Neoadjuvant stereotactic radiosurgery for intracerebral metastases of solid tumors (NepoMUC): a phase I dose escalation trial

Table 2 Time schedule of this study

Timepoint	Enrollment	Treatment				Follow-up (months)				Close-out (months)
Timepoint	Day 0	Preoperative RT Day 1	Resection Days 2–7	Postoperative Days 1–2	Postoperative Days 3–5	1,5	3	6	9	12
Enrollment
Eligibility screening	X
Informed consent	X
Study visit	X	X			X	X	X	X	X	X
Planning CT	Within 1–7 days after enrollment
Planning MRI	Within 1–7 days after enrollment
Interventions
Neoadjuvant SRS		X
Resection			X
Assessments
MRI	X			X		X	X	X	X	X
Clinical-neurological examination	X	X	X	X	X	X	X	X	X	X
Minimental state examination	X					X	X	X	X	X
Health-related QoL	X				X	X	X	X	X	X
Toxicities	X				X	X	X	X	X	X
Adverse events		Continuous assessment				X	X	X	X	X

This table of study schedule is based on the the SPIRIT© checklist, minor changes were made for adaption to the NepoMUC protocol
CT computer tomography, MRI magnetic resonance tomography, SRS stereotactic radiosurgery

ISSN: 2523-3548