Chromosome band 11q23 deletion predicts poor prognosis in bone marrow metastatic neuroblastoma patients without MYCN amplification

Table 3 Univariate and multivariate analysis of event-free survival (EFS) of children with bone marrow metastatic neuroblastoma

Variable	Total patients (n = 101)				Patients without MYCN amplification (n = 89)
	Univariate*	Multivariate^#			Univariate*	Multivariate^#
	P	HR	95% CI	P	P	HR	95% CI	P
MYCN status (amplification vs. normal)	< 0.001	2.399	1.113–5.169	0.032	–	–	–	–
LDH (≥ 1500 vs. < 1500 IU/L)	< 0.001	1.543	0.622–3.83	0.351	0.040	1.488	0.564–3.926	0.422
NSE (≥ 370 vs. < 370 ng/mL)	0.001	1.829	0.972–3.44	0.068	0.025	2.016	1.074–3.784	0.033
11q23 status (deletion vs. normal)	0.153	–	–	–	0.037	1.674	0.869–3.225	0.124

MYCN the v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog; LDH, lactate dehydrogenase, NSE neuron-specific enolase, HR hazard ratio, CI confidence interval
* Univariate analysis for EFS was performed using the Kaplan–Meier log-rank test. All factors with P < 0.05 in the univariate analysis are shown
^#All factors with P < 0.05 in the univariate analysis were selected in the backward Cox regression model for multivariate analysis of EFS

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