Fig. 6From: Snail promotes metastasis of nasopharyngeal carcinoma partly by down-regulating TEL2Snail promotes NPC metastasis to lung mostly by down-regulating TEL2 in a nude mouse model. a–c Stably transfected cells were injected into the lateral tail vein of nude mice. a Quantitation of the number of metastases. Data are mean ± SEM (n = 6 per group). b Macroscopic appearance of metastatic lung tumors. c Tumor cross sections with hemotoxylin-eosin staining. Scale bars in (c): 500 μm (left), 50 μm (right). d Proposed model for the regulation and function of TEL2 in NPC metastasis. Snail down-regulates TEL2 during exposure to normoxia or hypoxia, up-regulating SERPINE1, which promotes NPC metastasisBack to article page