Cohort | SRS dose level (Gy) |
|---|
I | II | III |
|---|
Lesion of ≤ 1.0 cm | 18 | 20 | 22 |
Lesion of 1.1–2.5 cm | 16 | 18 | 20 |
Lesion of 2.6–3.0 cm | 14 | 16 | 18 |
Lesion of 3.1–4.0 cm | 12 | 14 | 16 |
- The patients will be assigned to 4 different cohorts depending on the largest diameter of the intracerebral metastases to be radiosurgically treated before surgical removal. Each cohort has 3 dose levels. Size and dose were chosen according to the recommondations of the German Society of Radiation Oncology (DEGRO) working group on SRS for intracerebral metastases. The first 3 patients in the first cohort will be treated at a starting dose. If no dose-limiting toxicity (DLT) occurs in that dose level, the following 3 patients will be treated at the next higher dose level; if any of the first 3 patients experiences a DLT, the following 3 patients will be treated at the same dose level. At the highest dose level, at least 6 patients will be treated. Dose will be prescribed to the 80% isodose for linear accelerator (LINAC)-based radiotherapy
- SRS stereotactic radiosurgery
