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Fig. 4 | Cancer Communications

Fig. 4

From: Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer

Fig. 4

SLC7A11 regulation by transcriptional, post-transcriptional, and post-translational mechanisms. Cellular stresses, such as oxidative stress and amino acid starvation, induce SLC7A11 transcription through NRF2 and/or ATF4 transcription factors, whereas p53 represses SLC7A11 expression. SLC7A11 mRNA stability can be negatively regulated by either microRNAs or NMD. Oxidative stress relieves NMD-mediated degradation of SLC7A11 mRNA. mTORC2 phosphorylates SLC7A11 at serine 26, resulting in inhibition of SLC7A11 transport activity. NMD nonsense-mediated mRNA decay

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Cancer Communications

ISSN: 2523-3548

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