Variable
|
PFS
|
OS
|
---|
Univariate
|
Multivariate
|
Univariate
|
Multivariate
|
---|
HR
|
95% CI
|
P
|
HR
|
95% CI
|
P
|
HR
|
95% CI
|
P
|
HR
|
95% CI
|
P
|
---|
Age
|
≤ 60
|
1
| | | | | |
1
| | | | | |
> 60
|
1.07
|
0.74–1.54
|
0.721
| | | |
0.77
|
0.49–1.22
|
0.266
| | | |
Gender
|
Male
|
1
| | | | | |
1
| | | | | |
Female
|
0.75
|
0.53–1.06
|
0.101
| | | |
0.80
|
0.52–1.24
|
0.311
| | | |
Smoking status
|
Smoking
|
1
| | | | | |
1
| | | | | |
No smoking
|
0.69
|
0.47–1.03
|
0.066
| | | |
0.71
|
0.44–1.14
|
0.157
| | | |
Histology
|
Non-ADC
|
1
| | | | | |
1
| | | | | |
ADC
|
0.84
|
0.47–1.49
|
0.539
| | | |
0.75
|
0.37–1.52
|
0.424
| | | |
Differentiation
|
High to medium
|
1
| | | | | |
1
| | | | | |
Low
|
0.81
|
0.57–1.15
|
0.237
| | | |
0.93
|
0.60–1.44
|
0.751
| | | |
Stage
|
Recurrent
|
1
| | | | | |
1
| | | | | |
IIIB and IV
|
0.91
|
0.63–1.32
|
0.628
| | | |
0.92
|
0.59–1.45
|
0.730
| | | |
Line of TKI therapy
|
2, 3
|
1
| | | | | |
1
| | | | | |
1
|
0.94
|
0.66–1.35
|
0.734
| | | |
1.01
|
0.65–1.58
|
0.954
| | | |
ECOG PS
|
2
|
1
| | | | | |
1
| | |
1
| | |
0, 1
|
0.65
|
0.38–1.13
|
0.129
| | | |
0.45
|
0.23-0.87
|
0.017
|
0.44
|
0.23-0.85
|
0.015
|
BIM
|
Wt
|
1
| | | | | |
1
| | | | | |
Deletion
|
1.37
|
0.79-2.35
|
0.261
| | | |
1.69
|
0.91–3.13
|
0.099
| | | |
PIK3CA mutation
|
Wt
|
1
| | | | | |
1
| | | | | |
Mt
|
1.35
|
0.43–4.26
|
0.610
| | | |
1.51
|
0.47–4.81
|
0.491
| | | |
PTEN copy number
|
Intact
|
1
| | |
1.00
| | |
1
| | | | | |
Deletion
|
3.64
|
1.47–9.00
|
0.005
|
4.29
|
1.72–10.72
|
0.002
|
2.86
|
1.04–7.89
|
0.042
|
2.97
|
1.07-8.20
|
0.036
|
PTEN expression
|
Normal
|
1
| | |
1
| | |
1
| | | | | |
Low expression
|
1.87
|
1.17-2.98
|
0.009
|
1.96
|
1.22–3.13
|
0.005
|
1.37
|
0.77–2.44
|
0.291
| | | |
MET copy number
|
FISH−
|
1
| | |
1
| | |
1
| | | | | |
FISH+
|
2.69
|
1.30–5.54
|
0.008
|
2.83
|
1.37–5.86
|
0.005
|
1.31
|
0.57–3.01
|
0.529
| | | |
MET expression
|
MAb−
|
1
| | | | | |
1
| | | | | |
MAb+
|
1.02
|
0.68–1.55
|
0.913
| | | |
0.67
|
0.36–1.25
|
0.213
| | | |
MET expression
|
H-score−
|
1
| | | | | |
1
| | | | | |
H-score+
|
1.36
|
0.95–1.95
|
0.692
| | | |
1.24
|
0.79–1.96
|
0.348
| | | |
IGF1R copy number
|
FISH−
|
1
| | | | | |
1
| | | | | |
FISH+
|
0.35
|
0.05–2.48
|
0.291
| | | |
1.14
|
0.16–8.32
|
0.893
| | | |
IGF1R expression
|
IHC−
|
1
| | | | | |
1
| | | | | |
IHC+
|
1.25
|
0.70–2.23
|
0.450
| | | |
1.59
|
0.86–2.95
|
0.141
| | | |
- ADC adenocarcinoma, ECOG Eastern Cooperative Oncology group, TKI tyrosine kinase inhibitors, mt mutation, wt wild-type, FISH fluorescent in situ hybridization, HR hazard ratio, CI confidence interval