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Table 3 Comparison of postoperative outcomes between PDAC patients in the OPD and LPD groups

From: Laparoscopic versus open pancreaticoduodenectomy for pancreatic ductal adenocarcinoma: a propensity score matching analysis

Characteristic Original cohort P Matched cohort P
OPD group
(n = 230)
LPD group
(n = 79)
OPD group
(n = 93)
LPD group
(n = 55)
POPF [cases (%)] 86 (37.4) 20 (25.3) 0.051 33 (35.5) 13 (23.6) 0.132
 Biochemical leak 74 (32.2) 13 (16.5) 0.007 28 (30.1) 9 (16.4) 0.062
 Grade B/C 12 (5.2) 7 (8.9) 0.373 5 (5.4) 4 (7.3) 0.912
DGE [cases (%)] 66 (28.7) 1 (1.3) < 0.001 34 (36.6) 1 (1.8) < 0.001
 Grade A 27 (11.7) 0 (0.0) 0.001 13 (14.0) 0 (0.0) 0.009
 Grade B/C 39 (17.0) 1 (1.3) < 0.001 21 (22.6) 1 (1.8) 0.001
PPH [cases (%)] 14 (6.1) 6 (7.6) 0.638 10 (10.8) 4 (7.3) 0.485
 Grade A 5 (2.2) 1 (1.3) 0.974 4 (4.3) 0 (0.0) 0.301
 Grade B/C 9 (3.9) 5 (6.3) 0.564 6 (6.5) 4 (7.3) 1.000
BL [cases (%)] 15 (6.5) 6 (7.6) 0.744 5 (5.4) 6 (10.9) 0.360
 Grade A 5 (2.2) 0 (0.0) 0.421 2 (2.2) 0 (0.0) 0.530a
 Grade B/C 10 (4.3) 6 (7.6) 0.407 3 (3.2) 6 (10.9) 0.125
Intra-abdominal infection [cases (%)] 21 (9.1) 4 (5.1) 0.253 12 (12.9) 2 (3.6) 0.063
Wound infection [cases (%)] 3 (1.3) 4 (5.1) 0.134 0 (0.0) 2 (3.6) 0.137a
Other complications [cases (%)] 24 (10.4) 8 (10.1) 0.938 11 (11.8) 6 (10.9) 0.865
Overall complications [cases (%)] 151 (65.7) 39 (49.4) 0.010 66 (71.0) 27 (49.1) 0.008
 Clavien I–II 133 (57.8) 30 (38.0) 0.002 53 (57.0) 21 (38.2) 0.027
 Clavien III–V 18 (7.8) 9 (11.4) 0.333 13 (14.0) 6 (10.9) 0.590
DSA [cases (%)] 7 (3.0) 5 (6.3) 0.334 5 (5.4) 4 (7.3) 0.912
Reoperation [cases (%)] 3 (1.3) 5 (6.3) 0.044 1 (1.1) 2 (3.6) 0.642
In-hospital mortality [cases (%)] 2 (0.9) 1 (1.3) 1.000a 2 (2.2) 0 (0.0) 0.530a
Readmission [cases (%)] 32 (13.9) 8 (10.1) 0.387 14 (15.1) 6 (10.9) 0.476
Postoperative length of stay [days, median (IQR)] 13.0 (10.0–19.0) 12.0 (10.0–18.0) 0.947 14.0 (10.0–20.0) 13.0 (11.0–20.0) 0.986
Time to adjuvant chemotherapy [days, median (IQR)] 44.0 (33.8–63.0) 39.0 (32.0–77.0) 0.616 43.5 (32.8–57.3) 39.0 (32.5–81.0) 0.935
  1. PDAC pancreatic ductal adenocarcinoma, OPD open pancreaticoduodenectomy, LPD laparoscopic pancreaticoduodenectomy, POPF postoperative pancreatic fistula, DGE delayed gastric emptying, PPH post-pancreatectomy hemorrhage, BL bile leakage, DSA digital subtraction angiography, IQR interquartile range
  2. aFisher’s exact test