Fig. 2

Computed tomography (CT) scans and pathology for patient CTC15035_EML4–ALK with stage IV bronchogenic carcinoma and the patient-derived xenograft tumors. a Baseline CT chest scan on 2014-11-14 showed there was a nodule in the middle lobe of the right lung and a small amount pleural effusion in the lower lobe of the right lung. b After two gemcitabine plus carboplatin chemotherapy cycles, CT of disease progression on 2014-12-23 showed the pleural effusion increased significantly compared with that of baseline. c After 2 months of crizotinib targeted therapy, CT chest scan on 2015-3-12 showed the disease was stable and the pleural effusion decreased compared with that of pre-crizotinib treatment. Pathology was examined by H&E staining of the tumor biopsy from d patient CTC15035_EML4–ALK when pleural effusion increased significantly and, e a xenograft tumor from CTC15035_EML4–ALK. Histology of xenograft tumors was well-matched with those of primary tumors