|
Parameter changes
|
< 30%
|
≥ 30%
|
P value
|
|---|
|
3-year estimate (%, 95% CI)
|
|---|
|
PFS (day 8)
|
|
Peak intensity
|
90.9 (73.7–100)
|
44.4 (11.9–76.9)
|
0.021
|
|
Area under the curve
|
90.0 (71.4–100)
|
50.0 (31.0–81.0)
|
0.048
|
|
Slope of wash-in (coefficient)
|
90.9 (73.7–100)
|
44.4 (11.9–76.9)
|
0.021
|
|
Wash-in perfusion index
|
90.9 (73.7–100)
|
44.4 (11.9–76.9)
|
0.021
|
|
DMFS (day 8)
|
|
Peak intensity
|
90.9 (73.7–100)
|
55.6 (23.1–88.1)
|
0.065
|
|
Area under the curve
|
90.0 (71.4–100)
|
60.0 (23.1–88.2)
|
0.119
|
|
Slope of wash-in (coefficient)
|
90.9 (73.7–100)
|
55.6 (23.1–88.1)
|
0.065
|
|
Wash-in perfusion index
|
90.9 (73.7–100)
|
55.6 (23.1–88.1)
|
0.065
|
|
PFS (day 15)
|
|
Peak intensity
|
94.1 (82.9–100)
|
0.0
|
< 0.001
|
|
Area under the curve
|
92.3 (77.8–100)
|
42.9 (6.2–79.6)
|
0.038
|
|
Slope of wash-in (coefficient)
|
86.7 (69.5–100)
|
20.0 (0–55.1)
|
0.002
|
|
Wash-in perfusion index
|
80.0 (59.8–100)
|
40.0 (0–82.9)
|
0.072
|
|
DMFS (day 15)
|
|
Peak intensity
|
88.2 (72.9–100)
|
0.0
|
< 0.001
|
|
Area under the curve
|
84.6 (65.0–100)
|
57.1 (20.4–93.8)
|
0.16
|
|
Slope of wash-in (coefficient)
|
93.3 (80.8–100)
|
20.0 (0–55.1)
|
< 0.001
|
|
Wash-in perfusion index
|
86.7 (69.5–100)
|
21.9 (0–82.9)
|
0.024
|
- D-CEUS dynamic contrast enhanced ultrasound, PFS progression-free survival, DMFS Distant metastasis-free survival, CI confidence interval
