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Fig. 6 | Cancer Communications

Fig. 6

From: Metabolic reprogramming and redox adaptation in sorafenib-resistant leukemia cells: detected by untargeted metabolomics and stable isotope tracing analysis

Fig. 6

Metabolic rewiring of FLT3/ITD-mutated cells resistant to sorafenib. The resistant cells exhibit an increase in glycolytic activity, accompanied by a perturbed TCA cycle and inhibition of the pentose phosphate pathway, which may contribute to reduced proliferation of the resistant cells. GSH biosynthesis is increased in order to counteract the oxidative stress and to maintain a redox balance in a dynamic state. G6P glucose-6-phosphate, R5P ribose-5-phosphate, TCA tricarboxylic acid, GSH glutathione

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