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Table 2 Time schedule of this study

From: Neoadjuvant stereotactic radiosurgery for intracerebral metastases of solid tumors (NepoMUC): a phase I dose escalation trial

TimepointEnrollmentTreatmentFollow-up (months)Close-out (months)
Day 0Preoperative RT
Day 1
Days 2–7
Postoperative Days 1–2Postoperative Days 3–51,536912
 Eligibility screeningX         
 Informed consentX         
 Study visitXX  XXXXXX
 Planning CTWithin 1–7 days after enrollment         
 Planning MRIWithin 1–7 days after enrollment         
 Neoadjuvant SRS X        
 Resection  X       
 Clinical-neurological examinationXXXXXXXXXX
 Minimental state examinationX    XXXXX
 Health-related QoLX   XXXXXX
 ToxicitiesX   XXXXXX
 Adverse events Continuous assessmentXXXXX
  1. This table of study schedule is based on the the SPIRIT© checklist, minor changes were made for adaption to the NepoMUC protocol
  2. CT computer tomography, MRI magnetic resonance tomography, SRS stereotactic radiosurgery