Table 2. Analysis of potential predictors of time to treatment response among 25 patients (39 tumors) with hepatocellular carcinoma treated with radiotherapy
Variable | Cases | Median time to objective response (months) | P value | |
|---|---|---|---|---|
Univariate | Multivariate | |||
Age (years) | 0.001 | 0.005 | ||
< 60 | 16 | 3.8 | ||
⩾ 60 | 23 | 5.0 | ||
Sex | 0.081 | 0.342 | ||
Men | 27 | 4.0 | ||
Women | 12 | 5.0 | ||
ECOG performance status | 0.391 | 0.785 | ||
0 | 18 | 3.8 | ||
1–2 | 21 | 5.0 | ||
Tumor size (cm) | 0.489 | 0.380 | ||
< 1.7 | 18 | 4.5 | ||
⩾ 1.7 | 21 | 3.9 | ||
GTV (cm3) | 0.195 | 0.847 | ||
< 7 | 20 | 4.9 | ||
⩾ 7 | 19 | 3.8 | ||
Pre-radiotherapy AFP concentration (IU/mL) | 0.270 | 0.625 | ||
< 25 | 20 | 4.0 | ||
⩾ 25 | 19 | 4.5 | ||
AFP concentration change | 0.003 | 0.047 | ||
< 1 | 19 | 4.0 | ||
⩾ 1 | 20 | 6.1 | ||
Total radiotherapy dose (Gy10) | 0.586 | 0.666 | ||
< 67 | 18 | 4.5 | ||
⩾ 67 | 21 | 3.9 | ||
Daily radiotherapy dose (Gy) | 0.672 | 0.928 | ||
< 2.5 | 13 | 3.0 | ||
⩾ 2.5 | 26 | 4.9 | ||
Pre-radiotherapy TACE | 0.178 | 0.650 | ||
Yes | 23 | 3.8 | ||
No | 16 | 4.9 | ||