Fig. 5
From: Systematic analyses of glutamine and glutamate metabolisms across different cancer types
The estimated level of statistical contribution: a to purine synthesis from glutamine (gln), adenosine (ade), guanosine (gua) and inosine (ino); b pyrimidine synthesis from glutamine, cytidine (cyt) and uridine (uri); c energy synthesis from glutamine and glucose (glc); d lipid synthesis from glutamine and glucose; e nucleotide synthesis from glutamine and glucose; f UDP-GlcNAc synthesis from glutamine and glucosamine (glnc); g asparagine synthesis from glutamine; h proline synthesis from glutamine and arginine (arg); i serine synthesis from glutamate (glu); j GSH synthesis from glutamate synthesis (glu_synt), and transport (glu_trsp). In each panel, ID is a variable for assessing whether the expression level of a response pathway in the linear model differs significantly in cancer and controls, whereas ID:X is the estimated contribution of factor X to the response pathway, where the color represents if a factor has increased (red) or decreased (green) contribution in cancer and controls. BLCA, bladder urothelial carcinoma; BRCA, breast invasive carcinoma; COAD, colon adenocarcinoma; HNSC, head and neck squamous cell carcinoma; KICH, kidney chromophobe; KIRC, kidney renal clear cell carcinoma; KIRP, kidney renal papillary cell carcinoma; LIHC, liver hepatocellular carcinoma; LUAD, lung adenocarcinoma; PRAD, prostate adenocarcinoma; THCA, thyroid carcinoma