Genetic polymorphisms of autophagy-related gene 5 (ATG5) rs473543 predict different disease-free survivals of triple-negative breast cancer patients receiving anthracycline- and/or taxane-based adjuvant chemotherapy

Table 3 The relationship between ATG5 rs473543 genotypes and DFS in the recurrent group and the non-recurrent group of TNBC patients

Characteristic	Non-recurrent group (cases)		Recurrent group (cases)		P value
Characteristic	AA/GA	GG	AA/GA	GG	P value
Total	143	92	61	20
Age (years)
≤ 40	36	20	15	3	0.139
> 40	107	72	46	17	0.093
Family history of breast cancer
Yes	18	17	8	1	0.081
No	125	75	53	19	0.122
Axillary lymph node status
Negative	102	61	30	6	0.027
Positive	41	31	31	14	0.229
TNM stage
0–I	56	35	15	3	0.097
II–III	87	57	46	17	0.127
Invasive ductal carcinoma
Grade 1/2	47	28	25	9	0.410
Grade 3	82	49	25	8	0.179
Vascular invasion
Yes	16	10	15	5	0.444
No	127	82	46	15	0.068

DFS disease-free survival
In different subclinical groups, the relationship between ATG5 rs473543 genotypes and DFS was analyzed using Kaplan–Meier curves. Differences across survival curves were compared by the log-rank test, the P values for which were shown in this table

ISSN: 2523-3548