Genetic polymorphisms of autophagy-related gene 5 (ATG5) rs473543 predict different disease-free survivals of triple-negative breast cancer patients receiving anthracycline- and/or taxane-based adjuvant chemotherapy

Table 4 Univariate and multivariate analyses of prognostic factors for DFS of TNBC patients

Characteristic	Univariate analysis		Multivariate analysis
Characteristic	HR (95% CI)	P value	HR (95% CI)	P value
Age (≤ 40 vs. > 40 years)	1.038 (0.614–1.752)	0.890	–
T stage (pT0–T1 vs. pT2-T4)	1.393 (0.897–2.164)	0.140	–
Family history of breast cancer (yes vs. no)	0.771 (0.386–1.543)	0.463	–
Axillary lymph node status (negative vs. positive)	2.507 (1.615–3.890)	< 0.001	2.055 (1.190–3.547)	0.010
TNM stage (0-I vs. II-III)	2.063 (1.221–3.485)	0.007	1.237 (0.653–2.346)	0.514
Pathological type (invasive ductal carcinoma vs. others)	0.874 (0.450–1.695)	0.689	–
Vascular invasion (yes vs. no)	2.486 (1.497–4.126)	< 0.001	1.901 (1.124–3.216)	0.017
ATG5 rs473543 genotype (AA/GA vs. GG)	1.717 (1.036–2.847)	0.036	1.729 (1.041–2.870)	0.034

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