Table 3 Correlation between D-CEUS parameters and PFS and DMFS
Parameter changes | < 30% | ≥ 30% | P value |
|---|---|---|---|
3-year estimate (%, 95% CI) | |||
PFS (day 8) | |||
 Peak intensity | 90.9 (73.7–100) | 44.4 (11.9–76.9) | 0.021 |
 Area under the curve | 90.0 (71.4–100) | 50.0 (31.0–81.0) | 0.048 |
 Slope of wash-in (coefficient) | 90.9 (73.7–100) | 44.4 (11.9–76.9) | 0.021 |
 Wash-in perfusion index | 90.9 (73.7–100) | 44.4 (11.9–76.9) | 0.021 |
DMFS (day 8) | |||
 Peak intensity | 90.9 (73.7–100) | 55.6 (23.1–88.1) | 0.065 |
 Area under the curve | 90.0 (71.4–100) | 60.0 (23.1–88.2) | 0.119 |
 Slope of wash-in (coefficient) | 90.9 (73.7–100) | 55.6 (23.1–88.1) | 0.065 |
 Wash-in perfusion index | 90.9 (73.7–100) | 55.6 (23.1–88.1) | 0.065 |
PFS (day 15) | |||
 Peak intensity | 94.1 (82.9–100) | 0.0 | < 0.001 |
 Area under the curve | 92.3 (77.8–100) | 42.9 (6.2–79.6) | 0.038 |
 Slope of wash-in (coefficient) | 86.7 (69.5–100) | 20.0 (0–55.1) | 0.002 |
 Wash-in perfusion index | 80.0 (59.8–100) | 40.0 (0–82.9) | 0.072 |
DMFS (day 15) | |||
 Peak intensity | 88.2 (72.9–100) | 0.0 | < 0.001 |
 Area under the curve | 84.6 (65.0–100) | 57.1 (20.4–93.8) | 0.16 |
 Slope of wash-in (coefficient) | 93.3 (80.8–100) | 20.0 (0–55.1) | < 0.001 |
 Wash-in perfusion index | 86.7 (69.5–100) | 21.9 (0–82.9) | 0.024 |