Timepoint | Enrollment | Treatment | Follow-up (months) | Close-out (months) | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Day 0 | Preoperative RT Day 1 | Resection Days 2–7 | Postoperative Days 1–2 | Postoperative Days 3–5 | 1,5 | 3 | 6 | 9 | 12 | |
Enrollment | ||||||||||
 Eligibility screening | X |  |  |  |  |  |  |  |  |  |
 Informed consent | X |  |  |  |  |  |  |  |  |  |
 Study visit | X | X |  |  | X | X | X | X | X | X |
 Planning CT | Within 1–7 days after enrollment |  |  |  |  |  |  |  |  |  |
 Planning MRI | Within 1–7 days after enrollment |  |  |  |  |  |  |  |  |  |
Interventions | ||||||||||
 Neoadjuvant SRS |  | X |  |  |  |  |  |  |  |  |
 Resection |  |  | X |  |  |  |  |  |  |  |
Assessments | ||||||||||
 MRI | X |  |  | X |  | X | X | X | X | X |
 Clinical-neurological examination | X | X | X | X | X | X | X | X | X | X |
 Minimental state examination | X |  |  |  |  | X | X | X | X | X |
 Health-related QoL | X |  |  |  | X | X | X | X | X | X |
 Toxicities | X |  |  |  | X | X | X | X | X | X |
 Adverse events |  | Continuous assessment | X | X | X | X | X |