Skip to main content

Table 2 Combination index values of evofosfamide combined with cisplatin (DDP) in the HNE-1 cell line

From: Efficacy of the hypoxia-activated prodrug evofosfamide (TH-302) in nasopharyngeal carcinoma in vitro and in vivo

Normoxia

Hypoxia

Drug concentration (μmol/L)

CI

Drug concentration (μmol/L)

CI

DDP

Evofosfamide

DDP

Evofosfamide

0.62

6.2

0.899

0.62

0.06

0.737

1.25

12.5

1.077

1.25

0.13

0.915

2.5

25

0.885

2.5

0.25

0.840

5

50

0.430

5

0.5

0.556

10

100

0.182

10

1

0.442

  1. CI > 1 indicates an antagonistic effect; CI = 1 indicates an additive effect; CI < 1 indicates a synergistic effect
  2. CI combination index
Back to article page

Cancer Communications

ISSN: 2523-3548

Contact us