Cytokine-induced killer (CIK) cells: from basic research to clinical translation

Cancer Communications

Table 1 Differential cytokine and receptor expression of cytokine-induced killer (CIK) cells upon stimulation by tumor cells

Cytokine/receptor	Secretion/expression status
Cytokine/receptor	With stimulus	Without stimulus
IL-2	+	+
IFN-γ	+	+
TNF-α	+	+
GM-CSF	+	-
IL-4	+	-
IL-2R	+	+
IL-4R	+	+
IL-10R	-	+
IL-12R	+	-
IL-15R	+	-

IL-2, interleukin 2; IL-4, interleukin 4; IFN-γ, interferon γ; TNF-α, tumor necrosis factor α; GM-CSF, granulocyte-macrophage colony-stimulating factor; IL-2R, interleukin 2 receptor; IL-4R, interleukin 4 receptor; IL-10R, interleukin 10 receptor; IL-12R, interleukin 12 receptor; IL-15R, interleukin 15 receptor. “+” indicates secreted or expressed; “-” indicates not secreted or expressed.

ISSN: 2523-3548