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Table 4 First-line immunochemotherapy for marginal zone lymphoma

From: Phase II study of R–CVP followed by rituximab maintenance therapy for patients with advanced marginal zone lymphoma: consortium for improving survival of lymphoma (CISL) study

Study

Regimen

Disease type

Trial phase type

No. of patients

Overall RR (CR + PR)

PFS

OS

Salar et al. [19]

R-fludarabine

Any stage MALT lymphoma

II

22

100% (62 + 38)

2-year, 88%

2-year, 100%

Zucca et al. [23, 25]

R–Cb

Any stage MALT lymphoma

III (R–Cb vs R vs Cb)

132 (total 401)

94.7% (78.8 + 15.9)

5-year, 68%a

5-year, 90%

Kang et al. [24]

R–CVP

Stage III/IV MZL

II

41

87.5% (60 + 27.5)

3-year, 59%

3-year, 94%

Salar et al. [26, 27]

R–B

Any stage MALT lymphoma

II

57

100%

7-year, 92.8%

7-year, 94.7%

Oh (present study)

R–CVP followed by R-maintenance

Stage III/IV MZL

II

45

3-year, 81%

3-year, 90%

  1. PFS progression-free survival, OS overall survival, CR complete response, PR partial response, MZL marginal zone B-cell lymphoma, MALT mucosa-associated lymphoid tissue, R–CVP rituximab-cyclophosphamide, vincristine, and prednisolone, R–Cb rituximab–chlorambucil, R–B rituximab–bendamustine
  2. aEvent-free survival