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Fig. 6 | Cancer Communications

Fig. 6

From: Snail promotes metastasis of nasopharyngeal carcinoma partly by down-regulating TEL2

Fig. 6

Snail promotes NPC metastasis to lung mostly by down-regulating TEL2 in a nude mouse model. ac Stably transfected cells were injected into the lateral tail vein of nude mice. a Quantitation of the number of metastases. Data are mean ± SEM (n = 6 per group). b Macroscopic appearance of metastatic lung tumors. c Tumor cross sections with hemotoxylin-eosin staining. Scale bars in (c): 500 μm (left), 50 μm (right). d Proposed model for the regulation and function of TEL2 in NPC metastasis. Snail down-regulates TEL2 during exposure to normoxia or hypoxia, up-regulating SERPINE1, which promotes NPC metastasis

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