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Fig. 2 | Cancer Communications

Fig. 2

From: Snail promotes metastasis of nasopharyngeal carcinoma partly by down-regulating TEL2

Fig. 2

Snail binds directly to the TEL2 promoter in NPC cells. a Schematic illustration of the wild-type TEL2 promoter and its mutants in luciferase reporter assays. b, c S26 cells stably transfected with empty vector or Snail-encoding plasmid were transfected with a luciferase reporter plasmid in which luciferase expression was driven by the wild-type or mutant TEL2 promoter. Luciferase activity was measured as described in Methods. Data are mean ± SEM of triplicate samples. *P < 0.05, **P < 0.01. d Schematic illustration of the location of primers for ChIP analysis. e–g Cells were analyzed in ChIP assays using anti-Snail antibody as described in “Methods

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