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Table 1 Clinicopathological characteristics of 147 triple-negative breast cancer (TNBC) patients with normal or abnormal electrocardiography (ECG)

From: The association between early-onset cardiac events caused by neoadjuvant or adjuvant chemotherapy in triple-negative breast cancer patients and some novel autophagy-related polymorphisms in their genomic DNA: a real-world study

Characteristic Normal ECG group Abnormal ECG group P value
Total [cases (%)] 46 (31.3) 101 (68.7)
Age [years, median (range)] 51 (30–75) 50 (32–72) 0.731
Baseline heart rate [bpm, mean ± SD] 75.1 ± 10.7 75.3 ± 11.7 0.931
Disease-free survival [months, median (range)] 64.3 (7.7–183.2) 58.6 (3.6–181.7) 0.473
Hypertension [cases (%)] 5 (10.9) 17 (16.8) 0.490
Diabetes [cases (%)] 1 (2.2) 7 (6.9) 0.250
Smoking [cases (%)] 2 (4.3) 5 (5.0) 0.874
Excessive alcohol consumption [cases (%)] 1 (2.2) 16 (15.8) 0.034
Family history of heart disease [cases (%)] 4 (8.7) 7 (6.9) 0.969
Chemotherapy [cases (%)] 1.000
 Neoadjuvant 3 (6.5) 5 (5.0)  
 Adjuvant 43 (93.5) 96 (95.0)  
Drug uses [cases (%)]
 Anthracyclines 22 (47.8) 67 (66.3) 0.033
 Cyclophosphamide 24 (52.2) 57 (56.4) 0.630
 Paclitaxel 20 (43.5) 42 (41.6) 0.829
 Docetaxel 19 (41.3) 40 (39.6) 0.845
 Carboplatin 16 (34.8) 27 (26.7) 0.320
 5-Fluorouracil 1 (2.2) 4 (4.0) 0.949
Chemotherapy regimens [cases (%)] 0.242
 Anthracycline-based 6 (13.0) 16 (15.8)  
 Taxane-based 23 (50.0) 33 (32.7)  
 Anthracycline–taxane-based 16 (34.8) 50 (49.5)  
 Others 1 (2.2) 2 (2.0)  
  1. SD standard deviation