Table 1 Clinicopathological characteristics of patients with triple-negative breast cancer (TNBC) with respect to autophagy-related gene 5 (ATG5) rs473543 genotypes
Characteristic | Total [cases (%)] | ATG5 rs473543 genotype [cases (%)] | P | ||
|---|---|---|---|---|---|
AA | GG | GA | |||
Total | 316 | 60 | 112 | 144 | |
Age (years) | 0.233 | ||||
≤ 40 | 74 (23.4) | 11 (18.3) | 23 (20.5) | 40 (27.8) | |
> 40 | 242 (76.6) | 49 (81.7) | 89 (79.5) | 104 (72.2) | |
T stage | 0.231 | ||||
pT0–T1 | 156 (49.4) | 35 (58.3) | 50 (44.6) | 71 (49.3) | |
pT2–T4 | 160 (50.6) | 25 (41.7) | 62 (55.4) | 73 (50.7) | |
Axillary lymph node status | 0.543 | ||||
Negative | 199 (63.0) | 41 (68.3) | 67 (59.8) | 91 (63.2) | |
Positive | 117 (37.0) | 19 (31.7) | 45 (40.2) | 53 (36.8) | |
TNM stage | 0.948 | ||||
0–I | 109 (34.5) | 20 (33.3) | 38 (33.9) | 51 (35.4) | |
II–III | 207 (65.5) | 40 (66.7) | 74 (66.1) | 93 (64.6) | |
Pathological type | 0.855 | ||||
Invasive ductal carcinoma | 294 (93.0) | 58 (96.7) | 102 (91.1) | 134 (93.1) | |
Grade 1/2 | 109 (34.5) | 24 (40.0) | 37 (33.0) | 48 (33.3) | |
Grade 3 | 164 (51.9) | 30 (50.0) | 57 (50.9) | 77 (53.5) | |
Unknown | 21 (6.6) | 4 (6.7) | 8 (7.1) | 9 (6.3) | |
Others | 22 (7.0) | 2 (3.3) | 10 (8.9) | 10 (6.9) | |
Vascular invasion | 0.594 | ||||
Yes | 46 (14.6) | 7 (11.7) | 15 (13.4) | 24 (16.7) | |
No | 270 (85.4) | 53 (88.3) | 97 (86.6) | 120 (83.3) | |
Adjuvant radiotherapy | 0.396 | ||||
Yes | 121 (38.3) | 21 (35.0) | 39 (34.8) | 61 (42.4) | |
No | 195 (61.7) | 39 (65.0) | 73 (65.2) | 83 (57.6) | |
Chemotherapeutic regimensa | 0.455 | ||||
Anthracycline-based | 222 (70.3) | 43 (71.7) | 67 (59.8) | 112 (77.8) | |
Taxane-based | 251 (79.4) | 47 (78.3) | 95 (84.8) | 109 (75.7) | |
Anthracycline-taxane combination | 157 (70.7) | 30 (50.0) | 50 (44.6) | 77 (53.5) | |