Skip to main content

Table 1 Association between clinicopathologic factors and NS1-BP expression in esophageal squamous cell carcinoma (ESCC) patients

From: NS1-binding protein radiosensitizes esophageal squamous cell carcinoma by transcriptionally suppressing c-Myc

Variables Learning cohort [cases (%)] Validation cohort [cases (%)]
High expression Low expression P* High expression Low expression P*
Age (years) 0.775    0.547
 ≤ 55a 22 (40.7) 32 (59.3)   10 (40.0) 15 (60.0)  
 > 55 19 (43.1) 25 (56.9)   8 (38.0) 13 (62.0)  
Gender 0.501    0.709
 Male 34 (41.5) 48 (58.5)   15 (36.8) 23 (63.2)  
 Female 7 (43.8) 9 (56.2)   3 (37.5) 5 (62.5)  
WHO grade 0.719    0.660
 G1 11 (45.8) 13 (54.2)   4 (36.4) 7 (63.6)  
 G2 20 (40.0) 30 (60.0)   8 (40.0) 12 (60.0)  
 G3/4 10 (41.7) 14 (58.3)   6 (40.0) 9 (60.0)  
Tumor size (cm) 0.640    0.387
 ≤ 6b 22 (39.3) 34 (60.7)   13 (40.7) 19 (59.3)  
 > 6 19 (45.2) 23 (54.8)   5 (35.8) 9 (64.2)  
T category 0.541    0.174
 T2 5 (41.7) 7 (58.3)   6 (50.0) 6 (50.0)  
 T3 14 (40.0) 21 (60.0)   6 (33.3) 12 (66.7)  
 T4 22 (43.1) 29 (56.9)   6 (37.5) 10 (62.5)  
N category 0.622    0.328
 N0 8 (47.1) 9 (52.9)   6 (42.9) 8 (57.1)  
 N1 33 (40.8) 48 (59.2)   12 (37.5) 20 (62.5)  
M category 0.352    0.302
 M0 27 (45.8) 32 (54.2)   10 (41.7) 14 (58.3)  
 M1-lym 14 (35.9) 25 (64.1)   8 (31.9) 14 (68.1)  
CRT response 0.007    0.003
 CR 14 (73.7) 5 (26.3)   8 (80.0) 2 (20.0)  
 Not CR 27 (34.2) 52 (65.8)   10 (27.8) 26 (72.2)  
  1. ESCC esophageal squamous cell carcinoma, T tumor, N node, M metastases, M1-lym distant lymph node metastasis, CR complete response
  2. * χ2 test
  3. aMean age
  4. bMean tumor size