Table 3 Univariate and multivariate associations of EGFR mutation and FISH status, clinicopathological characteristics, and status of other seven genes with PFS and OS in the 169 NSCLC patients with EGFR mutation

Age

 ≤ 60

1

1

 > 60

1.07

0.74–1.54

0.77

0.49–1.22

Gender

 Male

1

1

 Female

0.75

0.53–1.06

0.80

0.52–1.24

Smoking status

 Smoking

1

1

 No smoking

0.69

0.47–1.03

0.71

0.44–1.14

Histology

 Non-ADC

1

1

 ADC

0.84

0.47–1.49

0.75

0.37–1.52

Differentiation

 High to medium

1

1

 Low

0.81

0.57–1.15

0.93

0.60–1.44

Stage

 Recurrent

1

1

 IIIB and IV

0.91

0.63–1.32

0.92

0.59–1.45

Line of TKI therapy

 2, 3

1

1

 1

0.94

0.66–1.35

1.01

0.65–1.58

ECOG PS

 2

1

1

1

 0, 1

0.65

0.38–1.13

0.45

0.23-0.87

0.44

0.23-0.85

BIM

 Wt

1

1

 Deletion

1.37

0.79-2.35

1.69

0.91–3.13

PIK3CA mutation

 Wt

1

1

 Mt

1.35

0.43–4.26

1.51

0.47–4.81

PTEN copy number

 Intact

1

1.00

1

 Deletion

3.64

1.47–9.00

4.29

1.72–10.72

2.86

1.04–7.89

2.97

1.07-8.20

PTEN expression

 Normal

1

1

1

 Low expression

1.87

1.17-2.98

1.96

1.22–3.13

1.37

0.77–2.44

MET copy number

 FISH−

1

1

1

 FISH+

2.69

1.30–5.54

2.83

1.37–5.86

1.31

0.57–3.01

MET expression

 MAb−

1

1

 MAb+

1.02

0.68–1.55

0.67

0.36–1.25

MET expression

 H-score−

1

1

 H-score+

1.36

0.95–1.95

1.24

0.79–1.96

IGF1R copy number

 FISH−

1

1

 FISH+

0.35

0.05–2.48

1.14

0.16–8.32

IGF1R expression

 IHC−

1

1

 IHC+

1.25

0.70–2.23

1.59

0.86–2.95