW, Palmer DH, McDonald AC, European Study Group for Pancreatic C, et al. Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the espac-3 periampullary cancer randomized trial. JAMA. 2012;308(2):147–56.
Article
PubMed
CAS
Google Scholar
Garber K. From human to mouse and back: ‘Tumorgraft’ models surge in popularity. J Natl Cancer Inst. 2009;101(1):6–8.
Article
PubMed
Google Scholar
Hwang CI, Boj SF, Clevers H, Tuveson DA. Preclinical models of pancreatic ductal adenocarcinoma. J Pathol. 2016;238(2):197–204.
Article
PubMed
Google Scholar
Solaini L, Jamieson NB, Metcalfe M, Abu Hilal M, Soonawalla Z, Davidson BR, Group UKDCS., et al. Outcome after surgical resection for duodenal adenocarcinoma in the uk. Br J Surg. 2015;102(6):676–81.
Article
PubMed
CAS
Google Scholar
Jiang QL, Huang XH, Zhang JW, Zhang SS, Wang CF. Evaluation of disease free survival after radical resection for primary duodenal adenocarcinoma. Zhonghua Yi Xue Za Zhi. 2016;96(42):3393–7.
PubMed
CAS
Google Scholar
Fu T, Guzzetta AA, Jeschke J, Vatapalli R, Dave P, Hooker CM, et al. Kras g>a mutation favors poor tumor differentiation but may not be associated with prognosis in patients with curatively resected duodenal adenocarcinoma. Int J Cancer. 2013;132(11):2502–9.
Article
PubMed
PubMed Central
CAS
Google Scholar
Baines AT, Xu D, Der CJ. Inhibition of ras for cancer treatment: the search continues. Future Med Chem. 2011;3(14):1787–808.
Article
PubMed
CAS
Google Scholar
Wang Y, Kaiser CE, Frett B, Li HY. Targeting mutant kras for anticancer therapeutics: a review of novel small molecule modulators. J Med Chem. 2013;56(13):5219–30.
Article
PubMed
PubMed Central
CAS
Google Scholar
Rodrik-Outmezguine VS, Okaniwa M, Yao Z, Novotny CJ, McWhirter C, Banaji A, et al. Overcoming mtor resistance mutations with a new-generation mtor inhibitor. Nature. 2016;534(7606):272–6.
Article
PubMed
PubMed Central
CAS
Google Scholar
Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, et al. Ablation in mice of the mtorc components raptor, rictor, or mlst8 reveals that mtorc2 is required for signaling to akt-foxo and pkcalpha, but not s6k1. Dev Cell. 2006;11(6):859–71.
Article
PubMed
CAS
Google Scholar
Kim ST, Kim SY, Klempner SJ, Yoon J, Kim N, Ahn S, et al. Rapamycin-insensitive companion of mtor (rictor) amplification defines a subset of advanced gastric cancer and is sensitive to azd2014-mediated mtorc1/2 inhibition. Ann Oncol. 2017;28(3):547–54.
PubMed
CAS
Google Scholar
Driscoll DR, Karim SA, Sano M, Gay DM, Jacob W, Yu J, et al. Mtorc2 signaling drives the development and progression of pancreatic cancer. Cancer Res. 2016;76(23):6911–23.
Article
PubMed
PubMed Central
CAS
Google Scholar
Liu P, Gan W, Chin YR, Ogura K, Guo J, Zhang J, et al. Ptdins(3,4,5)p3-dependent activation of the mtorc2 kinase complex. Cancer Discov. 2015;5(11):1194–209.
Article
PubMed
PubMed Central
CAS
Google Scholar
Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, Meyerson M, et al. The landscape of somatic copy-number alteration across human cancers. Nature. 2010;463(7283):899–905.
Article
PubMed
PubMed Central
CAS
Google Scholar
Wei G, Margolin AA, Haery L, Brown E, Cucolo L, Julian B, Golub TR, et al. Chemical genomics identifies small-molecule mcl1 repressors and bcl-xl as a predictor of mcl1 dependency. Cancer Cell. 2012;21(4):547–62.
Article
PubMed
PubMed Central
CAS
Google Scholar
Kotschy A, Szlavik Z, Murray J, Davidson J, Maragno AL, Le Toumelin-Braizat G, et al. The mcl1 inhibitor s63845 is tolerable and effective in diverse cancer models. Nature. 2016;538(7626):477–82.
Article
PubMed
CAS
Google Scholar