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Table 4 Associations of macrophage inflammatory protein (MIP)-1α and MIP-1β serum levels with nasopharyngeal carcinoma (NPC) risk in the nested case–control study by the time interval between blood collection and diagnosis

From: Decreased macrophage inflammatory protein (MIP)-1α and MIP-1β increase the risk of developing nasopharyngeal carcinoma

Markera Cases diagnosed within 1 year after blood collection Cases diagnosed more than 1 year after blood collection
NPCs Controls OR1 (95% CI) OR2 (95% CI) OR3 (95% CI) NPCs Controls OR1 (95% CI) OR2 (95% CI) OR3 (95% CI)
MIP-1α
 Category 1 8 14 Reference Reference Reference 12 17 Reference Reference Reference
 Category 2 4 9 0.70 (0.18–2.81) 2.68 (0.20–35.6) 1.03 (0.14–7.60) 10 20 0.81 (0.28–2.36) 0.68 (0.18–2.61) 0.59 (0.15–2.37)
 Category 3 9 15 0.94 (0.21–4.18) 10.14 (0.58–177) 1.76 (0.33–9.51) 12 15 1.13 (0.36–3.54) 0.62 (0.12–3.29) 1.21 (0.31–4.70)
 Category 4 2 10 0.32 (0.05–1.86) 0.80 (0.06–10.2) 0.10 (0.01–2.39) 2 20 0.16 (0.03–0.81) 0.07 (0.01–0.82) 0.09 (0.01–0.82)
P trend    0.462 0.450 0.312    0.020 0.032 0.036
MIP-1β
 Category 1 6 13 Reference Reference Reference 15 17 Reference Reference Reference
 Category 2 7 13 1.16 (0.31–4.34) 1.28 (0.20–8.42) 1.79 (0.22–14.7) 10 17 0.72 (0.26–2.00) 0.41 (0.10–1.74) 0.38 (0.09–1.59)
 Category 3 7 14 1.08 (0.31–3.83) 1.23 (0.22–6.78) 1.62 (0.20–13.3) 7 14 0.64 (0.21–1.94) 0.32 (0.05–1.95) 0.30 (0.05–1.84)
 Category 4 4 8 1.09 (0.26–4.55) 0.83 (0.12–5.72) 0.96 (0.05–17.3) 4 23 0.21 (0.06–0.74) 0.08 (0.01–0.59) 0.12 (0.01–0.94)
P trend    0.953 0.860 0.919    0.013 0.016 0.047
  1. MIP-1α macrophage inflammatory protein-1 alpha, MIP-1β macrophage inflammatory protein-1 beta, NPC nasopharyngeal carcinoma, OR 1 odds ratio computed using logistic regression adjusted for gender and age, OR 2 computed using logistic regression adjusted for gender, age, and anti-Epstein-Barr virus nuclear antigen-1 immunoglobulin A antibody (EBNA1/IgA), OR 3 computed using logistic regression adjusted for gender, age, salted fish consumption, family history, and EBNA1/IgA, CI confidence interval, Category 1, 2, 3, and 4 markers were categorized into four groups based on the quartiles among controls, P trend computed using Wald statistic of regression model parameters for marker intracategory medians modeled as a continuous variable
  2. aSamples were excluded from the analysis process for the corresponding marker if the marker serum level of each sample exceeded three times the quartile range above the median