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Table 5 Univariate analyses of prognostic factors for disease-free survival and overall survival in patients with stage III colon cancer who received curative treatment

From: Safety and efficacy of a modified XELOX adjuvant regimen for patients with operated stage III colon cancer: a Chinese single-center experience

Variables

Disease-free survival

Overall survival

HR (95% CI)

P value

HR (95% CI)

P value

Age, year (> 60 vs. ≤ 60))

1.702

(1.057–2.702)

0.026

1.465

(0.778–2.758)

0.237

Gender (male vs. female)

1.891

(1.132–3.159)

0.015

1.877

(0.954–3.693)

0.068

BMI, kg/m2 (< 18.5 vs. ≥ 18.5)

1.725

(0.538–5.527)

0.036

0.775

(0.274–2.191)

0.630

Tumor size, cm (> 4 vs. ≤ 4)

0.781

(0.483–1.264)

0.314

0.962

(0.516–1.794)

0.902

Tumor location

(right-sided colon vs. left-sided colon)

0.798

(0.496–1.285)

0.353

0.400

(0.213–1.754)

0.557

Differentiation

(poor vs. well/moderately differentiated)

1.354

(0.815–2.248)

0.242

1.245

(0.632–2.451)

0.527

T stage (T4 vs. T1–3)

1.446

(0.895–2.337)

0.132

2.311

(1.170–4.564)

0.016

Numbers of resected lymph nodes

(< 12 vs. ≥ 12)

1.356

(0.817–2.250)

0.239

0.938

(0.458–1.919)

0.860

N stage (N2 vs. N1)

1.334

(0.813–2.190)

0.225

1.817

(0.971–3.403)

0.062

Preoperative serum CEA, ng/mL

(> 5 vs. ≤ 5)

1.721

(1.072–2.760)

0.024

1.104

(0.590–2.067)

0.757

Preoperative serum CA19-9, U/mL

(> 24 vs. ≤ 24)

2.674

(1.667–4.288)

< 0.001

2.216

(1.190–4.124)

0.012

Risk stratification (high vs. l ow)

1.262

(0.764–2.086)

0.363

2.441

(1.122–5.313)

0.024

Adjuvant chemotherapy

(unfinished XELOX vs. modified XELOX)

1.668

(1.010–3.057)

0.043

3.256

(1.305–8.126)

0.011

Adjuvant chemotherapy

(standard XELOX vs. modified XELOX)

0.935

(0.489–1.785)

0.838

0.551

(0.207–1.468)

0.233

  1. XELOX oxaliplatin, and capecitabine regimen, BMI body mass index, CEA carcinoembryonic antigen, CA19-9 carbohydrate antigen 19-9, HR hazard ratio, CI confidence interval
  2. Right-sided colon cancer included the cecum, ascending colon, hepatic flexure, and transverse colon cancer, whereas left-sided colon cancer included the splenic flexure, descending colon, and sigmoid colon cancer