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Table 3 Univariate and multivariate analysis of event-free survival (EFS) of children with bone marrow metastatic neuroblastoma

From: Chromosome band 11q23 deletion predicts poor prognosis in bone marrow metastatic neuroblastoma patients without MYCN amplification

Variable Total patients (n = 101) Patients without MYCN amplification (n = 89)
Univariate* Multivariate# Univariate* Multivariate#
P HR 95% CI P P HR 95% CI P
MYCN status (amplification vs. normal) < 0.001 2.399 1.113–5.169 0.032
LDH (≥ 1500 vs. < 1500 IU/L) < 0.001 1.543 0.622–3.83 0.351 0.040 1.488 0.564–3.926 0.422
NSE (≥ 370 vs. < 370 ng/mL) 0.001 1.829 0.972–3.44 0.068 0.025 2.016 1.074–3.784 0.033
11q23 status (deletion vs. normal) 0.153 0.037 1.674 0.869–3.225 0.124
  1. MYCN the v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog; LDH, lactate dehydrogenase, NSE neuron-specific enolase, HR hazard ratio, CI confidence interval
  2. * Univariate analysis for EFS was performed using the Kaplan–Meier log-rank test. All factors with P < 0.05 in the univariate analysis are shown
  3. #All factors with P < 0.05 in the univariate analysis were selected in the backward Cox regression model for multivariate analysis of EFS