Fig. 4

Metabolic recoding of epigenetics in cancer. a A model of random metabolic recoding of epigenetics in cancer. b Dose-dependent effect of metabolites on epigenetic enzymes. Higher accumulation of a specific metabolite affects more epigenetic targets. Half-maximal inhibitory concentrations (IC₅₀) of different target epigenetic enzymes are indicated as triangles. Different colors of triangles represent different epigenetic enzymes. c Metabolic enzymes translocate to the nucleus, where they bind to transcription factors that carry the enzymes to specific target sequences in the genome. d Nutrient sensing and signaling modulate the epigenetic machinery