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Table 2 Combination index values of evofosfamide combined with cisplatin (DDP) in the HNE-1 cell line

From: Efficacy of the hypoxia-activated prodrug evofosfamide (TH-302) in nasopharyngeal carcinoma in vitro and in vivo

Normoxia Hypoxia
Drug concentration (μmol/L) CI Drug concentration (μmol/L) CI
DDP Evofosfamide DDP Evofosfamide
0.62 6.2 0.899 0.62 0.06 0.737
1.25 12.5 1.077 1.25 0.13 0.915
2.5 25 0.885 2.5 0.25 0.840
5 50 0.430 5 0.5 0.556
10 100 0.182 10 1 0.442
  1. CI > 1 indicates an antagonistic effect; CI = 1 indicates an additive effect; CI < 1 indicates a synergistic effect
  2. CI combination index