Fig. 1

Pedigree of the family. Squares indicate males, and circles represent females. Slashed symbols indicate deceased individuals. Unfilled symbols indicate unaffected individuals. Black dotted circles indicate unaffected individuals carrying the androgen receptor (AR) gene mutation. Half-black shaded symbols represent individuals carrying the AR gene mutation who are affected by partial androgen insensitivity syndrome (PAIS). The blue arrow indicates the proband. The half-blue shaded symbol indicates that the proband presented with colorectal cancer (CRC). y.o. indicates the age at the time of the analysis. The proband developed primary CRC at 27 years old, metachronous CRC at 30 years old, and recurrent CRC at 31 years old