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Table 1 Characteristics of 82 NPC patients with residual cervical lymphadenopathy

From: The diagnostic and prognostic values of plasma Epstein-Barr virus DNA for residual cervical lymphadenopathy in nasopharyngeal carcinoma patients: a retrospective study

Characteristic

Tumor cells in cervical lymph nodes [cases (%)]

P value

Presence

Absence

Total

68

14

 

Sex

  

0.045¶

 Male

52 (76.5)

7 (50.0)

 

 Female

16 (23.5)

7 (50.0)

 

Pathological type

  

0.133&

 WHO type II

2 (2.9)

2 (14.3)

 

 WHO type III

66 (97.1)

12 (85.7)

 

T stagea

  

0.334#

 T1

0 (0)

1 (7.1)

 

 T2

24 (35.3)

4 (28.6)

 

 T3

35 (51.5)

7 (50.0)

 

 T4

9 (13.2)

2 (14.3)

 

N stagea

  

0.974#

 N1

13 (19.1)

3 (21.4)

 

 N2

34 (50.0)

7 (50.0)

 

 N3

21 (30.9)

4 (28.6)

 

Clinical stagea

  

0.179¶

 II

7 (10.3)

4 (28.6)

 

 III

34 (50.0)

5 (35.7)

 

 IV

27 (39.7)

5 (35.7)

 

EBV DNA before treatment (copies/mL)

0.252¶

 ≤ 4000

23 (33.8)

7 (50.0)

 

 > 4000

45 (66.2)

7 (50.0)

 

EBV DNA before surgery (copy/mL) < 0.001#

 0

32 (47.1)

14 (100)

 

 > 0

36 (52.9)

0 (0.0)

 

VCA-IgA

  

0.988¶

 < 1:320

29 (42.6)

6 (42.9)

 

 ≥ 1:320

39 (57.4)

8 (57.1)

 

EA-IgA

  

0.196¶

 < 1:20

27 (39.7)

3 (21.4)

 

 ≥ 1:20

41 (60.3)

11 (78.6)

 

Size of lymph node 0.747¶

 < 3 cm

42 (61.8)

8 (57.1)

 

 ≥ 3 cm

26 (38.2)

6 (42.9)

 

Lymph node invasion 1.000#

 Yes

4 (5.9)

0 (0.0)

 

 No

64 (94.1)

14 (100)

 

Lymph node necrosis 0.865¶

 Yes

16 (23.5)

3 (21.4)

 

 No

52 (76.5)

11 (78.6)

 

Treatment for cervical lymphadenopathy

0.285#

 Surgery alone

54 (79.4)

14 (100)

 

 Surgery + chemotherapy

9 (13.2)

0 (0.0)

 

 Surgery + radiotherapy

5 (7.5)

0 (0.0)

 

Treatment for NPC

  

0.957#

 Radiotherapy alone

4 (5.9)

1 (7.15)

 

 CCRT

22 (32.4)

5 (35.7)

 

 NAC + CCRT

38 (55.9)

7 (50.0)

 

 CCRT + AC

4 (5.9)

1 (7.15)

 

Irradiation technique

  

1.000&

 2D-RT

7 (10.3)

1 (7.1)

 

 IMRT

61 (89.7)

13 (92.9)

 
  1. NPC nasopharyngeal carcinoma, WHO World Health Organization, EBV Epstein-Barr virus, VCA viral capsid antigen, IgA immunoglobulin A, EA early antigen, 2D-RT two-dimensional radiotherapy, IMRT intensity-modulated radiotherapy, CCRT concurrent chemoradiotherapy, NAC neoadjuvant chemotherapy, AC adjuvant chemotherapy
  2. P values were calculated with ¶the Chi square test, &Continuity Correlation, and #the Fisher’s exact test, respectively
  3. aThe 7th edition of American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) staging system was used