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Table 3 Summary of events that resulted in dose reductions and delays

From: Attenuated FOLFIRINOX in the salvage treatment of gemcitabine-refractory advanced pancreatic cancer: a phase II study

Toxicity Grade Oxaliplatin, 5-FU/Leucovorin Irinotecan
Hemoglobin Any grade No reduction
Neutropenia 3 (ANC 500–999/mm3) No reduction (1 week delay)
4 (ANC ≤ 499/mm3) 25% reduction 25% reduction
Febrile neutropenia 3 (ANC < 1000/mm3 and body temperature ≥ 38.5 °C) 25% reduction 25% reduction
4 (grade 3 febrile neutropenia and life threatening sepsis) 50% reduction 50% reduction
Thrombocytopenia 3 (25,000–50,000/mm3) 25% reduction 25% reduction
4 (< 25,000/mm3) 25% reduction
  1. ANC absolute neutrophil count