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Table 2 Multivariate analyses of factors associated with 5-year overall survival for the 8th AJCC pN, LNR and N′ classifications

From: A homogenized approach to classify advanced gastric cancer patients with limited and adequate number of pathologically examined lymph nodes

Characteristics Multivariate analysis 1a   Multivariate analysis 2b   Multivariate analysis 3c
HR 95% CI P value HR 95% CI P value HR 95% CI P value
Age (years)
 ≤ 60 Ref.     Ref.     Ref.   
 > 60 1.404 1.226–1.607 < 0.001   1.392 1.216–1.592 < 0.001   1.401 1.225–1.604 < 0.001
Tumor location
 Lower 1/3 Ref.     Ref.     Ref.   
 Middle 1/3 1.264 1.006–1.590 0.045   1.259 1.000–1.586 0.050   1.268 1.009–1.593 0.042
 Upper 1/3 1.666 1.406–1.973 < 0.001   1.551 1.309–1.837 < 0.001   1.691 1.432–1.997 < 0.001
 Stomach > 1/3 1.737 1.233–2.446 0.002   1.735 1.231–2.446 0.002   1.738 1.235–2.445 0.002
Lauren type
 Intestinal Ref.     Ref.     Ref.   
 Diffuse 1.229 1.057–1.430 0.007   1.236 1.063–1.438 0.006   1.222 1.051–1.421 0.009
Gastrectomy
 Partial Ref.     Ref.     Ref.   
 Total 1.262 1.024–1.556 0.029   1.339 1.085–1.652 0.007   1.231 1.000–1.525 0.050
Examined LNs
 < 16 Ref.     Ref.     Ref.   
 ≥ 16 0.543 0.464–0.636 < 0.001   0.861 0.746–0.994 0.041   NA# NA# 0.374
8th AJCC pT classification
 T2 Ref.     Ref.     Ref.   
 T3 1.428 1.020–2.000 0.038   1.467 1.047–2.055 0.026   1.439 1.028–2.015 0.034
 T4a 2.063 1.524–2.793 < 0.001   2.094 1.546–2.835 < 0.001   2.064 1.524–2.794 < 0.001
 T4b 2.648 1.873–3.745 < 0.001   2.663 1.883–3.765 < 0.001   2.654 1.878–3.751 < 0.001
8th AJCC pN classification LNR classification     N′ classification    
 N0 Ref.    LNR 1 Ref.    N′0 Ref.   
 N1 2.044 1.587–2.633 < 0.001 LNR 2 1.703 1.256–2.309 0.001 N′1 2.142 1.491–3.076 < 0.001
 N2 3.328 2.638–4.198 < 0.001 LNR 3 2.717 2.142–3.446 < 0.001 N′2 3.746 2.650–5.295 < 0.001
 N3a 5.874 4.629–7.455 < 0.001 LNR 4 3.861 3.042–4.900 < 0.001 N′3a 6.078 4.344–8.503 < 0.001
 N3b 9.985 6.810–11.854 < 0.001 LNR 5 6.344 5.068–7.940 < 0.001 N′3b 10.419 7.373–14.724 < 0.001
  1. HR hazard ratio, CI confidence interval, LNs lymph nodes, AJCC American Joint Committee on Cancer, pT pathological tumor depth classification, pN pathological nodal classification, LNR lymph node ratio, N′ pathological modified nodal classification, Ref. reference; NA not available
  2. aMultivariate analysis 1: Clinicopathological factors showing significance in univariate analysis and the 8th AJCC pN classification, excluding the LNR classification and the N′ classification
  3. bMultivariate analysis 2: Clinicopathological factors showing significance in univariate analysis and the LNR classification, excluding the 8th AJCC pN classification and the N′ classification
  4. cMultivariate analysis 3: Clinicopathological factors showing significance in univariate analysis and the stages of the N′ classification, excluding the 8th AJCC pN classification and the LNR classification
  5. #NA: P > 0.05, the corresponding HR and 95% CI values were not available