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Table 3 Univariate and multivariate associations of EGFR mutation and FISH status, clinicopathological characteristics, and status of other seven genes with PFS and OS in the 169 NSCLC patients with EGFR mutation

From: Identification of genetic alterations associated with primary resistance to EGFR-TKIs in advanced non-small-cell lung cancer patients with EGFR sensitive mutations

Variable PFS OS
Univariate Multivariate Univariate Multivariate
HR 95% CI P HR 95% CI P HR 95% CI P HR 95% CI P
Age
 ≤ 60 1       1      
 > 60 1.07 0.74–1.54 0.721     0.77 0.49–1.22 0.266    
Gender
 Male 1       1      
 Female 0.75 0.53–1.06 0.101     0.80 0.52–1.24 0.311    
Smoking status
 Smoking 1       1      
 No smoking 0.69 0.47–1.03 0.066     0.71 0.44–1.14 0.157    
Histology
 Non-ADC 1       1      
 ADC 0.84 0.47–1.49 0.539     0.75 0.37–1.52 0.424    
Differentiation
 High to medium 1       1      
 Low 0.81 0.57–1.15 0.237     0.93 0.60–1.44 0.751    
Stage
 Recurrent 1       1      
 IIIB and IV 0.91 0.63–1.32 0.628     0.92 0.59–1.45 0.730    
Line of TKI therapy
 2, 3 1       1      
 1 0.94 0.66–1.35 0.734     1.01 0.65–1.58 0.954    
ECOG PS
 2 1       1    1   
 0, 1 0.65 0.38–1.13 0.129     0.45 0.23-0.87 0.017 0.44 0.23-0.85 0.015
BIM
 Wt 1       1      
 Deletion 1.37 0.79-2.35 0.261     1.69 0.91–3.13 0.099    
PIK3CA mutation
 Wt 1       1      
 Mt 1.35 0.43–4.26 0.610     1.51 0.47–4.81 0.491    
PTEN copy number
 Intact 1    1.00    1      
 Deletion 3.64 1.47–9.00 0.005 4.29 1.72–10.72 0.002 2.86 1.04–7.89 0.042 2.97 1.07-8.20 0.036
PTEN expression
 Normal 1    1    1      
 Low expression 1.87 1.17-2.98 0.009 1.96 1.22–3.13 0.005 1.37 0.77–2.44 0.291    
MET copy number
 FISH− 1    1    1      
 FISH+ 2.69 1.30–5.54 0.008 2.83 1.37–5.86 0.005 1.31 0.57–3.01 0.529    
MET expression
 MAb− 1       1      
 MAb+ 1.02 0.68–1.55 0.913     0.67 0.36–1.25 0.213    
MET expression
 H-score− 1       1      
 H-score+ 1.36 0.95–1.95 0.692     1.24 0.79–1.96 0.348    
IGF1R copy number
 FISH− 1       1      
 FISH+ 0.35 0.05–2.48 0.291     1.14 0.16–8.32 0.893    
IGF1R expression
 IHC− 1       1      
 IHC+ 1.25 0.70–2.23 0.450     1.59 0.86–2.95 0.141    
  1. ADC adenocarcinoma, ECOG Eastern Cooperative Oncology group, TKI tyrosine kinase inhibitors, mt mutation, wt wild-type, FISH fluorescent in situ hybridization, HR hazard ratio, CI confidence interval