Fig. 2

mRNA expression correlation analysis of PD-L1 and PD-L2 in GTEx lung dataset and TCGA datasets (LUAD and LUSC) reveals major differences in mRNA expression profiles. a–c Expression correlation between PD-L1, PD-L2 and mRNA for cognate receptors CD80, PD-1, and RGMB in normal lung tissue from GTEx lung (n = 387) a, TCGA dataset LUAD (n = 706) b, and TCGA dataset LUSC (n = 626) c using Xena portal data. Spearman and Pearson correlation coefficients r and their corresponding P values are shown. The horizontal lines show the pairwise comparison of genes and line thickness is proportional to the degree of expression correlation. Dashed lines indicate negative expression correlation. Significant expression correlation is indicated in red. d, e Venn diagrams illustrating the number of genes expression correlated with PD-L1, PD-L2, and both, in TCGA dataset LUAD (n = 517) d, and LUSC (n = 501) e, using cBioPortal. For all panels, the criteria for significant expression correlation were Pearson correlation coefficient r ≥ 0.3 or ≤ − 0.3, Spearman correlation coefficient r ≥ 0.4 or ≤ − 0.4, and P values < 0.05. Pe Pearson, r correlation coefficient, Sp Spearman