Table 2 Univariate and multivariate analyses of variables associated with progression-free survival of patients with newly diagnosed metastatic colorectal cancer

Gender

0.931

 Male

1 (reference)

1 (reference)

 Female

0.984 (0.815–1.189)

0.992 (0.819–1.200)

Age (years)

0.837

 <65

1 (reference)

1 (reference)

 ≥65

0.991 (0.714–1.207)

0.837 (0.668–1.408)

ECOG performance status

<0.001

 <2

1 (reference)

1 (reference)

 ≥2

1.300 (1.066–1.585)

1.515 (1.206–1.907)

Site of primary tumor

0.560

 Colon

1 (reference)

1 (reference)

 Rectum

1.060 (0.878–1.280)

1.058 (0.876–1.278)

No. of metastatic sites

0.049

 ≤2

1 (reference)

1 (reference)

 >2

1.388 (1.148–1.680)

1.229 (1.001–1.509)

Tumor differentiation

0.005

 Well or moderate

1 (reference)

1 (reference)

 Poor

1.617 (1.334–1.961)

1.354 (1.095–1.675)

Pre-chemotherapy ALC (× 10⁹/L)

0.059

 <2.70

1 (reference)

1 (reference)

 ≥2.70

0.841 (0.697–1.015)

0.792 (0.621–1.009)

Pre-chemotherapy AMC (× 10⁹/L)

0.001

 <0.55

1 (reference)

1 (reference)

 ≥0.55

1.409 (1.159–1.713)

1.513 (1.172–1.954)

Pre-chemotherapy LMR

0.005

 <3.11

1 (reference)

1 (reference)

 ≥3.11

0.552 (0.454–0.671)

0.710 (0.558–0.903)