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Fig. 2 | Cancer Communications

Fig. 2

From: Impaired dendritic cell functions in lung cancer: a review of recent advances and future perspectives

Fig. 2

Peritumoral pDCs contribute to lung tumor progression. Impaired type I IFN secretion may faciliate tumor escape. CD33 and PD-L1 are upregulated in pDCs and contribute to immunosuppression. Lung tumors can activate AIM2 and inhibit CCR5 to construct a tumor-supportive microenvironment. pDC: plasmacytoid DC; cDC: conventional DC; NK: natural killer; IFN: interferon; CCR5: C–C chemokine receptor type 5; TLR: toll-like receptor; AIM2: melanoma 2; PD-L1: programmed cell death 1 ligand 1; IL-1α: interleukin 1α

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Cancer Communications

ISSN: 2523-3548

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