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Table 2 Multivariate analyses of factors associated with 5-year overall survival for the 8th AJCC pN, LNR and N′ classifications

From: A homogenized approach to classify advanced gastric cancer patients with limited and adequate number of pathologically examined lymph nodes

Characteristics

Multivariate analysis 1a

 

Multivariate analysis 2b

 

Multivariate analysis 3c

HR

95% CI

P value

HR

95% CI

P value

HR

95% CI

P value

Age (years)

 ≤ 60

Ref.

   

Ref.

   

Ref.

  

 > 60

1.404

1.226–1.607

< 0.001

 

1.392

1.216–1.592

< 0.001

 

1.401

1.225–1.604

< 0.001

Tumor location

 Lower 1/3

Ref.

   

Ref.

   

Ref.

  

 Middle 1/3

1.264

1.006–1.590

0.045

 

1.259

1.000–1.586

0.050

 

1.268

1.009–1.593

0.042

 Upper 1/3

1.666

1.406–1.973

< 0.001

 

1.551

1.309–1.837

< 0.001

 

1.691

1.432–1.997

< 0.001

 Stomach > 1/3

1.737

1.233–2.446

0.002

 

1.735

1.231–2.446

0.002

 

1.738

1.235–2.445

0.002

Lauren type

 Intestinal

Ref.

   

Ref.

   

Ref.

  

 Diffuse

1.229

1.057–1.430

0.007

 

1.236

1.063–1.438

0.006

 

1.222

1.051–1.421

0.009

Gastrectomy

 Partial

Ref.

   

Ref.

   

Ref.

  

 Total

1.262

1.024–1.556

0.029

 

1.339

1.085–1.652

0.007

 

1.231

1.000–1.525

0.050

Examined LNs

 < 16

Ref.

   

Ref.

   

Ref.

  

 ≥ 16

0.543

0.464–0.636

< 0.001

 

0.861

0.746–0.994

0.041

 

NA#

NA#

0.374

8th AJCC pT classification

 T2

Ref.

   

Ref.

   

Ref.

  

 T3

1.428

1.020–2.000

0.038

 

1.467

1.047–2.055

0.026

 

1.439

1.028–2.015

0.034

 T4a

2.063

1.524–2.793

< 0.001

 

2.094

1.546–2.835

< 0.001

 

2.064

1.524–2.794

< 0.001

 T4b

2.648

1.873–3.745

< 0.001

 

2.663

1.883–3.765

< 0.001

 

2.654

1.878–3.751

< 0.001

8th AJCC pN classification

LNR classification

   

N′ classification

   

 N0

Ref.

  

LNR 1

Ref.

  

N′0

Ref.

  

 N1

2.044

1.587–2.633

< 0.001

LNR 2

1.703

1.256–2.309

0.001

N′1

2.142

1.491–3.076

< 0.001

 N2

3.328

2.638–4.198

< 0.001

LNR 3

2.717

2.142–3.446

< 0.001

N′2

3.746

2.650–5.295

< 0.001

 N3a

5.874

4.629–7.455

< 0.001

LNR 4

3.861

3.042–4.900

< 0.001

N′3a

6.078

4.344–8.503

< 0.001

 N3b

9.985

6.810–11.854

< 0.001

LNR 5

6.344

5.068–7.940

< 0.001

N′3b

10.419

7.373–14.724

< 0.001

  1. HR hazard ratio, CI confidence interval, LNs lymph nodes, AJCC American Joint Committee on Cancer, pT pathological tumor depth classification, pN pathological nodal classification, LNR lymph node ratio, N′ pathological modified nodal classification, Ref. reference; NA not available
  2. aMultivariate analysis 1: Clinicopathological factors showing significance in univariate analysis and the 8th AJCC pN classification, excluding the LNR classification and the N′ classification
  3. bMultivariate analysis 2: Clinicopathological factors showing significance in univariate analysis and the LNR classification, excluding the 8th AJCC pN classification and the N′ classification
  4. cMultivariate analysis 3: Clinicopathological factors showing significance in univariate analysis and the stages of the N′ classification, excluding the 8th AJCC pN classification and the LNR classification
  5. #NA: P > 0.05, the corresponding HR and 95% CI values were not available
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Cancer Communications

ISSN: 2523-3548

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