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Table 3 End of treatment and best overall response rate

From: Safety and efficacy of obinutuzumab in Chinese patients with B-cell lymphomas: a secondary analysis of the GERSHWIN trial

Variable CLL (n = 12) DLBCL (n = 23) FL (n = 13) Overall (n = 48)
EoT response Best overall response EoT response Best overall response EoT response Best overall response EoT response Best overall response
Responders, n (%) 7 (58.3) 9 (75.0) 3 (13.0) 6 (26.1) 6 (46.2) 8 (61.5) 16 (33.3) 23 (47.9)
Non-responders, n (%) 5 (41.7) 3 (25.0) 20 (87.0) 17 (73.9) 7 (53.8) 5 (38.5) 32 (66.7) 25 (52.1)
95% CI for response rate 27.67–84.83 42.81–94.51 2.78–33.59 10.23–48.41 19.22–74.87 31.58–86.14 20.40–48.41 33.29–62.81
CR, n 0 0 0 0 0 0 0 0
95% CI 0.00–26.46 0.00–26.46 0.00–14.82 0.00–14.82 0.00–24.71 0.00–24.71 0.00–7.40 0.00–7.40
CRi, n 0 0 0 0 0 0 0 0
95% CI 0.00–26.46 0.00–26.46 0.00–14.82 0.00–14.82 0.00–24.71 0.00–24.71 0.00–7.40 0.00–7.40
CRu, n (%) 0 0 1 (4.3) 1 (4.3) 0 0 1 (2.1) 1 (2.1)
95% CI 0.00–26.46 0.00–26.46 0.11–21.95 0.11–21.95 0.00–24.71 0.00–24.71 0.05–11.07 0.05–11.07
PR, n (%) 7 (58.3) 9 (75.0) 2 (8.7) 5 (21.7) 6 (46.2) 8 (61.5) 15 (31.3) 22 (45.8)
95% CI 27.67–84.83 42.81–94.51 1.07–28.04 7.46–43.70 19.22–74.87 31.58–86.14 18.66–46.25 31.37–60.83
SD, n (%) 1 (8.3) 1 (8.3) 2 (8.7) 6 (26.1) 4 (30.8) 4 (30.8) 7 (14.6) 11 (22.9)
95% CI 0.21–38.48 0.21–38.48 1.07–28.04 10.23–48.41 9.09–61.43 9.09–61.43 6.07–27.76 12.03–37.31
PD, n (%) 2 (16.7) 0 15 (65.2) 9 (39.1) 3 (23.1) 1 (7.7) 20 (41.7) 10 (20.8)
95% CI 2.09–48.41 0.00–26.46 42.73–83.62 19.71–61.46 5.04–53.81 0.19–36.03 27.61–56.79 10.47–34.99
Missing or non-evaluable, n (%) 2 (16.7) 2 (16.7) 3 (13.0) 2 (8.7) 0 0 5 (10.4) 4 (8.3)
  1. 95% CI for rates were constructed using Clopper–Pearson method. Patients were classified as missing or non-evaluable if no post-baseline response assessments were available or all post-baseline response baseline assessments were un-evaluable
  2. CLL chronic lymphocytic leukemia, CI confidence interval, CR complete response, CRi CR with incomplete bone marrow recovery (CRi; CLL patients only), CRu CR unconfirmed, DLBCL diffuse large B-cell lymphoma, EoT end of treatment, FL follicular lymphoma, PR partial response, SD stable disease