Table 4 Univariate and multivariate analyses of prognostic factors for overall survival in patients with MSKCC-CRS 3–5
Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
Age (≤ 60 years vs. > 60 years) | 0.945 (0.457–1.955) | 0.880 |  |  |
Sex (male vs. female) | 1.014 (0.492–2.090) | 0.970 |  |  |
Primary tumor location (rectum vs. colon) | 1.562 (0.754–3.236) | 0.230 |  |  |
Primary tumor differentiation (poor vs. well to moderate) | 1.601 (0.732–3.502) | 0.160 |  |  |
T stage (4 vs. 1–3) | 1.957 (0.964–3.973) | 0.063 | 2.247 (1.093–4.622) | 0.028 |
N stage (positive vs. negative) | 1.139 (0.345–3.760) | 0.831 |  |  |
Timing of metastasis (synchronous vs. metachronous) | 1.190 (0.456–3.106) | 0.722 |  |  |
Number of metastatic tumors (> 1 vs. 1) | 0.930 (0.279–3.095) | 0.906 |  |  |
Metastases diameter( > 3 cm vs. ≤ 3 cm) | 1.625 (0.795–3.321) | 0.183 |  |  |
Preoperative CEA (> 50 ng/mL vs. ≤ 50 ng/mL) | 0.727 (0.334–1.585) | 0.423 |  |  |
Preoperative CA19-9 (> 35 U/mL vs. ≤ 35 U/mL) | 0.972 (0.444–2.129) | 0.943 |  |  |
Preoperative chemotherapy (yes vs. no) | 1.470 (0.687–3.148) | 0.321 |  |  |
ACT (yes vs. no) | 0.402 (0.188–0.858) | 0.018 | 0.350 (0.161–0.759) | 0.008 |