Skip to main content

Table 1 The prognostic values of immune landscape markers in EC

From: The immune landscape of esophageal cancer

Biomarker

Prognostic value

Clinical survival

Tumor stage

Differentiation grade

Metastasis

Response to chemotherapy

Response to immunotherapy

MAGE-A11

− [63]

N/A

N/A

+ [63]

N/A

N/A

NY-ESO-1

N/A

N/A

N/A

N/A

N/A

Vaccination:− [24]

TMB

N/A

N/A

N/A

N/A

N/A

PD-1 inhibition: + [18]

MANA

N/A

N/A

N/A

N/A

N/A

PD-1 inhibition: + [18]

PD-L1

N/A

N/A

N/A

N/A

N/A

PD-1 inhibition: + [18]

PD-1

N/A

+ [67]

N/A

+ [67]

N/A

N/A

CTLA-4

− [28]

N/A

N/A

N/A

N/A

N/A

IDO1

− [32, 70]

N/A

N/A

N/A

− [68]

N/A

PD-L1 + IDO1

− [68, 69]

N/A

N/A

N/A

− [69]

N/A

VISTA

+ [27]

N/A

N/A

N/A

N/A

N/A

TGF-β

N/A

N/A

N/A

N/A

− [72]

N/A

TGF-β + IL-10

N/A

+ [71]

N/A

N/A

N/A

N/A

IL-6

N/A

N/A

N/A

N/A

− [50]

N/A

CD80 or CD86

N/A

− [71, 73]

− [71, 73]

N/A

N/A

N/A

CD1a+ cells

N/A

N/A

− [73]

N/A

N/A

N/A

CD8+ TILs

+ [75]

N/A

N/A

− [75]

+ [75]

N/A

CD8+/Foxp3+ ratio

+ [29]

N/A

N/A

N/A

N/A

N/A

CCL4highCCL20low

+ [52]

N/A

N/A

N/A

N/A

N/A

M2-like TAMs

− [48, 49]

N/A

N/A

N/A

N/A

N/A

MDSCs

N/A

+ [50, 51]

N/A

N/A

− [50]

N/A

  1. +, positively correlated; −, negatively correlated; N/A not available
  2. EC esophageal cancer, MAGE-A11 melanoma-associated antigen A11, NY-ESO-1 New York esophageal squamous cell carcinoma 1, TMB tumor mutation burden, MANA mutation-associated neoantigen, PD-L1 programmed death-ligand 1, PD-1 programmed cell death protein 1, CTLA-4 cytotoxic T lymphocyte-associated protein 4, IDO1 indoleamine 2,3-dioxygenase 1, TGF-β transforming growth factor-β, IL-10 interleukin-10, IL-6 interleukin-6, TILs tumor-infiltrating lymphocytes, TAM tumor-associated macrophage, MDSC myeloid-derived suppressor cell