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Table 1 Changes of primary tumor in patients with renal cell carcinoma before and at 12 weeks after neoadjuvant therapy

From: Comparison of efficacy and safety among axitinib, sunitinib, and sorafenib as neoadjuvant therapy for renal cell carcinoma: a retrospective study

Variable

Axitinib

Sunitinib

Sorafenib

P 1

P 2

P 3

Maximal diameter (cm)a

 Before therapy

7.2 (6.2–8.5)

6.4 (5.7–10.3)

6.8 (5.8–11.0)

0.497

0.664

0.868

 After therapy

5.2 (4.4–7.4)

5.6 (5.1–9.8)

6.4 (4.8–6.4)

0.266

0.284

0.657

 Reduction

1.5 (1.2–2.2)

0.8 (0.5–1.1)

0.5 (0.4–0.8)

0.001

< 0.001

0.024

Reduction rate (%)a

22.4 (13.8–30)

12.2 (7.1–14.1)

6.9 (3.7–12.0)

0.001

0.001

0.023

> 10% reduction [cases (%)]

13 (86.7)

16 (66.7)

8 (26.7)

0.310*

0.001*

0.003*

  1. P1, axitinib vs. sunitinib; P2, axitinib vs. sorafenib; P3, sunitinib vs. sorafenib
  2. P, Wilcoxon signed-rank test; P*, Pearson’s Chi square test
  3. aThe data are presented as median (interquartile range)