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Table 2 Univariate and multivariate associations of EGFR mutation and FISH status, clinicopathological characteristics, and status of other seven genes with PFS and OS in the total of 416 NSCLC patients

From: Identification of genetic alterations associated with primary resistance to EGFR-TKIs in advanced non-small-cell lung cancer patients with EGFR sensitive mutations

Variable PFS OS
Univariate Multivariate Univariate Multivariate
HR 95% CI P HR 95% CI P HR 95% CI P HR 95% CI P
Age
 ≤ 60 1       1      
 > 60 1.01 0.82–1.25 0.913     1.21 0.94–1.57 0.145    
Gender
 Male 1    1    1    1   
 Female 0.59 0.48–0.73 < 0.001 0.56 0.42–0.74 < 0.001 0.59 0.45–0.76 < 0.001 0.65 0.48–0.94 0.006
Smoking status
 Smoking 1    1    1    1   
 No smoking 0.60 0.48–0.74 < 0.001 0.64 0.50–0.81 < 0.001 0.62 0.48–0.80 < 0.001 0.79 0.58–1.06 0.113
Histology
 Non-ADC 1    1    1      
 ADC 0.67 0.52–0.86 0.002 0.84 0.64–1.10 0.203 0.78 0.58–1.07 0.122    
Differentiation
 High to medium 1    1    1      
 Low 1.36 1.11–1.68 0.004 0.89 0.72–1.18 0.299 1.12 0.87–1.44 0.363    
Stage
 Recurrent 1       1      
 IIIB and IV 0.88 0.70–1.10 0.254     0.83 0.63–1.09 0.183    
Line of TKI therapy
 2, 3 1    1    1    1   
 1 0.68 0.53–0.87 0.002 0.75 0.58–0.97 0.027 0.67 0.50–0.90 0.009 0.78 0.57–1.05 0.103
ECOG PS
 2 1    1    1    1   
 0, 1 0.71 0.52–0.95 0.023 0.73 0.54–0.99 0.043 1.71 1.17–2.48 0.004 0.62 0.43–0.90 0.011
EGFR mutation
 Mt 1    1    1    1   
 Wt 0.38 0.31–0.47 < 0.001 0.54 0.42–0.70 < 0.001 0.50 0.38–0.65 < 0.001 0.63 0.47–0.85 0.002
EGFR copy number
 FISH− 1    1    1    1   
 FISH+ 0.54 0.43–0.67 < 0.001 0.67 0.54–0.84 0.001 0.60 0.46–0.78 < 0.001 0.77 0.58–1.02 0.068
ALK
 Wt 1    1    1    1   
 Apart 2.06 1.41–3.02 < 0.001 1.41 0.93–2.16 0.105 1.59 1.00–2.51 0.047 1.34 0.82–2.17 0.240
BIM
 Wt 1       1      
 Deletion 0.89 0.58–1.36 0.596     1.05 0.64–1.71 0.856    
KRAS mutation
 Wt 1    1    1      
 Mt 1.99 1.33–2.99 0.001 1.21 0.79–1.84 0.386 1.55 0.97–2.47 0.070    
PIK3CA mutation
 wt 1       1      
 mt 1.18 0.61–2.29 0.619     1.22 0.60–2.47 0.583    
PTEN copy number
 Intact 1       1      
 Deletion 1.54 0.99–2.39 0.058     1.06 0.64–1.77 0.811    
PTEN expression
 Normal 1    1    1      
 Low expression 1.37 1.08–1.74 0.011 1.10 0.86–1.42 0.439 1.12 0.84–1.50 0.448    
MET copy number
 FISH− 1    1    1    1   
 FISH+ 1.87 1.35–2.60 < 0.001 1.51 1.07–2.13 0.019 1.64 1.14–2.37 0.008 1.47 1.01–2.13 0.045
MET expression
 MAb− 1       1      
 MAb+ 1.01 0.79–1.28 0.955     1.18 0.87–1.59 0.283    
MET expression
 H-score− 1       1      
 H-score+ 1.14 0.93–1.40 0.217     0.97 0.75–1.25 0.805    
IGF1R copy number
 FISH− 1    1    1      
 FISH+ 1.40 1.05–1.87 0.019 1.07 0.78–1.46 0.688 1.10 0.77–1.57 0.619    
IGF1R expression
 IHC− 1       1      
 IHC+ 1.26 0.99–1.61 0.062     1.05 0.78–1.40 0.770    
  1. ADC adenocarcinoma, ECOG Eastern cooperative oncology group, TKI tyrosine kinase inhibitors, FISH fluorescent in situ hybridization, HR hazard ratio, CI confidence interval, PFS progression-free survival, OS overall survival